Touchstone Benchmark: Are We on the Right Way for Evaluating AI Algorithms for Medical Segmentation?

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks--which, differing from algorithms, are more flexible and can support different algorithms--including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

Label Critic: Design Data Before Models

As medical datasets rapidly expand, creating detailed annotations of different body structures becomes increasingly expensive and time-consuming. We consider that requesting radiologists to create detailed annotations is unnecessarily burdensome and that pre-existing AI models can largely automate this process. Following the spirit don't use a sledgehammer on a nut, we find that, rather than creating annotations from scratch, radiologists only have to review and edit errors if the Best-AI Labels have mistakes. To obtain the Best-AI Labels among multiple AI Labels, we developed an automatic tool, called Label Critic, that can assess label quality through tireless pairwise comparisons. Extensive experiments demonstrate that, when incorporated with our developed Image-Prompt pairs, pre-existing Large Vision-Language Models (LVLM), trained on natural images and texts, achieve 96.5% accuracy when choosing the best label in a pair-wise comparison, without extra fine-tuning. By transforming the manual annotation task (30-60 min/scan) into an automatic comparison task (15 sec/scan), we effectively reduce the manual efforts required from radiologists by an order of magnitude. When the Best-AI Labels are sufficiently accurate (81% depending on body structures), they will be directly adopted as the gold-standard annotations for the dataset, with lower-quality AI Labels automatically discarded. Label Critic can also check the label quality of a single AI Label with 71.8% accuracy when no alternatives are available for comparison, prompting radiologists to review and edit if the estimated quality is low (19% depending on body structures).

A Hybrid Federated Kernel Regularized Least Squares Algorithm

Federated learning is becoming an increasingly viable and accepted strategy for building machine learning models in critical privacy-preserving scenarios such as clinical settings. Often, the data involved is not limited to clinical data but also includes additional omics features (e.g. proteomics). Consequently, data is distributed not only across hospitals but also across omics centers, which are labs capable of generating such additional features from biosamples. This scenario leads to a hybrid setting where data is scattered both in terms of samples and features. In this hybrid setting, we present an efficient reformulation of the Kernel Regularized Least Squares algorithm, introduce two variants and validate them using well-established datasets. Lastly, we discuss security measures to defend against possible attacks.

Explanation is All You Need in Distillation: Mitigating Bias and Shortcut Learning

Bias and spurious correlations in data can cause shortcut learning, undermining out-of-distribution (OOD) generalization in deep neural networks. Most methods require unbiased data during training (and/or hyper-parameter tuning) to counteract shortcut learning. Here, we propose the use of explanation distillation to hinder shortcut learning. The technique does not assume any access to unbiased data, and it allows an arbitrarily sized student network to learn the reasons behind the decisions of an unbiased teacher, such as a vision-language model or a network processing debiased images. We found that it is possible to train a neural network with explanation (e.g by Layer Relevance Propagation, LRP) distillation only, and that the technique leads to high resistance to shortcut learning, surpassing group-invariant learning, explanation background minimization, and alternative distillation techniques. In the COLOURED MNIST dataset, LRP distillation achieved 98.2% OOD accuracy, while deep feature distillation and IRM achieved 92.1% and 60.2%, respectively. In COCO-on-Places, the undesirable generalization gap between in-distribution and OOD accuracy is only of 4.4% for LRP distillation, while the other two techniques present gaps of 15.1% and 52.1%, respectively.

Faster ISNet for Background Bias Mitigation on Deep Neural Networks

Image background features can constitute background bias (spurious correlations) and impact deep classifiers decisions, causing shortcut learning (Clever Hans effect) and reducing the generalization skill on real-world data. The concept of optimizing Layer-wise Relevance Propagation (LRP) heatmaps, to improve classifier behavior, was recently introduced by a neural network architecture named ISNet. It minimizes background relevance in LRP maps, to mitigate the influence of image background features on deep classifiers decisions, hindering shortcut learning and improving generalization. For each training image, the original ISNet produces one heatmap per possible class in the classification task, hence, its training time scales linearly with the number of classes. Here, we introduce reformulated architectures that allow the training time to become independent from this number, rendering the optimization process much faster. We challenged the enhanced models utilizing the MNIST dataset with synthetic background bias, and COVID-19 detection in chest X-rays, an application that is prone to shortcut learning due to background bias. The trained models minimized background attention and hindered shortcut learning, while retaining high accuracy. Considering external (out-of-distribution) test datasets, they consistently proved more accurate than multiple state-of-the-art deep neural network architectures, including a dedicated image semantic segmenter followed by a classifier. The architectures presented here represent a potentially massive improvement in training speed over the original ISNet, thus introducing LRP optimization into a gamut of applications that could not be feasibly handled by the original model.

Distributed Kernel K-Means for Large Scale Clustering

Clustering samples according to an effective metric and/or vector space representation is a challenging unsupervised learning task with a wide spectrum of applications. Among several clustering algorithms, k-means and its kernelized version have still a wide audience because of their conceptual simplicity and efficacy. However, the systematic application of the kernelized version of k-means is hampered by its inherent square scaling in memory with the number of samples. In this contribution, we devise an approximate strategy to minimize the kernel k-means cost function in which the trade-off between accuracy and velocity is automatically ruled by the available system memory. Moreover, we define an ad-hoc parallelization scheme well suited for hybrid cpu-gpu state-of-the-art parallel architectures. We proved the effectiveness both of the approximation scheme and of the parallelization method on standard UCI datasets and on molecular dynamics (MD) data in the realm of computational chemistry. In this applicative domain, clustering can play a key role for both quantitively estimating kinetics rates via Markov State Models or to give qualitatively a human compatible summarization of the underlying chemical phenomenon under study. For these reasons, we selected it as a valuable real-world application scenario.