Hybrid Student-Teacher Large Language Model Refinement for Cancer Toxicity Symptom Extraction

Large Language Models (LLMs) offer significant potential for clinical symptom extraction, but their deployment in healthcare settings is constrained by privacy concerns, computational limitations, and operational costs. This study investigates the optimization of compact LLMs for cancer toxicity symptom extraction using a novel iterative refinement approach. We employ a student-teacher architecture, utilizing Zephyr-7b-beta and Phi3-mini-128 as student models and GPT-4o as the teacher, to dynamically select between prompt refinement, Retrieval-Augmented Generation (RAG), and fine-tuning strategies. Our experiments on 294 clinical notes covering 12 post-radiotherapy toxicity symptoms demonstrate the effectiveness of this approach. The RAG method proved most efficient, improving average accuracy scores from 0.32 to 0.73 for Zephyr-7b-beta and from 0.40 to 0.87 for Phi3-mini-128 during refinement. In the test set, both models showed an approximate 0.20 increase in accuracy across symptoms. Notably, this improvement was achieved at a cost 45 times lower than GPT-4o for Zephyr and 79 times lower for Phi-3. These results highlight the potential of iterative refinement techniques in enhancing the capabilities of compact LLMs for clinical applications, offering a balance between performance, cost-effectiveness, and privacy preservation in healthcare settings.

The Role of Functional Muscle Networks in Improving Hand Gesture Perception for Human-Machine Interfaces

Developing accurate hand gesture perception models is critical for various robotic applications, enabling effective communication between humans and machines and directly impacting neurorobotics and interactive robots. Recently, surface electromyography (sEMG) has been explored for its rich informational context and accessibility when combined with advanced machine learning approaches and wearable systems. The literature presents numerous approaches to boost performance while ensuring robustness for neurorobots using sEMG, often resulting in models requiring high processing power, large datasets, and less scalable solutions. This paper addresses this challenge by proposing the decoding of muscle synchronization rather than individual muscle activation. We study coherence-based functional muscle networks as the core of our perception model, proposing that functional synchronization between muscles and the graph-based network of muscle connectivity encode contextual information about intended hand gestures. This can be decoded using shallow machine learning approaches without the need for deep temporal networks. Our technique could impact myoelectric control of neurorobots by reducing computational burdens and enhancing efficiency. The approach is benchmarked on the Ninapro database, which contains 12 EMG signals from 40 subjects performing 17 hand gestures. It achieves an accuracy of 85.1%, demonstrating improved performance compared to existing methods while requiring much less computational power. The results support the hypothesis that a coherence-based functional muscle network encodes critical information related to gesture execution, significantly enhancing hand gesture perception with potential applications for neurorobotic systems and interactive machines.

An LSTM Feature Imitation Network for Hand Movement Recognition from sEMG Signals

Surface Electromyography (sEMG) is a non-invasive signal that is used in the recognition of hand movement patterns, the diagnosis of diseases, and the robust control of prostheses. Despite the remarkable success of recent end-to-end Deep Learning approaches, they are still limited by the need for large amounts of labeled data. To alleviate the requirement for big data, researchers utilize Feature Engineering, which involves decomposing the sEMG signal into several spatial, temporal, and frequency features. In this paper, we propose utilizing a feature-imitating network (FIN) for closed-form temporal feature learning over a 300ms signal window on Ninapro DB2, and applying it to the task of 17 hand movement recognition. We implement a lightweight LSTM-FIN network to imitate four standard temporal features (entropy, root mean square, variance, simple square integral). We then explore transfer learning capabilities by applying the pre-trained LSTM-FIN for tuning to a downstream hand movement recognition task. We observed that the LSTM network can achieve up to 99\% R2 accuracy in feature reconstruction and 80\% accuracy in hand movement recognition. Our results also showed that the model can be robustly applied for both within- and cross-subject movement recognition, as well as simulated low-latency environments. Overall, our work demonstrates the potential of the FIN modeling paradigm in data-scarce scenarios for sEMG signal processing.

The Broad Impact of Feature Imitation: Neural Enhancements Across Financial, Speech, and Physiological Domains

Initialization of neural network weights plays a pivotal role in determining their performance. Feature Imitating Networks (FINs) offer a novel strategy by initializing weights to approximate specific closed-form statistical features, setting a promising foundation for deep learning architectures. While the applicability of FINs has been chiefly tested in biomedical domains, this study extends its exploration into other time series datasets. Three different experiments are conducted in this study to test the applicability of imitating Tsallis entropy for performance enhancement: Bitcoin price prediction, speech emotion recognition, and chronic neck pain detection. For the Bitcoin price prediction, models embedded with FINs reduced the root mean square error by around 1000 compared to the baseline. In the speech emotion recognition task, the FIN-augmented model increased classification accuracy by over 3 percent. Lastly, in the CNP detection experiment, an improvement of about 7 percent was observed compared to established classifiers. These findings validate the broad utility and potency of FINs in diverse applications.

Feature Imitating Networks Enhance The Performance, Reliability And Speed Of Deep Learning On Biomedical Image Processing Tasks

Feature-Imitating-Networks (FINs) are neural networks with weights that are initialized to approximate closed-form statistical features. In this work, we perform the first-ever evaluation of FINs for biomedical image processing tasks. We begin by training a set of FINs to imitate six common radiomics features, and then compare the performance of networks with and without the FINs for three experimental tasks: COVID-19 detection from CT scans, brain tumor classification from MRI scans, and brain-tumor segmentation from MRI scans; we find that FINs provide best-in-class performance for all three tasks, while converging faster and more consistently when compared to networks with similar or greater representational power. The results of our experiments provide evidence that FINs may provide state-of-the-art performance for a variety of other biomedical image processing tasks.

MambaNet: A Hybrid Neural Network for Predicting the NBA Playoffs

In this paper, we present Mambanet: a hybrid neural network for predicting the outcomes of Basketball games. Contrary to other studies, which focus primarily on season games, this study investigates playoff games. MambaNet is a hybrid neural network architecture that processes a time series of teams' and players' game statistics and generates the probability of a team winning or losing an NBA playoff match. In our approach, we utilize Feature Imitating Networks to provide latent signal-processing feature representations of game statistics to further process with convolutional, recurrent, and dense neural layers. Three experiments using six different datasets are conducted to evaluate the performance and generalizability of our architecture against a wide range of previous studies. Our final method successfully predicted the AUC from 0.72 to 0.82, beating the best-performing baseline models by a considerable margin.

Nightly Automobile Claims Prediction from Telematics-Derived Features: A Multilevel Approach

In recent years it has become possible to collect GPS data from drivers and to incorporate this data into automobile insurance pricing for the driver. This data is continuously collected and processed nightly into metadata consisting of mileage and time summaries of each discrete trip taken, and a set of behavioral scores describing attributes of the trip (e.g, driver fatigue or driver distraction) so we examine whether it can be used to identify periods of increased risk by successfully classifying trips that occur immediately before a trip in which there was an incident leading to a claim for that driver. Identification of periods of increased risk for a driver is valuable because it creates an opportunity for intervention and, potentially, avoidance of a claim. We examine metadata for each trip a driver takes and train a classifier to predict whether \textit{the following trip} is one in which a claim occurs for that driver. By achieving a area under the receiver-operator characteristic above 0.6, we show that it is possible to predict claims in advance. Additionally, we compare the predictive power, as measured by the area under the receiver-operator characteristic of XGBoost classifiers trained to predict whether a driver will have a claim using exposure features such as driven miles, and those trained using behavioral features such as a computed speed score.

Feature Imitating Networks

In this paper, we introduce a novel approach to neural learning: the Feature-Imitating-Network (FIN). A FIN is a neural network with weights that are initialized to reliably approximate one or more closed-form statistical features, such as Shannon's entropy. In this paper, we demonstrate that FINs (and FIN ensembles) provide best-in-class performance for a variety of downstream signal processing and inference tasks, while using less data and requiring less fine-tuning compared to other networks of similar (or even greater) representational power. We conclude that FINs can help bridge the gap between domain experts and machine learning practitioners by enabling researchers to harness insights from feature-engineering to enhance the performance of contemporary representation learning approaches.

Fetal Gender Identification using Machine and Deep Learning Algorithms on Phonocardiogram Signals

Phonocardiogram (PCG) signal analysis is a critical, widely-studied technology to noninvasively analyze the heart's mechanical activity. Through evaluating heart sounds, this technology has been chiefly leveraged as a preliminary solution to automatically diagnose Cardiovascular diseases among adults; however, prenatal tasks such as fetal gender identification have been relatively less studied using fetal Phonocardiography (FPCG). In this work, we apply common PCG signal processing techniques on the gender-tagged Shiraz University Fetal Heart Sounds Database and study the applicability of previously proposed features in classifying fetal gender using both Machine Learning and Deep Learning models. Even though PCG data acquisition's cost-effectiveness and feasibility make it a convenient method of Fetal Heart Rate (FHR) monitoring, the contaminated nature of PCG signals with the noise of various types makes it a challenging modality. To address this problem, we experimented with both static and adaptive noise reduction techniques such as Low-pass filtering, Denoising Autoencoders, and Source Separators. We apply a wide range of previously proposed classifiers to our dataset and propose a novel ensemble method of Fetal Gender Identification (FGI). Our method substantially outperformed the baseline and reached up to 91% accuracy in classifying fetal gender of unseen subjects.

SupCL-Seq: Supervised Contrastive Learning for Downstream Optimized Sequence Representations

While contrastive learning is proven to be an effective training strategy in computer vision, Natural Language Processing (NLP) is only recently adopting it as a self-supervised alternative to Masked Language Modeling (MLM) for improving sequence representations. This paper introduces SupCL-Seq, which extends the supervised contrastive learning from computer vision to the optimization of sequence representations in NLP. By altering the dropout mask probability in standard Transformer architectures, for every representation (anchor), we generate augmented altered views. A supervised contrastive loss is then utilized to maximize the system's capability of pulling together similar samples (e.g., anchors and their altered views) and pushing apart the samples belonging to the other classes. Despite its simplicity, SupCLSeq leads to large gains in many sequence classification tasks on the GLUE benchmark compared to a standard BERTbase, including 6% absolute improvement on CoLA, 5.4% on MRPC, 4.7% on RTE and 2.6% on STSB. We also show consistent gains over self supervised contrastively learned representations, especially in non-semantic tasks. Finally we show that these gains are not solely due to augmentation, but rather to a downstream optimized sequence representation. Code: https://github.com/hooman650/SupCL-Seq