Video Denoising in Fluorescence Guided Surgery

Fluorescence guided surgery (FGS) is a promising surgical technique that gives surgeons a unique view of tissue that is used to guide their practice by delineating tissue types and diseased areas. As new fluorescent contrast agents are developed that have low fluorescent photon yields, it becomes increasingly important to develop computational models to allow FGS systems to maintain good video quality in real time environments. To further complicate this task, FGS has a difficult bias noise term from laser leakage light (LLL) that represents unfiltered excitation light that can be on the order of the fluorescent signal. Most conventional video denoising methods focus on zero mean noise, and non-causal processing, both of which are violated in FGS. Luckily in FGS, often a co-located reference video is also captured which we use to simulate the LLL and assist in the denoising processes. In this work, we propose an accurate noise simulation pipeline that includes LLL and propose three baseline deep learning based algorithms for FGS video denoising.

Sparsity aware coding for single photon sensitive vision using Selective Sensing

Optical coding has been widely adopted to improve the imaging techniques. Traditional coding strategies developed under additive Gaussian noise fail to perform optimally in the presence of Poisson noise. It has been observed in previous studies that coding performance varies significantly between these two noise models. In this work, we introduce a novel approach called selective sensing, which leverages training data to learn priors and optimizes the coding strategies for downstream classification tasks. By adapting to the specific characteristics of photon-counting sensors, the proposed method aims to improve coding performance under Poisson noise and enhance overall classification accuracy. Experimental and simulated results demonstrate the effectiveness of selective sensing in comparison to traditional coding strategies, highlighting its potential for practical applications in photon counting scenarios where Poisson noise are prevalent.

Virtual Mirrors: Non-Line-of-Sight Imaging Beyond the Third Bounce

Non-line-of-sight (NLOS) imaging methods are capable of reconstructing complex scenes that are not visible to an observer using indirect illumination. However, they assume only third-bounce illumination, so they are currently limited to single-corner configurations, and present limited visibility when imaging surfaces at certain orientations. To reason about and tackle these limitations, we make the key observation that planar diffuse surfaces behave specularly at wavelengths used in the computational wave-based NLOS imaging domain. We call such surfaces virtual mirrors. We leverage this observation to expand the capabilities of NLOS imaging using illumination beyond the third bounce, addressing two problems: imaging single-corner objects at limited visibility angles, and imaging objects hidden behind two corners. To image objects at limited visibility angles, we first analyze the reflections of the known illuminated point on surfaces of the scene as an estimator of the position and orientation of objects with limited visibility. We then image those limited visibility objects by computationally building secondary apertures at other surfaces that observe the target object from a direct visibility perspective. Beyond single-corner NLOS imaging, we exploit the specular behavior of virtual mirrors to image objects hidden behind a second corner by imaging the space behind such virtual mirrors, where the mirror image of objects hidden around two corners is formed. No specular surfaces were involved in the making of this paper.

Physics to the Rescue: Deep Non-line-of-sight Reconstruction for High-speed Imaging

Computational approach to imaging around the corner, or non-line-of-sight (NLOS) imaging, is becoming a reality thanks to major advances in imaging hardware and reconstruction algorithms. A recent development towards practical NLOS imaging, Nam et al. demonstrated a high-speed non-confocal imaging system that operates at 5Hz, 100x faster than the prior art. This enormous gain in acquisition rate, however, necessitates numerous approximations in light transport, breaking many existing NLOS reconstruction methods that assume an idealized image formation model. To bridge the gap, we present a novel deep model that incorporates the complementary physics priors of wave propagation and volume rendering into a neural network for high-quality and robust NLOS reconstruction. This orchestrated design regularizes the solution space by relaxing the image formation model, resulting in a deep model that generalizes well on real captures despite being exclusively trained on synthetic data. Further, we devise a unified learning framework that enables our model to be flexibly trained using diverse supervision signals, including target intensity images or even raw NLOS transient measurements. Once trained, our model renders both intensity and depth images at inference time in a single forward pass, capable of processing more than 5 captures per second on a high-end GPU. Through extensive qualitative and quantitative experiments, we show that our method outperforms prior physics and learning based approaches on both synthetic and real measurements. We anticipate that our method along with the fast capturing system will accelerate future development of NLOS imaging for real world applications that require high-speed imaging.

Towards Non-Line-of-Sight Photography

Non-line-of-sight (NLOS) imaging is based on capturing the multi-bounce indirect reflections from the hidden objects. Active NLOS imaging systems rely on the capture of the time of flight of light through the scene, and have shown great promise for the accurate and robust reconstruction of hidden scenes without the need for specialized scene setups and prior assumptions. Despite that existing methods can reconstruct 3D geometries of the hidden scene with excellent depth resolution, accurately recovering object textures and appearance with high lateral resolution remains an challenging problem. In this work, we propose a new problem formulation, called NLOS photography, to specifically address this deficiency. Rather than performing an intermediate estimate of the 3D scene geometry, our method follows a data-driven approach and directly reconstructs 2D images of a NLOS scene that closely resemble the pictures taken with a conventional camera from the location of the relay wall. This formulation largely simplifies the challenging reconstruction problem by bypassing the explicit modeling of 3D geometry, and enables the learning of a deep model with a relatively small training dataset. The results are NLOS reconstructions of unprecedented lateral resolution and image quality.

Passive Inter-Photon Imaging

Digital camera pixels measure image intensities by converting incident light energy into an analog electrical current, and then digitizing it into a fixed-width binary representation. This direct measurement method, while conceptually simple, suffers from limited dynamic range and poor performance under extreme illumination -- electronic noise dominates under low illumination, and pixel full-well capacity results in saturation under bright illumination. We propose a novel intensity cue based on measuring inter-photon timing, defined as the time delay between detection of successive photons. Based on the statistics of inter-photon times measured by a time-resolved single-photon sensor, we develop theory and algorithms for a scene brightness estimator which works over extreme dynamic range; we experimentally demonstrate imaging scenes with a dynamic range of over ten million to one. The proposed techniques, aided by the emergence of single-photon sensors such as single-photon avalanche diodes (SPADs) with picosecond timing resolution, will have implications for a wide range of imaging applications: robotics, consumer photography, astronomy, microscopy and biomedical imaging.

Virtual light transport matrices for non-line-of-sight imaging

The light transport matrix (LTM) is an instrumental tool in line-of-sight (LOS) imaging, describing how light interacts with the scene and enabling applications such as relighting or separation of illumination components. We introduce a framework to estimate the LTM of non-line-of-sight (NLOS) scenarios, coupling recent virtual forward light propagation models for NLOS imaging with the LOS light transport equation. We design computational projector-camera setups, and use these virtual imaging systems to estimate the transport matrix of hidden scenes. We introduce the specific illumination functions to compute the different elements of the matrix, overcoming the challenging wide-aperture conditions of NLOS setups. Our NLOS light transport matrix allows us to (re)illuminate specific locations of a hidden scene, and separate direct, first-order indirect, and higher-order indirect illumination of complex cluttered hidden scenes, similar to existing LOS techniques.

iToF2dToF: A Robust and Flexible Representation for Data-Driven Time-of-Flight Imaging

Indirect Time-of-Flight (iToF) cameras are a promising depth sensing technology. However, they are prone to errors caused by multi-path interference (MPI) and low signal-to-noise ratio (SNR). Traditional methods, after denoising, mitigate MPI by estimating a transient image that encodes depths. Recently, data-driven methods that jointly denoise and mitigate MPI have become state-of-the-art without using the intermediate transient representation. In this paper, we propose to revisit the transient representation. Using data-driven priors, we interpolate/extrapolate iToF frequencies and use them to estimate the transient image. Given direct ToF (dToF) sensors capture transient images, we name our method iToF2dToF. The transient representation is flexible. It can be integrated with different rule-based depth sensing algorithms that are robust to low SNR and can deal with ambiguous scenarios that arise in practice (e.g., specular MPI, optical cross-talk). We demonstrate the benefits of iToF2dToF over previous methods in real depth sensing scenarios.

Real-time Non-line-of-Sight imaging of dynamic scenes

Non-Line-of-Sight (NLOS) imaging aims at recovering the 3D geometry of objects that are hidden from the direct line of sight. In the past, this method has suffered from the weak available multibounce signal limiting scene size, capture speed, and reconstruction quality. While algorithms capable of reconstructing scenes at several frames per second have been demonstrated, real-time NLOS video has only been demonstrated for retro-reflective objects where the NLOS signal strength is enhanced by 4 orders of magnitude or more. Furthermore, it has also been noted that the signal-to-noise ratio of reconstructions in NLOS methods drops quickly with distance and past reconstructions, therefore, have been limited to small scenes with depths of few meters. Actual models of noise and resolution in the scene have been simplistic, ignoring many of the complexities of the problem. We show that SPAD (Single-Photon Avalanche Diode) array detectors with a total of just 28 pixels combined with a specifically extended Phasor Field reconstruction algorithm can reconstruct live real-time videos of non-retro-reflective NLOS scenes. We provide an analysis of the Signal-to-Noise-Ratio (SNR) of our reconstructions and show that for our method it is possible to reconstruct the scene such that SNR, motion blur, angular resolution, and depth resolution are all independent of scene size suggesting that reconstruction of very large scenes may be possible. In the future, the light efficiency for NLOS imaging systems can be improved further by adding more pixels to the sensor array.

Super-Resolution Remote Imaging using Time Encoded Remote Apertures

Imaging of scenes using light or other wave phenomena is subject to the diffraction limit. The spatial profile of a wave propagating between a scene and the imaging system is distorted by diffraction resulting in a loss of resolution that is proportional with traveled distance. We show here that it is possible to reconstruct sparse scenes from the temporal profile of the wave-front using only one spatial pixel or a spatial average. The temporal profile of the wave is not affected by diffraction yielding an imaging method that can in theory achieve wavelength scale resolution independent of distance from the scene.