Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

The aggressiveness of prostate cancer, the most common cancer in men worldwide, is primarily assessed based on histopathological data using the Gleason scoring system. While artificial intelligence (AI) has shown promise in accurately predicting Gleason scores, these predictions often lack inherent explainability, potentially leading to distrust in human-machine interactions. To address this issue, we introduce a novel dataset of 1,015 tissue microarray core images, annotated by an international group of 54 pathologists. The annotations provide detailed localized pattern descriptions for Gleason grading in line with international guidelines. Utilizing this dataset, we develop an inherently explainable AI system based on a U-Net architecture that provides predictions leveraging pathologists' terminology. This approach circumvents post-hoc explainability methods while maintaining or exceeding the performance of methods trained directly for Gleason pattern segmentation (Dice score: 0.713 $\pm$ 0.003 trained on explanations vs. 0.691 $\pm$ 0.010 trained on Gleason patterns). By employing soft labels during training, we capture the intrinsic uncertainty in the data, yielding strong results in Gleason pattern segmentation even in the context of high interobserver variability. With the release of this dataset, we aim to encourage further research into segmentation in medical tasks with high levels of subjectivity and to advance the understanding of pathologists' reasoning processes.

Explicit Inductive Inference using Large Language Models

Large Language Models (LLMs) are reported to hold undesirable attestation bias on inference tasks: when asked to predict if a premise P entails a hypothesis H, instead of considering H's conditional truthfulness entailed by P, LLMs tend to use the out-of-context truth label of H as a fragile proxy. In this paper, we propose a pipeline that exploits this bias to do explicit inductive inference. Our pipeline uses an LLM to transform a premise into a set of attested alternatives, and then aggregate answers of the derived new entailment inquiries to support the original inference prediction. On a directional predicate entailment benchmark, we demonstrate that by applying this simple pipeline, we can improve the overall performance of LLMs on inference and substantially alleviate the impact of their attestation bias.

Variational autoencoder-based neural network model compression

Variational Autoencoders (VAEs), as a form of deep generative model, have been widely used in recent years, and shown great great peformance in a number of different domains, including image generation and anomaly detection, etc.. This paper aims to explore neural network model compression method based on VAE. The experiment uses different neural network models for MNIST recognition as compression targets, including Feedforward Neural Network (FNN), Convolutional Neural Network (CNN), Recurrent Neural Network (RNN) and Long Short-Term Memory (LSTM). These models are the most basic models in deep learning, and other more complex and advanced models are based on them or inherit their features and evolve. In the experiment, the first step is to train the models mentioned above, each trained model will have different accuracy and number of total parameters. And then the variants of parameters for each model are processed as training data in VAEs separately, and the trained VAEs are tested by the true model parameters. The experimental results show that using the latent space as a representation of the model compression can improve the compression rate compared to some traditional methods such as pruning and quantization, meanwhile the accuracy is not greatly affected using the model parameters reconstructed based on the latent space. In the future, a variety of different large-scale deep learning models will be used more widely, so exploring different ways to save time and space on saving or transferring models will become necessary, and the use of VAE in this paper can provide a basis for these further explorations.

A Multi-Faceted Evaluation Framework for Assessing Synthetic Data Generated by Large Language Models

The rapid advancements in generative AI and large language models (LLMs) have opened up new avenues for producing synthetic data, particularly in the realm of structured tabular formats, such as product reviews. Despite the potential benefits, concerns regarding privacy leakage have surfaced, especially when personal information is utilized in the training datasets. In addition, there is an absence of a comprehensive evaluation framework capable of quantitatively measuring the quality of the generated synthetic data and their utility for downstream tasks. In response to this gap, we introduce SynEval, an open-source evaluation framework designed to assess the fidelity, utility, and privacy preservation of synthetically generated tabular data via a suite of diverse evaluation metrics. We validate the efficacy of our proposed framework - SynEval - by applying it to synthetic product review data generated by three state-of-the-art LLMs: ChatGPT, Claude, and Llama. Our experimental findings illuminate the trade-offs between various evaluation metrics in the context of synthetic data generation. Furthermore, SynEval stands as a critical instrument for researchers and practitioners engaged with synthetic tabular data,, empowering them to judiciously determine the suitability of the generated data for their specific applications, with an emphasis on upholding user privacy.

Transfer learning-assisted inverse modeling in nanophotonics based on mixture density networks

The simulation of nanophotonic structures relies on electromagnetic solvers, which play a crucial role in understanding their behavior. However, these solvers often come with a significant computational cost, making their application in design tasks, such as optimization, impractical. To address this challenge, machine learning techniques have been explored for accurate and efficient modeling and design of photonic devices. Deep neural networks, in particular, have gained considerable attention in this field. They can be used to create both forward and inverse models. An inverse modeling approach avoids the need for coupling a forward model with an optimizer and directly performs the prediction of the optimal design parameters values. In this paper, we propose an inverse modeling method for nanophotonic structures, based on a mixture density network model enhanced by transfer learning. Mixture density networks can predict multiple possible solutions at a time including their respective importance as Gaussian distributions. However, multiple challenges exist for mixture density network models. An important challenge is that an upper bound on the number of possible simultaneous solutions needs to be specified in advance. Also, another challenge is that the model parameters must be jointly optimized, which can result computationally expensive. Moreover, optimizing all parameters simultaneously can be numerically unstable and can lead to degenerate predictions. The proposed approach allows overcoming these limitations using transfer learning-based techniques, while preserving a high accuracy in the prediction capability of the design solutions given an optical response as an input. A dimensionality reduction step is also explored. Numerical results validate the proposed method.

Sources of Hallucination by Large Language Models on Inference Tasks

Large Language Models (LLMs) are claimed to be capable of Natural Language Inference (NLI), necessary for applied tasks like question answering and summarization, yet this capability is under-explored. We present a series of behavioral studies on several LLM families (LLaMA, GPT-3.5, and PaLM) which probe their behavior using controlled experiments. We establish two factors which predict much of their performance, and propose that these are major sources of hallucination in generative LLM. First, the most influential factor is memorization of the training data. We show that models falsely label NLI test samples as entailing when the hypothesis is attested in the training text, regardless of the premise. We further show that named entity IDs are used as "indices" to access the memorized data. Second, we show that LLMs exploit a further corpus-based heuristic using the relative frequencies of words. We show that LLMs score significantly worse on NLI test samples which do not conform to these factors than those which do; we also discuss a tension between the two factors, and a performance trade-off.

Marginalia and machine learning: Handwritten text recognition for Marginalia Collections

The pressing need for digitization of historical document collections has led to a strong interest in designing computerised image processing methods for automatic handwritten text recognition (HTR). Handwritten text possesses high variability due to different writing styles, languages and scripts. Training an accurate and robust HTR system calls for data-efficient approaches due to the unavailability of sufficient amounts of annotated multi-writer text. A case study on an ongoing project ``Marginalia and Machine Learning" is presented here that focuses on automatic detection and recognition of handwritten marginalia texts i.e., text written in margins or handwritten notes. Faster R-CNN network is used for detection of marginalia and AttentionHTR is used for word recognition. The data comes from early book collections (printed) found in the Uppsala University Library, with handwritten marginalia texts. Source code and pretrained models are available at https://github.com/ektavats/Project-Marginalia.

Tea: Program Repair Using Neural Network Based on Program Information Attention Matrix

The advance in machine learning (ML)-driven natural language process (NLP) points a promising direction for automatic bug fixing for software programs, as fixing a buggy program can be transformed to a translation task. While software programs contain much richer information than one-dimensional natural language documents, pioneering work on using ML-driven NLP techniques for automatic program repair only considered a limited set of such information. We hypothesize that more comprehensive information of software programs, if appropriately utilized, can improve the effectiveness of ML-driven NLP approaches in repairing software programs. As the first step towards proving this hypothesis, we propose a unified representation to capture the syntax, data flow, and control flow aspects of software programs, and devise a method to use such a representation to guide the transformer model from NLP in better understanding and fixing buggy programs. Our preliminary experiment confirms that the more comprehensive information of software programs used, the better ML-driven NLP techniques can perform in fixing bugs in these programs.