AnyAD: Unified Any-Modality Anomaly Detection in Incomplete Multi-Sequence MRI

Reliable anomaly detection in brain MRI remains challenging due to the scarcity of annotated abnormal cases and the frequent absence of key imaging modalities in real clinical workflows. Existing single-class or multi-class anomaly detection (AD) models typically rely on fixed modality configurations, require repetitive training, or fail to generalize to unseen modality combinations, limiting their clinical scalability. In this work, we present a unified Any-Modality AD framework that performs robust anomaly detection and localization under arbitrary MRI modality availability. The framework integrates a dual-pathway DINOv2 encoder with a feature distribution alignment mechanism that statistically aligns incomplete-modality features with full-modality representations, enabling stable inference even with severe modality dropout. To further enhance semantic consistency, we introduce an Intrinsic Normal Prototypes (INPs) extractor and an INP-guided decoder that reconstruct only normal anatomical patterns while naturally amplifying abnormal deviations. Through randomized modality masking and indirect feature completion during training, the model learns to adapt to all modality configurations without re-training. Extensive experiments on BraTS2018, MU-Glioma-Post, and Pretreat-MetsToBrain-Masks demonstrate that our approach consistently surpasses state-of-the-art industrial and medical AD baselines across 7 modality combinations, achieving superior generalization. This study establishes a scalable paradigm for multimodal medical AD under real-world, imperfect modality conditions. Our source code is available at https://github.com/wuchangw/AnyAD.

Prototypical Learning Guided Context-Aware Segmentation Network for Few-Shot Anomaly Detection

Few-shot anomaly detection (FSAD) denotes the identification of anomalies within a target category with a limited number of normal samples. Existing FSAD methods largely rely on pre-trained feature representations to detect anomalies, but the inherent domain gap between pre-trained representations and target FSAD scenarios is often overlooked. This study proposes a Prototypical Learning Guided Context-Aware Segmentation Network (PCSNet) to address the domain gap, thereby improving feature descriptiveness in target scenarios and enhancing FSAD performance. In particular, PCSNet comprises a prototypical feature adaption (PFA) sub-network and a context-aware segmentation (CAS) sub-network. PFA extracts prototypical features as guidance to ensure better feature compactness for normal data while distinct separation from anomalies. A pixel-level disparity classification loss is also designed to make subtle anomalies more distinguishable. Then a CAS sub-network is introduced for pixel-level anomaly localization, where pseudo anomalies are exploited to facilitate the training process. Experimental results on MVTec and MPDD demonstrate the superior FSAD performance of PCSNet, with 94.9% and 80.2% image-level AUROC in an 8-shot scenario, respectively. Real-world applications on automotive plastic part inspection further demonstrate that PCSNet can achieve promising results with limited training samples. Code is available at https://github.com/yuxin-jiang/PCSNet.

Anomagic: Crossmodal Prompt-driven Zero-shot Anomaly Generation

We propose Anomagic, a zero-shot anomaly generation method that produces semantically coherent anomalies without requiring any exemplar anomalies. By unifying both visual and textual cues through a crossmodal prompt encoding scheme, Anomagic leverages rich contextual information to steer an inpainting-based generation pipeline. A subsequent contrastive refinement strategy enforces precise alignment between synthesized anomalies and their masks, thereby bolstering downstream anomaly detection accuracy. To facilitate training, we introduce AnomVerse, a collection of 12,987 anomaly-mask-caption triplets assembled from 13 publicly available datasets, where captions are automatically generated by multimodal large language models using structured visual prompts and template-based textual hints. Extensive experiments demonstrate that Anomagic trained on AnomVerse can synthesize more realistic and varied anomalies than prior methods, yielding superior improvements in downstream anomaly detection. Furthermore, Anomagic can generate anomalies for any normal-category image using user-defined prompts, establishing a versatile foundation model for anomaly generation.

Levarging Learning Bias for Noisy Anomaly Detection

This paper addresses the challenge of fully unsupervised image anomaly detection (FUIAD), where training data may contain unlabeled anomalies. Conventional methods assume anomaly-free training data, but real-world contamination leads models to absorb anomalies as normal, degrading detection performance. To mitigate this, we propose a two-stage framework that systematically exploits inherent learning bias in models. The learning bias stems from: (1) the statistical dominance of normal samples, driving models to prioritize learning stable normal patterns over sparse anomalies, and (2) feature-space divergence, where normal data exhibit high intra-class consistency while anomalies display high diversity, leading to unstable model responses. Leveraging the learning bias, stage 1 partitions the training set into subsets, trains sub-models, and aggregates cross-model anomaly scores to filter a purified dataset. Stage 2 trains the final detector on this dataset. Experiments on the Real-IAD benchmark demonstrate superior anomaly detection and localization performance under different noise conditions. Ablation studies further validate the framework's contamination resilience, emphasizing the critical role of learning bias exploitation. The model-agnostic design ensures compatibility with diverse unsupervised backbones, offering a practical solution for real-world scenarios with imperfect training data. Code is available at https://github.com/hustzhangyuxin/LLBNAD.

Mentor3AD: Feature Reconstruction-based 3D Anomaly Detection via Multi-modality Mentor Learning

Multimodal feature reconstruction is a promising approach for 3D anomaly detection, leveraging the complementary information from dual modalities. We further advance this paradigm by utilizing multi-modal mentor learning, which fuses intermediate features to further distinguish normal from feature differences. To address these challenges, we propose a novel method called Mentor3AD, which utilizes multi-modal mentor learning. By leveraging the shared features of different modalities, Mentor3AD can extract more effective features and guide feature reconstruction, ultimately improving detection performance. Specifically, Mentor3AD includes a Mentor of Fusion Module (MFM) that merges features extracted from RGB and 3D modalities to create a mentor feature. Additionally, we have designed a Mentor of Guidance Module (MGM) to facilitate cross-modal reconstruction, supported by the mentor feature. Lastly, we introduce a Voting Module (VM) to more accurately generate the final anomaly score. Extensive comparative and ablation studies on MVTec 3D-AD and Eyecandies have verified the effectiveness of the proposed method.

Visual Anomaly Detection under Complex View-Illumination Interplay: A Large-Scale Benchmark

The practical deployment of Visual Anomaly Detection (VAD) systems is hindered by their sensitivity to real-world imaging variations, particularly the complex interplay between viewpoint and illumination which drastically alters defect visibility. Current benchmarks largely overlook this critical challenge. We introduce Multi-View Multi-Illumination Anomaly Detection (M2AD), a new large-scale benchmark comprising 119,880 high-resolution images designed explicitly to probe VAD robustness under such interacting conditions. By systematically capturing 999 specimens across 10 categories using 12 synchronized views and 10 illumination settings (120 configurations total), M2AD enables rigorous evaluation. We establish two evaluation protocols: M2AD-Synergy tests the ability to fuse information across diverse configurations, and M2AD-Invariant measures single-image robustness against realistic view-illumination effects. Our extensive benchmarking shows that state-of-the-art VAD methods struggle significantly on M2AD, demonstrating the profound challenge posed by view-illumination interplay. This benchmark serves as an essential tool for developing and validating VAD methods capable of overcoming real-world complexities. Our full dataset and test suite will be released at https://hustcyq.github.io/M2AD to facilitate the field.

Boosting Global-Local Feature Matching via Anomaly Synthesis for Multi-Class Point Cloud Anomaly Detection

Point cloud anomaly detection is essential for various industrial applications. The huge computation and storage costs caused by the increasing product classes limit the application of single-class unsupervised methods, necessitating the development of multi-class unsupervised methods. However, the feature similarity between normal and anomalous points from different class data leads to the feature confusion problem, which greatly hinders the performance of multi-class methods. Therefore, we introduce a multi-class point cloud anomaly detection method, named GLFM, leveraging global-local feature matching to progressively separate data that are prone to confusion across multiple classes. Specifically, GLFM is structured into three stages: Stage-I proposes an anomaly synthesis pipeline that stretches point clouds to create abundant anomaly data that are utilized to adapt the point cloud feature extractor for better feature representation. Stage-II establishes the global and local memory banks according to the global and local feature distributions of all the training data, weakening the impact of feature confusion on the establishment of the memory bank. Stage-III implements anomaly detection of test data leveraging its feature distance from global and local memory banks. Extensive experiments on the MVTec 3D-AD, Real3D-AD and actual industry parts dataset showcase our proposed GLFM's superior point cloud anomaly detection performance. The code is available at https://github.com/hustCYQ/GLFM-Multi-class-3DAD.

Exploring Intrinsic Normal Prototypes within a Single Image for Universal Anomaly Detection

Anomaly detection (AD) is essential for industrial inspection, yet existing methods typically rely on ``comparing'' test images to normal references from a training set. However, variations in appearance and positioning often complicate the alignment of these references with the test image, limiting detection accuracy. We observe that most anomalies manifest as local variations, meaning that even within anomalous images, valuable normal information remains. We argue that this information is useful and may be more aligned with the anomalies since both the anomalies and the normal information originate from the same image. Therefore, rather than relying on external normality from the training set, we propose INP-Former, a novel method that extracts Intrinsic Normal Prototypes (INPs) directly from the test image. Specifically, we introduce the INP Extractor, which linearly combines normal tokens to represent INPs. We further propose an INP Coherence Loss to ensure INPs can faithfully represent normality for the testing image. These INPs then guide the INP-Guided Decoder to reconstruct only normal tokens, with reconstruction errors serving as anomaly scores. Additionally, we propose a Soft Mining Loss to prioritize hard-to-optimize samples during training. INP-Former achieves state-of-the-art performance in single-class, multi-class, and few-shot AD tasks across MVTec-AD, VisA, and Real-IAD, positioning it as a versatile and universal solution for AD. Remarkably, INP-Former also demonstrates some zero-shot AD capability. Code is available at:https://github.com/luow23/INP-Former.

VarAD: Lightweight High-Resolution Image Anomaly Detection via Visual Autoregressive Modeling

This paper addresses a practical task: High-Resolution Image Anomaly Detection (HRIAD). In comparison to conventional image anomaly detection for low-resolution images, HRIAD imposes a heavier computational burden and necessitates superior global information capture capacity. To tackle HRIAD, this paper translates image anomaly detection into visual token prediction and proposes VarAD based on visual autoregressive modeling for token prediction. Specifically, VarAD first extracts multi-hierarchy and multi-directional visual token sequences, and then employs an advanced model, Mamba, for visual autoregressive modeling and token prediction. During the prediction process, VarAD effectively exploits information from all preceding tokens to predict the target token. Finally, the discrepancies between predicted tokens and original tokens are utilized to score anomalies. Comprehensive experiments on four publicly available datasets and a real-world button inspection dataset demonstrate that the proposed VarAD achieves superior high-resolution image anomaly detection performance while maintaining lightweight, rendering VarAD a viable solution for HRIAD. Code is available at \href{https://github.com/caoyunkang/VarAD}{\url{https://github.com/caoyunkang/VarAD}}.

AdaCLIP: Adapting CLIP with Hybrid Learnable Prompts for Zero-Shot Anomaly Detection

Zero-shot anomaly detection (ZSAD) targets the identification of anomalies within images from arbitrary novel categories. This study introduces AdaCLIP for the ZSAD task, leveraging a pre-trained vision-language model (VLM), CLIP. AdaCLIP incorporates learnable prompts into CLIP and optimizes them through training on auxiliary annotated anomaly detection data. Two types of learnable prompts are proposed: static and dynamic. Static prompts are shared across all images, serving to preliminarily adapt CLIP for ZSAD. In contrast, dynamic prompts are generated for each test image, providing CLIP with dynamic adaptation capabilities. The combination of static and dynamic prompts is referred to as hybrid prompts, and yields enhanced ZSAD performance. Extensive experiments conducted across 14 real-world anomaly detection datasets from industrial and medical domains indicate that AdaCLIP outperforms other ZSAD methods and can generalize better to different categories and even domains. Finally, our analysis highlights the importance of diverse auxiliary data and optimized prompts for enhanced generalization capacity. Code is available at https://github.com/caoyunkang/AdaCLIP.