Dynamic PET Image Prediction Using a Network Combining Reversible and Irreversible Modules

Dynamic positron emission tomography (PET) images can reveal the distribution of tracers in the organism and the dynamic processes involved in biochemical reactions, and it is widely used in clinical practice. Despite the high effectiveness of dynamic PET imaging in studying the kinetics and metabolic processes of radiotracers. Pro-longed scan times can cause discomfort for both patients and medical personnel. This study proposes a dynamic frame prediction method for dynamic PET imaging, reduc-ing dynamic PET scanning time by applying a multi-module deep learning framework composed of reversible and irreversible modules. The network can predict kinetic parameter images based on the early frames of dynamic PET images, and then generate complete dynamic PET images. In validation experiments with simulated data, our network demonstrated good predictive performance for kinetic parameters and was able to reconstruct high-quality dynamic PET images. Additionally, in clinical data experiments, the network exhibited good generalization performance and attached that the proposed method has promising clinical application prospects.

CC-DCNet: Dynamic Convolutional Neural Network with Contrastive Constraints for Identifying Lung Cancer Subtypes on Multi-modality Images

The accurate diagnosis of pathological subtypes of lung cancer is of paramount importance for follow-up treatments and prognosis managements. Assessment methods utilizing deep learning technologies have introduced novel approaches for clinical diagnosis. However, the majority of existing models rely solely on single-modality image input, leading to limited diagnostic accuracy. To this end, we propose a novel deep learning network designed to accurately classify lung cancer subtype with multi-dimensional and multi-modality images, i.e., CT and pathological images. The strength of the proposed model lies in its ability to dynamically process both paired CT-pathological image sets as well as independent CT image sets, and consequently optimize the pathology-related feature extractions from CT images. This adaptive learning approach enhances the flexibility in processing multi-dimensional and multi-modality datasets and results in performance elevating in the model testing phase. We also develop a contrastive constraint module, which quantitatively maps the cross-modality associations through network training, and thereby helps to explore the "gold standard" pathological information from the corresponding CT scans. To evaluate the effectiveness, adaptability, and generalization ability of our model, we conducted extensive experiments on a large-scale multi-center dataset and compared our model with a series of state-of-the-art classification models. The experimental results demonstrated the superiority of our model for lung cancer subtype classification, showcasing significant improvements in accuracy metrics such as ACC, AUC, and F1-score.

SES: Bridging the Gap Between Explainability and Prediction of Graph Neural Networks

Despite the Graph Neural Networks' (GNNs) proficiency in analyzing graph data, achieving high-accuracy and interpretable predictions remains challenging. Existing GNN interpreters typically provide post-hoc explanations disjointed from GNNs' predictions, resulting in misrepresentations. Self-explainable GNNs offer built-in explanations during the training process. However, they cannot exploit the explanatory outcomes to augment prediction performance, and they fail to provide high-quality explanations of node features and require additional processes to generate explainable subgraphs, which is costly. To address the aforementioned limitations, we propose a self-explained and self-supervised graph neural network (SES) to bridge the gap between explainability and prediction. SES comprises two processes: explainable training and enhanced predictive learning. During explainable training, SES employs a global mask generator co-trained with a graph encoder and directly produces crucial structure and feature masks, reducing time consumption and providing node feature and subgraph explanations. In the enhanced predictive learning phase, mask-based positive-negative pairs are constructed utilizing the explanations to compute a triplet loss and enhance the node representations by contrastive learning.

Graph Structure Prompt Learning: A Novel Methodology to Improve Performance of Graph Neural Networks

Graph neural networks (GNNs) are widely applied in graph data modeling. However, existing GNNs are often trained in a task-driven manner that fails to fully capture the intrinsic nature of the graph structure, resulting in sub-optimal node and graph representations. To address this limitation, we propose a novel Graph structure Prompt Learning method (GPL) to enhance the training of GNNs, which is inspired by prompt mechanisms in natural language processing. GPL employs task-independent graph structure losses to encourage GNNs to learn intrinsic graph characteristics while simultaneously solving downstream tasks, producing higher-quality node and graph representations. In extensive experiments on eleven real-world datasets, after being trained by GPL, GNNs significantly outperform their original performance on node classification, graph classification, and edge prediction tasks (up to 10.28%, 16.5%, and 24.15%, respectively). By allowing GNNs to capture the inherent structural prompts of graphs in GPL, they can alleviate the issue of over-smooth and achieve new state-of-the-art performances, which introduces a novel and effective direction for GNN research with potential applications in various domains.

Aligning Human Motion Generation with Human Perceptions

Human motion generation is a critical task with a wide range of applications. Achieving high realism in generated motions requires naturalness, smoothness, and plausibility. Despite rapid advancements in the field, current generation methods often fall short of these goals. Furthermore, existing evaluation metrics typically rely on ground-truth-based errors, simple heuristics, or distribution distances, which do not align well with human perceptions of motion quality. In this work, we propose a data-driven approach to bridge this gap by introducing a large-scale human perceptual evaluation dataset, MotionPercept, and a human motion critic model, MotionCritic, that capture human perceptual preferences. Our critic model offers a more accurate metric for assessing motion quality and could be readily integrated into the motion generation pipeline to enhance generation quality. Extensive experiments demonstrate the effectiveness of our approach in both evaluating and improving the quality of generated human motions by aligning with human perceptions. Code and data are publicly available at https://motioncritic.github.io/.

Space-time Reinforcement Network for Video Object Segmentation

Recently, video object segmentation (VOS) networks typically use memory-based methods: for each query frame, the mask is predicted by space-time matching to memory frames. Despite these methods having superior performance, they suffer from two issues: 1) Challenging data can destroy the space-time coherence between adjacent video frames. 2) Pixel-level matching will lead to undesired mismatching caused by the noises or distractors. To address the aforementioned issues, we first propose to generate an auxiliary frame between adjacent frames, serving as an implicit short-temporal reference for the query one. Next, we learn a prototype for each video object and prototype-level matching can be implemented between the query and memory. The experiment demonstrated that our network outperforms the state-of-the-art method on the DAVIS 2017, achieving a J&F score of 86.4%, and attains a competitive result 85.0% on YouTube VOS 2018. In addition, our network exhibits a high inference speed of 32+ FPS.

Efficient Action Counting with Dynamic Queries

Temporal repetition counting aims to quantify the repeated action cycles within a video. The majority of existing methods rely on the similarity correlation matrix to characterize the repetitiveness of actions, but their scalability is hindered due to the quadratic computational complexity. In this work, we introduce a novel approach that employs an action query representation to localize repeated action cycles with linear computational complexity. Based on this representation, we further develop two key components to tackle the essential challenges of temporal repetition counting. Firstly, to facilitate open-set action counting, we propose the dynamic update scheme on action queries. Unlike static action queries, this approach dynamically embeds video features into action queries, offering a more flexible and generalizable representation. Secondly, to distinguish between actions of interest and background noise actions, we incorporate inter-query contrastive learning to regularize the video representations corresponding to different action queries. As a result, our method significantly outperforms previous works, particularly in terms of long video sequences, unseen actions, and actions at various speeds. On the challenging RepCountA benchmark, we outperform the state-of-the-art method TransRAC by 26.5% in OBO accuracy, with a 22.7% mean error decrease and 94.1% computational burden reduction. Code is available at https://github.com/lizishi/DeTRC.

OpenMEDLab: An Open-source Platform for Multi-modality Foundation Models in Medicine

The emerging trend of advancing generalist artificial intelligence, such as GPTv4 and Gemini, has reshaped the landscape of research (academia and industry) in machine learning and many other research areas. However, domain-specific applications of such foundation models (e.g., in medicine) remain untouched or often at their very early stages. It will require an individual set of transfer learning and model adaptation techniques by further expanding and injecting these models with domain knowledge and data. The development of such technologies could be largely accelerated if the bundle of data, algorithms, and pre-trained foundation models were gathered together and open-sourced in an organized manner. In this work, we present OpenMEDLab, an open-source platform for multi-modality foundation models. It encapsulates not only solutions of pioneering attempts in prompting and fine-tuning large language and vision models for frontline clinical and bioinformatic applications but also building domain-specific foundation models with large-scale multi-modal medical data. Importantly, it opens access to a group of pre-trained foundation models for various medical image modalities, clinical text, protein engineering, etc. Inspiring and competitive results are also demonstrated for each collected approach and model in a variety of benchmarks for downstream tasks. We welcome researchers in the field of medical artificial intelligence to continuously contribute cutting-edge methods and models to OpenMEDLab, which can be accessed via https://github.com/openmedlab.

Language Models Represent Beliefs of Self and Others

Understanding and attributing mental states, known as Theory of Mind (ToM), emerges as a fundamental capability for human social reasoning. While Large Language Models (LLMs) appear to possess certain ToM abilities, the mechanisms underlying these capabilities remain elusive. In this study, we discover that it is possible to linearly decode the belief status from the perspectives of various agents through neural activations of language models, indicating the existence of internal representations of self and others' beliefs. By manipulating these representations, we observe dramatic changes in the models' ToM performance, underscoring their pivotal role in the social reasoning process. Additionally, our findings extend to diverse social reasoning tasks that involve different causal inference patterns, suggesting the potential generalizability of these representations.

Real-time Holistic Robot Pose Estimation with Unknown States

Estimating robot pose from RGB images is a crucial problem in computer vision and robotics. While previous methods have achieved promising performance, most of them presume full knowledge of robot internal states, e.g. ground-truth robot joint angles, which are not always available in real-world scenarios. On the other hand, existing approaches that estimate robot pose without joint state priors suffer from heavy computation burdens and thus cannot support real-time applications. This work addresses the urgent need for efficient robot pose estimation with unknown states. We propose an end-to-end pipeline for real-time, holistic robot pose estimation from a single RGB image, even in the absence of known robot states. Our method decomposes the problem into estimating camera-to-robot rotation, robot state parameters, keypoint locations, and root depth. We further design a corresponding neural network module for each task. This approach allows for learning multi-facet representations and facilitates sim-to-real transfer through self-supervised learning. Notably, our method achieves inference with a single feedforward, eliminating the need for costly test-time iterative optimization. As a result, it delivers a 12-time speed boost with state-of-the-art accuracy, enabling real-time holistic robot pose estimation for the first time. Code is available at https://oliverbansk.github.io/Holistic-Robot-Pose/.