Learned Image Compression for HE-stained Histopathological Images via Stain Deconvolution

Processing histopathological Whole Slide Images (WSI) leads to massive storage requirements for clinics worldwide. Even after lossy image compression during image acquisition, additional lossy compression is frequently possible without substantially affecting the performance of deep learning-based (DL) downstream tasks. In this paper, we show that the commonly used JPEG algorithm is not best suited for further compression and we propose Stain Quantized Latent Compression (SQLC ), a novel DL based histopathology data compression approach. SQLC compresses staining and RGB channels before passing it through a compression autoencoder (CAE ) in order to obtain quantized latent representations for maximizing the compression. We show that our approach yields superior performance in a classification downstream task, compared to traditional approaches like JPEG, while image quality metrics like the Multi-Scale Structural Similarity Index (MS-SSIM) is largely preserved. Our method is online available.

cOOpD: Reformulating COPD classification on chest CT scans as anomaly detection using contrastive representations

Classification of heterogeneous diseases is challenging due to their complexity, variability of symptoms and imaging findings. Chronic Obstructive Pulmonary Disease (COPD) is a prime example, being underdiagnosed despite being the third leading cause of death. Its sparse, diffuse and heterogeneous appearance on computed tomography challenges supervised binary classification. We reformulate COPD binary classification as an anomaly detection task, proposing cOOpD: heterogeneous pathological regions are detected as Out-of-Distribution (OOD) from normal homogeneous lung regions. To this end, we learn representations of unlabeled lung regions employing a self-supervised contrastive pretext model, potentially capturing specific characteristics of diseased and healthy unlabeled regions. A generative model then learns the distribution of healthy representations and identifies abnormalities (stemming from COPD) as deviations. Patient-level scores are obtained by aggregating region OOD scores. We show that cOOpD achieves the best performance on two public datasets, with an increase of 8.2% and 7.7% in terms of AUROC compared to the previous supervised state-of-the-art. Additionally, cOOpD yields well-interpretable spatial anomaly maps and patient-level scores which we show to be of additional value in identifying individuals in the early stage of progression. Experiments in artificially designed real-world prevalence settings further support that anomaly detection is a powerful way of tackling COPD classification.

Precise Energy Consumption Measurements of Heterogeneous Artificial Intelligence Workloads

With the rise of AI in recent years and the increase in complexity of the models, the growing demand in computational resources is starting to pose a significant challenge. The need for higher compute power is being met with increasingly more potent accelerators and the use of large compute clusters. However, the gain in prediction accuracy from large models trained on distributed and accelerated systems comes at the price of a substantial increase in energy demand, and researchers have started questioning the environmental friendliness of such AI methods at scale. Consequently, energy efficiency plays an important role for AI model developers and infrastructure operators alike. The energy consumption of AI workloads depends on the model implementation and the utilized hardware. Therefore, accurate measurements of the power draw of AI workflows on different types of compute nodes is key to algorithmic improvements and the design of future compute clusters and hardware. To this end, we present measurements of the energy consumption of two typical applications of deep learning models on different types of compute nodes. Our results indicate that 1. deriving energy consumption directly from runtime is not accurate, but the consumption of the compute node needs to be considered regarding its composition; 2. neglecting accelerator hardware on mixed nodes results in overproportional inefficiency regarding energy consumption; 3. energy consumption of model training and inference should be considered separately - while training on GPUs outperforms all other node types regarding both runtime and energy consumption, inference on CPU nodes can be comparably efficient. One advantage of our approach is that the information on energy consumption is available to all users of the supercomputer, enabling an easy transfer to other workloads alongside a raise in user-awareness of energy consumption.