BURExtract-Llama: An LLM for Clinical Concept Extraction in Breast Ultrasound Reports

Breast ultrasound is essential for detecting and diagnosing abnormalities, with radiology reports summarizing key findings like lesion characteristics and malignancy assessments. Extracting this critical information is challenging due to the unstructured nature of these reports, with varied linguistic styles and inconsistent formatting. While proprietary LLMs like GPT-4 are effective, they are costly and raise privacy concerns when handling protected health information. This study presents a pipeline for developing an in-house LLM to extract clinical information from radiology reports. We first use GPT-4 to create a small labeled dataset, then fine-tune a Llama3-8B model on it. Evaluated on clinician-annotated reports, our model achieves an average F1 score of 84.6%, which is on par with GPT-4. Our findings demonstrate the feasibility of developing an in-house LLM that not only matches GPT-4's performance but also offers cost reductions and enhanced data privacy.

PFID: Privacy First Inference Delegation Framework for LLMs

This paper introduces a novel privacy-preservation framework named PFID for LLMs that addresses critical privacy concerns by localizing user data through model sharding and singular value decomposition. When users are interacting with LLM systems, their prompts could be subject to being exposed to eavesdroppers within or outside LLM system providers who are interested in collecting users' input. In this work, we proposed a framework to camouflage user input, so as to alleviate privacy issues. Our framework proposes to place model shards on the client and the public server, we sent compressed hidden states instead of prompts to and from servers. Clients have held back information that can re-privatized the hidden states so that overall system performance is comparable to traditional LLMs services. Our framework was designed to be communication efficient, computation can be delegated to the local client so that the server's computation burden can be lightened. We conduct extensive experiments on machine translation tasks to verify our framework's performance.

Can We Trust LLMs? Mitigate Overconfidence Bias in LLMs through Knowledge Transfer

The study explores mitigating overconfidence bias in LLMs to improve their reliability. We introduce a knowledge transfer (KT) method utilizing chain of thoughts, where "big" LLMs impart knowledge to "small" LLMs via detailed, sequential reasoning paths. This method uses advanced reasoning of larger models to fine-tune smaller models, enabling them to produce more accurate predictions with calibrated confidence. Experimental evaluation using multiple-choice questions and sentiment analysis across diverse datasets demonstrated the KT method's superiority over the vanilla and question-answer pair (QA) fine-tuning methods. The most significant improvement in three key metrics, where the KT method outperformed the vanilla and QA methods by an average of 55.3% and 43.1%, respectively. These findings underscore the KT method's potential in enhancing model trustworthiness and accuracy, offering precise outputs with well-matched confidence levels across various contexts.

PRCA: Fitting Black-Box Large Language Models for Retrieval Question Answering via Pluggable Reward-Driven Contextual Adapter

The Retrieval Question Answering (ReQA) task employs the retrieval-augmented framework, composed of a retriever and generator. The generator formulates the answer based on the documents retrieved by the retriever. Incorporating Large Language Models (LLMs) as generators is beneficial due to their advanced QA capabilities, but they are typically too large to be fine-tuned with budget constraints while some of them are only accessible via APIs. To tackle this issue and further improve ReQA performance, we propose a trainable Pluggable Reward-Driven Contextual Adapter (PRCA), keeping the generator as a black box. Positioned between the retriever and generator in a Pluggable manner, PRCA refines the retrieved information by operating in a token-autoregressive strategy via maximizing rewards of the reinforcement learning phase. Our experiments validate PRCA's effectiveness in enhancing ReQA performance on three datasets by up to 20% improvement to fit black-box LLMs into existing frameworks, demonstrating its considerable potential in the LLMs era.