A/B testing under Interference with Partial Network Information

A/B tests are often required to be conducted on subjects that might have social connections. For e.g., experiments on social media, or medical and social interventions to control the spread of an epidemic. In such settings, the SUTVA assumption for randomized-controlled trials is violated due to network interference, or spill-over effects, as treatments to group A can potentially also affect the control group B. When the underlying social network is known exactly, prior works have demonstrated how to conduct A/B tests adequately to estimate the global average treatment effect (GATE). However, in practice, it is often impossible to obtain knowledge about the exact underlying network. In this paper, we present UNITE: a novel estimator that relax this assumption and can identify GATE while only relying on knowledge of the superset of neighbors for any subject in the graph. Through theoretical analysis and extensive experiments, we show that the proposed approach performs better in comparison to standard estimators.

Zero-shot Microclimate Prediction with Deep Learning

Weather station data is a valuable resource for climate prediction, however, its reliability can be limited in remote locations. To compound the issue, making local predictions often relies on sensor data that may not be accessible for a new, previously unmonitored location. In response to these challenges, we propose a novel zero-shot learning approach designed to forecast various climate measurements at new and unmonitored locations. Our method surpasses conventional weather forecasting techniques in predicting microclimate variables by leveraging knowledge extracted from other geographic locations.

Machine Learning for Automated Mitral Regurgitation Detection from Cardiac Imaging

Mitral regurgitation (MR) is a heart valve disease with potentially fatal consequences that can only be forestalled through timely diagnosis and treatment. Traditional diagnosis methods are expensive, labor-intensive and require clinical expertise, posing a barrier to screening for MR. To overcome this impediment, we propose a new semi-supervised model for MR classification called CUSSP. CUSSP operates on cardiac imaging slices of the 4-chamber view of the heart. It uses standard computer vision techniques and contrastive models to learn from large amounts of unlabeled data, in conjunction with specialized classifiers to establish the first ever automated MR classification system. Evaluated on a test set of 179 labeled -- 154 non-MR and 25 MR -- sequences, CUSSP attains an F1 score of 0.69 and a ROC-AUC score of 0.88, setting the first benchmark result for this new task.

MultiWave: Multiresolution Deep Architectures through Wavelet Decomposition for Multivariate Time Series Prediction

The analysis of multivariate time series data is challenging due to the various frequencies of signal changes that can occur over both short and long terms. Furthermore, standard deep learning models are often unsuitable for such datasets, as signals are typically sampled at different rates. To address these issues, we introduce MultiWave, a novel framework that enhances deep learning time series models by incorporating components that operate at the intrinsic frequencies of signals. MultiWave uses wavelets to decompose each signal into subsignals of varying frequencies and groups them into frequency bands. Each frequency band is handled by a different component of our model. A gating mechanism combines the output of the components to produce sparse models that use only specific signals at specific frequencies. Our experiments demonstrate that MultiWave accurately identifies informative frequency bands and improves the performance of various deep learning models, including LSTM, Transformer, and CNN-based models, for a wide range of applications. It attains top performance in stress and affect detection from wearables. It also increases the AUC of the best-performing model by 5% for in-hospital COVID-19 mortality prediction from patient blood samples and for human activity recognition from accelerometer and gyroscope data. We show that MultiWave consistently identifies critical features and their frequency components, thus providing valuable insights into the applications studied.

Structure Mapping for Transferability of Causal Models

Human beings learn causal models and constantly use them to transfer knowledge between similar environments. We use this intuition to design a transfer-learning framework using object-oriented representations to learn the causal relationships between objects. A learned causal dynamics model can be used to transfer between variants of an environment with exchangeable perceptual features among objects but with the same underlying causal dynamics. We adapt continuous optimization for structure learning techniques to explicitly learn the cause and effects of the actions in an interactive environment and transfer to the target domain by categorization of the objects based on causal knowledge. We demonstrate the advantages of our approach in a gridworld setting by combining causal model-based approach with model-free approach in reinforcement learning.

Personalized Student Stress Prediction with Deep Multitask Network

With the growing popularity of wearable devices, the ability to utilize physiological data collected from these devices to predict the wearer's mental state such as mood and stress suggests great clinical applications, yet such a task is extremely challenging. In this paper, we present a general platform for personalized predictive modeling of behavioural states like students' level of stress. Through the use of Auto-encoders and Multitask learning we extend the prediction of stress to both sequences of passive sensor data and high-level covariates. Our model outperforms the state-of-the-art in the prediction of stress level from mobile sensor data, obtaining a 45.6 % improvement in F1 score on the StudentLife dataset.

Alzheimer's Disease Brain MRI Classification: Challenges and Insights

In recent years, many papers have reported state-of-the-art performance on Alzheimer's Disease classification with MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset using convolutional neural networks. However, we discover that when we split that data into training and testing sets at the subject level, we are not able to obtain similar performance, bringing the validity of many of the previous studies into question. Furthermore, we point out that previous works use different subsets of the ADNI data, making comparison across similar works tricky. In this study, we present the results of three splitting methods, discuss the motivations behind their validity, and report our results using all of the available subjects.

Multi-resolution Networks For Flexible Irregular Time Series Modeling (Multi-FIT)

Missing values, irregularly collected samples, and multi-resolution signals commonly occur in multivariate time series data, making predictive tasks difficult. These challenges are especially prevalent in the healthcare domain, where patients' vital signs and electronic records are collected at different frequencies and have occasionally missing information due to the imperfections in equipment or patient circumstances. Researchers have handled each of these issues differently, often handling missing data through mean value imputation and then using sequence models over the multivariate signals while ignoring the different resolution of signals. We propose a unified model named Multi-resolution Flexible Irregular Time series Network (Multi-FIT). The building block for Multi-FIT is the FIT network. The FIT network creates an informative dense representation at each time step using signal information such as last observed value, time difference since the last observed time stamp and overall mean for the signal. Vertical FIT (FIT-V) is a variant of FIT which also models the relationship between different temporal signals while creating the informative dense representations for the signal. The multi-FIT model uses multiple FIT networks for sets of signals with different resolutions, further facilitating the construction of flexible representations. Our model has three main contributions: a.) it does not impute values but rather creates informative representations to provide flexibility to the model for creating task-specific representations b.) it models the relationship between different signals in the form of support signals c.) it models different resolutions in parallel before merging them for the final prediction task. The FIT, FIT-V and Multi-FIT networks improve upon the state-of-the-art models for three predictive tasks, including the forecasting of patient survival.

FLARe: Forecasting by Learning Anticipated Representations

Computational models that forecast the progression of Alzheimer's disease at the patient level are extremely useful tools for identifying high risk cohorts for early intervention and treatment planning. The state-of-the-art work in this area proposes models that forecast by using latent representations extracted from the longitudinal data across multiple modalities, including volumetric information extracted from medical scans and demographic info. These models incorporate the time horizon, which is the amount of time between the last recorded visit and the future visit, by directly concatenating a representation of it to the data latent representation. In this paper, we present a model which generates a sequence of latent representations of the patient status across the time horizon, providing more informative modeling of the temporal relationships between the patient's history and future visits. Our proposed model outperforms the baseline in terms of forecasting accuracy and F1 score with the added benefit of robustly handling missing visits.

A Comprehensive Study of Alzheimer's Disease Classification Using Convolutional Neural Networks

A plethora of deep learning models have been developed for the task of Alzheimer's disease classification from brain MRI scans. Many of these models report high performance, achieving three-class classification accuracy of up to 95%. However, it is common for these studies to draw performance comparisons between models that are trained on different subsets of a dataset or use varying imaging preprocessing techniques, making it difficult to objectively assess model performance. Furthermore, many of these works do not provide details such as hyperparameters, the specific MRI scans used, or their source code, making it difficult to replicate their experiments. To address these concerns, we present a comprehensive study of some of the deep learning methods and architectures on the full set of images available from ADNI. We find that, (1) classification using 3D models gives an improvement of 1% in our setup, at the cost of significantly longer training time and more computation power, (2) with our dataset, pre-training yields minimal ($<0.5\%$) improvement in model performance, (3) most popular convolutional neural network models yield similar performance when compared to each other. Lastly, we briefly compare the effects of two image preprocessing programs: FreeSurfer and Clinica, and find that the spatially normalized and segmented outputs from Clinica increased the accuracy of model prediction from 63% to 89% when compared to FreeSurfer images.