CSG: A Context-Semantic Guided Diffusion Approach in De Novo Musculoskeletal Ultrasound Image Generation

The use of synthetic images in medical imaging Artificial Intelligence (AI) solutions has been shown to be beneficial in addressing the limited availability of diverse, unbiased, and representative data. Despite the extensive use of synthetic image generation methods, controlling the semantics variability and context details remains challenging, limiting their effectiveness in producing diverse and representative medical image datasets. In this work, we introduce a scalable semantic and context-conditioned generative model, coined CSG (Context-Semantic Guidance). This dual conditioning approach allows for comprehensive control over both structure and appearance, advancing the synthesis of realistic and diverse ultrasound images. We demonstrate the ability of CSG to generate findings (pathological anomalies) in musculoskeletal (MSK) ultrasound images. Moreover, we test the quality of the synthetic images using a three-fold validation protocol. The results show that the synthetic images generated by CSG improve the performance of semantic segmentation models, exhibit enhanced similarity to real images compared to the baseline methods, and are undistinguishable from real images according to a Turing test. Furthermore, we demonstrate an extension of the CSG that allows enhancing the variability space of images by synthetically generating augmentations of anatomical geometries and textures.

Pristine annotations-based multi-modal trained artificial intelligence solution to triage chest X-ray for COVID-19

The COVID-19 pandemic continues to spread and impact the well-being of the global population. The front-line modalities including computed tomography (CT) and X-ray play an important role for triaging COVID patients. Considering the limited access of resources (both hardware and trained personnel) and decontamination considerations, CT may not be ideal for triaging suspected subjects. Artificial intelligence (AI) assisted X-ray based applications for triaging and monitoring require experienced radiologists to identify COVID patients in a timely manner and to further delineate the disease region boundary are seen as a promising solution. Our proposed solution differs from existing solutions by industry and academic communities, and demonstrates a functional AI model to triage by inferencing using a single x-ray image, while the deep-learning model is trained using both X-ray and CT data. We report on how such a multi-modal training improves the solution compared to X-ray only training. The multi-modal solution increases the AUC (area under the receiver operating characteristic curve) from 0.89 to 0.93 and also positively impacts the Dice coefficient (0.59 to 0.62) for localizing the pathology. To the best our knowledge, it is the first X-ray solution by leveraging multi-modal information for the development.

FastEstimator: A Deep Learning Library for Fast Prototyping and Productization

As the complexity of state-of-the-art deep learning models increases by the month, implementation, interpretation, and traceability become ever-more-burdensome challenges for AI practitioners around the world. Several AI frameworks have risen in an effort to stem this tide, but the steady advance of the field has begun to test the bounds of their flexibility, expressiveness, and ease of use. To address these concerns, we introduce a radically flexible high-level open source deep learning framework for both research and industry. We introduce FastEstimator.

AI Assisted Annotator using Reinforcement Learning

Healthcare data suffers from both noise and lack of ground truth. The cost of data increases as it is cleaned and annotated in healthcare. Unlike other data sets, medical data annotation, which is critical to accurate ground truth, requires medical domain expertise for a better patient outcome. In this work, we report on the use of reinforcement learning to mimic the decision making process of annotators for medical events, to automate annotation and labelling. The reinforcement agent learns to annotate alarm data based on annotations done by an expert. Our method shows promising results on medical alarm data sets. We trained DQN and A2C agents using the data from monitoring devices annotated by an expert. Initial results from these RL agents learning the expert annotation behavior are promising. The A2C agent performs better in terms of learning the sparse events in a given state, thereby choosing more right actions compared to DQN agent. To the best of our knowledge, this is the first reinforcement learning application for the automation of medical events annotation, which has far-reaching practical use.