Vision Transformers with Autoencoders and Explainable AI for Cancer Patient Risk Stratification Using Whole Slide Imaging

Cancer remains one of the leading causes of mortality worldwide, necessitating accurate diagnosis and prognosis. Whole Slide Imaging (WSI) has become an integral part of clinical workflows with advancements in digital pathology. While various studies have utilized WSIs, their extracted features may not fully capture the most relevant pathological information, and their lack of interpretability limits clinical adoption. In this paper, we propose PATH-X, a framework that integrates Vision Transformers (ViT) and Autoencoders with SHAP (Shapley Additive Explanations) to enhance model explainability for patient stratification and risk prediction using WSIs from The Cancer Genome Atlas (TCGA). A representative image slice is selected from each WSI, and numerical feature embeddings are extracted using Google's pre-trained ViT. These features are then compressed via an autoencoder and used for unsupervised clustering and classification tasks. Kaplan-Meier survival analysis is applied to evaluate stratification into two and three risk groups. SHAP is used to identify key contributing features, which are mapped onto histopathological slices to provide spatial context. PATH-X demonstrates strong performance in breast and glioma cancers, where a sufficient number of WSIs enabled robust stratification. However, performance in lung cancer was limited due to data availability, emphasizing the need for larger datasets to enhance model reliability and clinical applicability.

FedSAF: A Federated Learning Framework for Enhanced Gastric Cancer Detection and Privacy Preservation

Gastric cancer is one of the most commonly diagnosed cancers and has a high mortality rate. Due to limited medical resources, developing machine learning models for gastric cancer recognition provides an efficient solution for medical institutions. However, such models typically require large sample sizes for training and testing, which can challenge patient privacy. Federated learning offers an effective alternative by enabling model training across multiple institutions without sharing sensitive patient data. This paper addresses the limited sample size of publicly available gastric cancer data with a modified data processing method. This paper introduces FedSAF, a novel federated learning algorithm designed to improve the performance of existing methods, particularly in non-independent and identically distributed (non-IID) data scenarios. FedSAF incorporates attention-based message passing and the Fisher Information Matrix to enhance model accuracy, while a model splitting function reduces computation and transmission costs. Hyperparameter tuning and ablation studies demonstrate the effectiveness of this new algorithm, showing improvements in test accuracy on gastric cancer datasets, with FedSAF outperforming existing federated learning methods like FedAMP, FedAvg, and FedProx. The framework's robustness and generalization ability were further validated across additional datasets (SEED, BOT, FashionMNIST, and CIFAR-10), achieving high performance in diverse environments.

Enhancing Sentiment Analysis through Multimodal Fusion: A BERT-DINOv2 Approach

Multimodal sentiment analysis enhances conventional sentiment analysis, which traditionally relies solely on text, by incorporating information from different modalities such as images, text, and audio. This paper proposes a novel multimodal sentiment analysis architecture that integrates text and image data to provide a more comprehensive understanding of sentiments. For text feature extraction, we utilize BERT, a natural language processing model. For image feature extraction, we employ DINOv2, a vision-transformer-based model. The textual and visual latent features are integrated using proposed fusion techniques, namely the Basic Fusion Model, Self Attention Fusion Model, and Dual Attention Fusion Model. Experiments on three datasets, Memotion 7k dataset, MVSA single dataset, and MVSA multi dataset, demonstrate the viability and practicality of the proposed multimodal architecture.

Fine-Tuning LLMs for Reliable Medical Question-Answering Services

We present an advanced approach to medical question-answering (QA) services, using fine-tuned Large Language Models (LLMs) to improve the accuracy and reliability of healthcare information. Our study focuses on optimizing models like LLaMA-2 and Mistral, which have shown great promise in delivering precise, reliable medical answers. By leveraging comprehensive datasets, we applied fine-tuning techniques such as rsDoRA+ and ReRAG. rsDoRA+ enhances model performance through a combination of decomposed model weights, varied learning rates for low-rank matrices, and rank stabilization, leading to improved efficiency. ReRAG, which integrates retrieval on demand and question rewriting, further refines the accuracy of the responses. This approach enables healthcare providers to access fast, dependable information, aiding in more efficient decision-making and fostering greater patient trust. Our work highlights the potential of fine-tuned LLMs to significantly improve the quality and accessibility of medical information services, ultimately contributing to better healthcare outcomes for all.

Optimized Biomedical Question-Answering Services with LLM and Multi-BERT Integration

We present a refined approach to biomedical question-answering (QA) services by integrating large language models (LLMs) with Multi-BERT configurations. By enhancing the ability to process and prioritize vast amounts of complex biomedical data, this system aims to support healthcare professionals in delivering better patient outcomes and informed decision-making. Through innovative use of BERT and BioBERT models, combined with a multi-layer perceptron (MLP) layer, we enable more specialized and efficient responses to the growing demands of the healthcare sector. Our approach not only addresses the challenge of overfitting by freezing one BERT model while training another but also improves the overall adaptability of QA services. The use of extensive datasets, such as BioASQ and BioMRC, demonstrates the system's ability to synthesize critical information. This work highlights how advanced language models can make a tangible difference in healthcare, providing reliable and responsive tools for professionals to manage complex information, ultimately serving the broader goal of improved care and data-driven insights.

Optimisation of federated learning settings under statistical heterogeneity variations

Federated Learning (FL) enables local devices to collaboratively learn a shared predictive model by only periodically sharing model parameters with a central aggregator. However, FL can be disadvantaged by statistical heterogeneity produced by the diversity in each local devices data distribution, which creates different levels of Independent and Identically Distributed (IID) data. Furthermore, this can be more complex when optimising different combinations of FL parameters and choosing optimal aggregation. In this paper, we present an empirical analysis of different FL training parameters and aggregators over various levels of statistical heterogeneity on three datasets. We propose a systematic data partition strategy to simulate different levels of statistical heterogeneity and a metric to measure the level of IID. Additionally, we empirically identify the best FL model and key parameters for datasets of different characteristics. On the basis of these, we present recommended guidelines for FL parameters and aggregators to optimise model performance under different levels of IID and with different datasets

Integration of Self-Supervised BYOL in Semi-Supervised Medical Image Recognition

Image recognition techniques heavily rely on abundant labeled data, particularly in medical contexts. Addressing the challenges associated with obtaining labeled data has led to the prominence of self-supervised learning and semi-supervised learning, especially in scenarios with limited annotated data. In this paper, we proposed an innovative approach by integrating self-supervised learning into semi-supervised models to enhance medical image recognition. Our methodology commences with pre-training on unlabeled data utilizing the BYOL method. Subsequently, we merge pseudo-labeled and labeled datasets to construct a neural network classifier, refining it through iterative fine-tuning. Experimental results on three different datasets demonstrate that our approach optimally leverages unlabeled data, outperforming existing methods in terms of accuracy for medical image recognition.

Damage GAN: A Generative Model for Imbalanced Data

This study delves into the application of Generative Adversarial Networks (GANs) within the context of imbalanced datasets. Our primary aim is to enhance the performance and stability of GANs in such datasets. In pursuit of this objective, we introduce a novel network architecture known as Damage GAN, building upon the ContraD GAN framework which seamlessly integrates GANs and contrastive learning. Through the utilization of contrastive learning, the discriminator is trained to develop an unsupervised representation capable of distinguishing all provided samples. Our approach draws inspiration from the straightforward framework for contrastive learning of visual representations (SimCLR), leading to the formulation of a distinctive loss function. We also explore the implementation of self-damaging contrastive learning (SDCLR) to further enhance the optimization of the ContraD GAN model. Comparative evaluations against baseline models including the deep convolutional GAN (DCGAN) and ContraD GAN demonstrate the evident superiority of our proposed model, Damage GAN, in terms of generated image distribution, model stability, and image quality when applied to imbalanced datasets.

ResNLS: An Improved Model for Stock Price Forecasting

Stock prices forecasting has always been a challenging task. Although many research projects adopt machine learning and deep learning algorithms to address the problem, few of them pay attention to the varying degrees of dependencies between stock prices. In this paper we introduce a hybrid model that improves stock price prediction by emphasizing the dependencies between adjacent stock prices. The proposed model, ResNLS, is mainly composed of two neural architectures, ResNet and LSTM. ResNet serves as a feature extractor to identify dependencies between stock prices across time windows, while LSTM analyses the initial time-series data with the combination of dependencies which considered as residuals. In predicting the SSE Composite Index, our experiment reveals that when the closing price data for the previous 5 consecutive trading days is used as the input, the performance of the model (ResNLS-5) is optimal compared to those with other inputs. Furthermore, ResNLS-5 outperforms vanilla CNN, RNN, LSTM, and BiLSTM models in terms of prediction accuracy. It also demonstrates at least a 20% improvement over the current state-of-the-art baselines. To verify whether ResNLS-5 can help clients effectively avoid risks and earn profits in the stock market, we construct a quantitative trading framework for back testing. The experimental results show that the trading strategy based on predictions from ResNLS-5 can successfully mitigate losses during declining stock prices and generate profits in the periods of rising stock prices.

Privacy-Preserving Personalized Fitness Recommender System (P3FitRec): A Multi-level Deep Learning Approach

Recommender systems have been successfully used in many domains with the help of machine learning algorithms. However, such applications tend to use multi-dimensional user data, which has raised widespread concerns about the breach of users privacy. Meanwhile, wearable technologies have enabled users to collect fitness-related data through embedded sensors to monitor their conditions or achieve personalized fitness goals. In this paper, we propose a novel privacy-aware personalized fitness recommender system. We introduce a multi-level deep learning framework that learns important features from a large-scale real fitness dataset that is collected from wearable IoT devices to derive intelligent fitness recommendations. Unlike most existing approaches, our approach achieves personalization by inferring the fitness characteristics of users from sensory data and thus minimizing the need for explicitly collecting user identity or biometric information, such as name, age, height, weight. In particular, our proposed models and algorithms predict (a) personalized exercise distance recommendations to help users to achieve target calories, (b) personalized speed sequence recommendations to adjust exercise speed given the nature of the exercise and the chosen route, and (c) personalized heart rate sequence to guide the user of the potential health status for future exercises. Our experimental evaluation on a real-world Fitbit dataset demonstrated high accuracy in predicting exercise distance, speed sequence, and heart rate sequence compared to similar studies. Furthermore, our approach is novel compared to existing studies as it does not require collecting and using users sensitive information, and thus it preserves the users privacy.