Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, Peng Cheng Laboratory, Shenzhen, China
Abstract:High-Level Synthesis (HLS) design space exploration (DSE) seeks Pareto-optimal designs within expansive pragma configuration spaces. To accelerate HLS DSE, graph neural networks (GNNs) are commonly employed as surrogates for HLS tools to predict quality of results (QoR) metrics, while multi-objective optimization algorithms expedite the exploration. However, GNN-based prediction methods may not fully capture the rich semantic features inherent in behavioral descriptions, and conventional multi-objective optimization algorithms often do not explicitly account for the domain-specific knowledge regarding how pragma directives influence QoR. To address these limitations, this paper proposes the MPM-LLM4DSE framework, which incorporates a multimodal prediction model (MPM) that simultaneously fuses features from behavioral descriptions and control and data flow graphs. Furthermore, the framework employs a large language model (LLM) as an optimizer, accompanied by a tailored prompt engineering methodology. This methodology incorporates pragma impact analysis on QoR to guide the LLM in generating high-quality configurations (LLM4DSE). Experimental results demonstrate that our multimodal predictive model significantly outperforms state-of-the-art work ProgSG by up to 10.25$\times$. Furthermore, in DSE tasks, the proposed LLM4DSE achieves an average performance gain of 39.90\% over prior methods, validating the effectiveness of our prompting methodology. Code and models are available at https://github.com/wslcccc/MPM-LLM4DSE.
Abstract:Single Domain Generalization (SDG) for object detection aims to train a model on a single source domain that can generalize effectively to unseen target domains. While recent methods like CLIP-based semantic augmentation have shown promise, they often overlook the underlying structure of feature distributions and frequency-domain characteristics that are critical for robustness. In this paper, we propose a novel framework that enhances SDG object detection by integrating the von Mises-Fisher (vMF) distribution and Fourier transformation into a CLIP-guided pipeline. Specifically, we model the directional features of object representations using vMF to better capture domain-invariant semantic structures in the embedding space. Additionally, we introduce a Fourier-based augmentation strategy that perturbs amplitude and phase components to simulate domain shifts in the frequency domain, further improving feature robustness. Our method not only preserves the semantic alignment benefits of CLIP but also enriches feature diversity and structural consistency across domains. Extensive experiments on the diverse weather-driving benchmark demonstrate that our approach outperforms the existing state-of-the-art method.
Abstract:Expectile regression neural networks (ERNNs) are powerful tools for capturing heterogeneity and complex nonlinear structures in data. However, most existing research has primarily focused on fully observed data, with limited attention paid to scenarios involving censored observations. In this paper, we propose a data augmentation based ERNNs algorithm, termed DAERNN, for modeling heterogeneous censored data. The proposed DAERNN is fully data driven, requires minimal assumptions, and offers substantial flexibility. Simulation studies and real data applications demonstrate that DAERNN outperforms existing censored ERNNs methods and achieves predictive performance comparable to models trained on fully observed data. Moreover, the algorithm provides a unified framework for handling various censoring mechanisms without requiring explicit parametric model specification, thereby enhancing its applicability to practical censored data analysis.
Abstract:Extensive experiments and prior studies show that no single maximum clique algorithm consistently performs best across all instances, highlighting the importance of selecting suitable algorithms based on instance features. Through an extensive analysis of relevant studies, it is found that there is a lack of research work concerning algorithm selection oriented toward the Maximum Clique Problem (MCP). In this work, we propose a learning-based framework that integrates both traditional machine learning and graph neural networks to address this gap. We construct a labeled dataset by running four exact MCP algorithms on a diverse collection of graph instances, accompanied by structural and global statistical features extracted from each graph. We first evaluate four conventional classifiers: Support Vector Machine (SVM), Random Forest (RF), Decision Tree (DT), and K-Nearest Neighbors (KNN), across multiple dataset variants. Experimental results show that RF consistently shows strong performance across metrics and dataset variants, making it a reliable baseline. In addition, feature importance analysis indicates that connectivity and topological structure are strong predictors of algorithm performance. Building on these findings, we develop a dual-channel model named GAT-MLP, which combines a Graph Attention Network (GAT) for local structural encoding with a Multilayer Perceptron (MLP) for global feature modeling. The GAT-MLP model shows strong and consistent performance across all metrics. Our results highlight the effectiveness of dual-channel architectures and the promise of graph neural networks in combinatorial algorithm selection.
Abstract:In medical imaging, 4D MRI enables dynamic 3D visualization, yet the trade-off between spatial and temporal resolution requires prolonged scan time that can compromise temporal fidelity--especially during rapid, large-amplitude motion. Traditional approaches typically rely on registration-based interpolation to generate intermediate frames. However, these methods struggle with large deformations, resulting in misregistration, artifacts, and diminished spatial consistency. To address these challenges, we propose TSSC-Net, a novel framework that generates intermediate frames while preserving spatial consistency. To improve temporal fidelity under fast motion, our diffusion-based temporal super-resolution network generates intermediate frames using the start and end frames as key references, achieving 6x temporal super-resolution in a single inference step. Additionally, we introduce a novel tri-directional Mamba-based module that leverages long-range contextual information to effectively resolve spatial inconsistencies arising from cross-slice misalignment, thereby enhancing volumetric coherence and correcting cross-slice errors. Extensive experiments were performed on the public ACDC cardiac MRI dataset and a real-world dynamic 4D knee joint dataset. The results demonstrate that TSSC-Net can generate high-resolution dynamic MRI from fast-motion data while preserving structural fidelity and spatial consistency.
Abstract:Accurately delineating the visual pathway (VP) is crucial for understanding the human visual system and diagnosing related disorders. Exploring multi-parametric MR imaging data has been identified as an important way to delineate VP. However, due to the complex cross-sequence relationships, existing methods cannot effectively model the complementary information from different MRI sequences. In addition, these existing methods heavily rely on large training data with labels, which is labor-intensive and time-consuming to obtain. In this work, we propose a novel semi-supervised multi-parametric feature decomposition framework for VP delineation. Specifically, a correlation-constrained feature decomposition (CFD) is designed to handle the complex cross-sequence relationships by capturing the unique characteristics of each MRI sequence and easing the multi-parametric information fusion process. Furthermore, a consistency-based sample enhancement (CSE) module is developed to address the limited labeled data issue, by generating and promoting meaningful edge information from unlabeled data. We validate our framework using two public datasets, and one in-house Multi-Shell Diffusion MRI (MDM) dataset. Experimental results demonstrate the superiority of our approach in terms of delineation performance when compared to seven state-of-the-art approaches.
Abstract:Semi-supervised learning (SSL) has achieved significant progress in medical image segmentation (SSMIS) through effective utilization of limited labeled data. While current SSL methods for medical images predominantly rely on consistency regularization and pseudo-labeling, they often overlook transferable semantic relationships across different clinical domains and imaging modalities. To address this, we propose TransMedSeg, a novel transferable semantic framework for semi-supervised medical image segmentation. Our approach introduces a Transferable Semantic Augmentation (TSA) module, which implicitly enhances feature representations by aligning domain-invariant semantics through cross-domain distribution matching and intra-domain structural preservation. Specifically, TransMedSeg constructs a unified feature space where teacher network features are adaptively augmented towards student network semantics via a lightweight memory module, enabling implicit semantic transformation without explicit data generation. Interestingly, this augmentation is implicitly realized through an expected transferable cross-entropy loss computed over the augmented teacher distribution. An upper bound of the expected loss is theoretically derived and minimized during training, incurring negligible computational overhead. Extensive experiments on medical image datasets demonstrate that TransMedSeg outperforms existing semi-supervised methods, establishing a new direction for transferable representation learning in medical image analysis.
Abstract:Scaling up model and data size have demonstrated impressive performance improvement over a wide range of tasks. Despite extensive studies on scaling behaviors for general-purpose tasks, medical images exhibit substantial differences from natural data. It remains unclear the key factors in developing medical vision foundation models at scale due to the absence of an extensive understanding of scaling behavior in the medical domain. In this paper, we explored the scaling behavior across model sizes, training algorithms, data sizes, and imaging modalities in developing scalable medical vision foundation models by self-supervised learning. To support scalable pretraining, we introduce BioVFM-21M, a large-scale biomedical image dataset encompassing a wide range of biomedical image modalities and anatomies. We observed that scaling up does provide benefits but varies across tasks. Additional analysis reveals several factors correlated with scaling benefits. Finally, we propose BioVFM, a large-scale medical vision foundation model pretrained on 21 million biomedical images, which outperforms the previous state-of-the-art foundation models across 12 medical benchmarks. Our results highlight that while scaling up is beneficial for pursuing better performance, task characteristics, data diversity, pretraining methods, and computational efficiency remain critical considerations for developing scalable medical foundation models.
Abstract:High-level synthesis (HLS) design space exploration (DSE) is an optimization process in electronic design automation (EDA) that systematically explores high-level design configurations to achieve Pareto-optimal hardware implementations balancing performance, area, and power (PPA). To optimize this process, HLS prediction tasks often employ message-passing neural networks (MPNNs), leveraging complex architectures to achieve high accuracy. These predictors serve as evaluators in the DSE process, effectively bypassing the time-consuming estimations traditionally required by HLS tools. However, existing models often prioritize structural complexity and minimization of training loss, overlooking task-specific characteristics. Additionally, while evolutionary algorithms are widely used in DSE, they typically require extensive domain-specific knowledge to design effective crossover and mutation operators. To address these limitations, we propose CoGNNs-LLMEA, a framework that integrates a graph neural network with task-adaptive message passing and a large language model-enhanced evolutionary algorithm. As a predictive model, CoGNNs directly leverages intermediate representations generated from source code after compiler front-end processing, enabling prediction of quality of results (QoR) without invoking HLS tools. Due to its strong adaptability to tasks, CoGNNs can be tuned to predict post-HLS and post-implementation outcomes, effectively bridging the gap between high-level abstractions and physical implementation characteristics. CoGNNs achieves state-of-the-art prediction accuracy in post-HLS QoR prediction, reducing mean prediction errors by 2.8$\times$ for latency and 3.4$\times$ for resource utilization compared to baseline models.
Abstract:The success of deep learning in intelligent ship visual perception relies heavily on rich image data. However, dedicated datasets for inland waterway vessels remain scarce, limiting the adaptability of visual perception systems in complex environments. Inland waterways, characterized by narrow channels, variable weather, and urban interference, pose significant challenges to object detection systems based on existing datasets. To address these issues, this paper introduces the Multi-environment Inland Waterway Vessel Dataset (MEIWVD), comprising 32,478 high-quality images from diverse scenarios, including sunny, rainy, foggy, and artificial lighting conditions. MEIWVD covers common vessel types in the Yangtze River Basin, emphasizing diversity, sample independence, environmental complexity, and multi-scale characteristics, making it a robust benchmark for vessel detection. Leveraging MEIWVD, this paper proposes a scene-guided image enhancement module to improve water surface images based on environmental conditions adaptively. Additionally, a parameter-limited dilated convolution enhances the representation of vessel features, while a multi-scale dilated residual fusion method integrates multi-scale features for better detection. Experiments show that MEIWVD provides a more rigorous benchmark for object detection algorithms, and the proposed methods significantly improve detector performance, especially in complex multi-environment scenarios.