Generative models for wearables data

Data scarcity is a common obstacle in medical research due to the high costs associated with data collection and the complexity of gaining access to and utilizing data. Synthesizing health data may provide an efficient and cost-effective solution to this shortage, enabling researchers to explore distributions and populations that are not represented in existing observations or difficult to access due to privacy considerations. To that end, we have developed a multi-task self-attention model that produces realistic wearable activity data. We examine the characteristics of the generated data and quantify its similarity to genuine samples with both quantitative and qualitative approaches.

Self-supervision of wearable sensors time-series data for influenza detection

Self-supervision may boost model performance in downstream tasks. However, there is no principled way of selecting the self-supervised objectives that yield the most adaptable models. Here, we study this problem on daily time-series data generated from wearable sensors used to detect onset of influenza-like illness (ILI). We first show that using self-supervised learning to predict next-day time-series values allows us to learn rich representations which can be adapted to perform accurate ILI prediction. Second, we perform an empirical analysis of three different self-supervised objectives to assess their adaptability to ILI prediction. Our results show that predicting the next day's resting heart rate or time-in-bed during sleep provides better representations for ILI prediction. These findings add to previous work demonstrating the practical application of self-supervised learning from activity data to improve health predictions.

Towards Industrial Private AI: A two-tier framework for data and model security

With the advances in 5G and IoT devices, the industries are vastly adopting artificial intelligence (AI) techniques for improving classification and prediction-based services. However, the use of AI also raises concerns regarding data privacy and security that can be misused or leaked. Private AI was recently coined to address the data security issue by combining AI with encryption techniques but existing studies have shown that model inversion attacks can be used to reverse engineer the images from model parameters. In this regard, we propose a federated learning and encryption-based private (FLEP) AI framework that provides two-tier security for data and model parameters in an IIoT environment. We proposed a three-layer encryption method for data security and provided a hypothetical method to secure the model parameters. Experimental results show that the proposed method achieves better encryption quality at the expense of slightly increased execution time. We also highlighted several open issues and challenges regarding the FLEP AI framework's realization.

Reproducibility in Machine Learning for Health

Machine learning algorithms designed to characterize, monitor, and intervene on human health (ML4H) are expected to perform safely and reliably when operating at scale, potentially outside strict human supervision. This requirement warrants a stricter attention to issues of reproducibility than other fields of machine learning. In this work, we conduct a systematic evaluation of over 100 recently published ML4H research papers along several dimensions related to reproducibility. We find that the field of ML4H compares poorly to more established machine learning fields, particularly concerning data and code accessibility. Finally, drawing from success in other fields of science, we propose recommendations to data providers, academic publishers, and the ML4H research community in order to promote reproducible research moving forward.

Adversarial Examples for Electrocardiograms

In recent years, the electrocardiogram (ECG) has seen a large diffusion in both medical and commercial applications, fueled by the rise of single-lead versions. Single-lead ECG can be embedded in medical devices and wearable products such as the injectable Medtronic Linq monitor, the iRhythm Ziopatch wearable monitor, and the Apple Watch Series 4. Recently, deep neural networks have been used to automatically analyze ECG tracings, outperforming even physicians specialized in cardiac electrophysiology in detecting certain rhythm irregularities. However, deep learning classifiers have been shown to be brittle to adversarial examples, which are examples created to look incontrovertibly belonging to a certain class to a human eye but contain subtle features that fool the classifier into misclassifying them into the wrong class. Very recently, adversarial examples have also been created for medical-related tasks. Yet, traditional attack methods to create adversarial examples, such as projected gradient descent (PGD) do not extend directly to ECG signals, as they generate examples that introduce square wave artifacts that are not physiologically plausible. Here, we developed a method to construct smoothed adversarial examples for single-lead ECG. First, we implemented a neural network model achieving state-of-the-art performance on the data from the 2017 PhysioNet/Computing-in-Cardiology Challenge for arrhythmia detection from single lead ECG classification. For this model, we utilized a new technique to generate smoothed examples to produce signals that are 1) indistinguishable to cardiologists from the original examples and 2) incorrectly classified by the neural network. Finally, we show that adversarial examples are not unique and provide a general technique to collate and perturb known adversarial examples to create new ones.

Learning Individualized Cardiovascular Responses from Large-scale Wearable Sensors Data

We consider the problem of modeling cardiovascular responses to physical activity and sleep changes captured by wearable sensors in free living conditions. We use an attentional convolutional neural network to learn parsimonious signatures of individual cardiovascular response from data recorded at the minute level resolution over several months on a cohort of 80k people. We demonstrate internal validity by showing that signatures generated on an individual's 2017 data generalize to predict minute-level heart rate from physical activity and sleep for the same individual in 2018, outperforming several time-series forecasting baselines. We also show external validity demonstrating that signatures outperform plain resting heart rate (RHR) in predicting variables associated with cardiovascular functions, such as age and Body Mass Index (BMI). We believe that the computed cardiovascular signatures have utility in monitoring cardiovascular health over time, including detecting abnormalities and quantifying recovery from acute events.

Spatial Coherence of Oriented White Matter Microstructure: Applications to White Matter Regions Associated with Genetic Similarity

We present a method to discover differences between populations with respect to the spatial coherence of their oriented white matter microstructure in arbitrarily shaped white matter regions. This method is applied to diffusion MRI scans of a subset of the Human Connectome Project dataset: 57 pairs of monozygotic and 52 pairs of dizygotic twins. After controlling for morphological similarity between twins, we identify 3.7% of all white matter as being associated with genetic similarity (35.1k voxels, $p < 10^{-4}$, false discovery rate 1.5%), 75% of which spatially clusters into twenty-two contiguous white matter regions. Furthermore, we show that the orientation similarity within these regions generalizes to a subset of 47 pairs of non-twin siblings, and show that these siblings are on average as similar as dizygotic twins. The regions are located in deep white matter including the superior longitudinal fasciculus, the optic radiations, the middle cerebellar peduncle, the corticospinal tract, and within the anterior temporal lobe, as well as the cerebellum, brain stem, and amygdalae. These results extend previous work using undirected fractional anisotrophy for measuring putative heritable influences in white matter. Our multidirectional extension better accounts for crossing fiber connections within voxels. This bottom up approach has at its basis a novel measurement of coherence within neighboring voxel dyads between subjects, and avoids some of the fundamental ambiguities encountered with tractographic approaches to white matter analysis that estimate global connectivity.

Intra-day Activity Better Predicts Chronic Conditions

In this work we investigate intra-day patterns of activity on a population of 7,261 users of mobile health wearable devices and apps. We show that: (1) using intra-day step and sleep data recorded from passive trackers significantly improves classification performance on self-reported chronic conditions related to mental health and nervous system disorders, (2) Convolutional Neural Networks achieve top classification performance vs. baseline models when trained directly on multivariate time series of activity data, and (3) jointly predicting all condition classes via multi-task learning can be leveraged to extract features that generalize across data sets and achieve the highest classification performance.