Automating Adjudication of Cardiovascular Events Using Large Language Models

Cardiovascular events, such as heart attacks and strokes, remain a leading cause of mortality globally, necessitating meticulous monitoring and adjudication in clinical trials. This process, traditionally performed manually by clinical experts, is time-consuming, resource-intensive, and prone to inter-reviewer variability, potentially introducing bias and hindering trial progress. This study addresses these critical limitations by presenting a novel framework for automating the adjudication of cardiovascular events in clinical trials using Large Language Models (LLMs). We developed a two-stage approach: first, employing an LLM-based pipeline for event information extraction from unstructured clinical data and second, using an LLM-based adjudication process guided by a Tree of Thoughts approach and clinical endpoint committee (CEC) guidelines. Using cardiovascular event-specific clinical trial data, the framework achieved an F1-score of 0.82 for event extraction and an accuracy of 0.68 for adjudication. Furthermore, we introduce the CLEART score, a novel, automated metric specifically designed for evaluating the quality of AI-generated clinical reasoning in adjudicating cardiovascular events. This approach demonstrates significant potential for substantially reducing adjudication time and costs while maintaining high-quality, consistent, and auditable outcomes in clinical trials. The reduced variability and enhanced standardization also allow for faster identification and mitigation of risks associated with cardiovascular therapies.

Enhancing Large-scale UAV Route Planing with Global and Local Features via Reinforcement Graph Fusion

Numerous remarkable advancements have been made in accuracy, speed, and parallelism for solving the Unmanned Aerial Vehicle Route Planing (UAVRP). However, existing UAVRP solvers face challenges when attempting to scale effectively and efficiently for larger instances. In this paper, we present a generalization framework that enables current UAVRP solvers to robustly extend their capabilities to larger instances, accommodating up to 10,000 points, using widely recognized test sets. The UAVRP under a large number of patrol points is a typical large-scale TSP problem.Our proposed framework comprises three distinct steps. Firstly, we employ Delaunay triangulation to extract subgraphs from large instances while preserving global features. Secondly, we utilize an embedded TSP solver to obtain sub-results, followed by graph fusion. Finally, we implement a decoding strategy customizable to the user's requirements, resulting in high-quality solutions, complemented by a warming-up process for the heatmap. To demonstrate the flexibility of our approach, we integrate two representative TSP solvers into our framework and conduct a comprehensive comparative analysis against existing algorithms using large TSP benchmark datasets. The results unequivocally demonstrate that our framework efficiently scales existing TSP solvers to handle large instances and consistently outperforms state-of-the-art (SOTA) methods. Furthermore, since our proposed framework does not necessitate additional training or fine-tuning, we believe that its generality can significantly advance research on end-to-end UAVRP solvers, enabling the application of a broader range of methods to real-world scenarios.

NexusSplats: Efficient 3D Gaussian Splatting in the Wild

While 3D Gaussian Splatting (3DGS) has recently demonstrated remarkable rendering quality and efficiency in 3D scene reconstruction, it struggles with varying lighting conditions and incidental occlusions in real-world scenarios. To accommodate varying lighting conditions, existing 3DGS extensions apply color mapping to the massive Gaussian primitives with individually optimized appearance embeddings. To handle occlusions, they predict pixel-wise uncertainties via 2D image features for occlusion capture. Nevertheless, such massive color mapping and pixel-wise uncertainty prediction strategies suffer from not only additional computational costs but also coarse-grained lighting and occlusion handling. In this work, we propose a nexus kernel-driven approach, termed NexusSplats, for efficient and finer 3D scene reconstruction under complex lighting and occlusion conditions. In particular, NexusSplats leverages a novel light decoupling strategy where appearance embeddings are optimized based on nexus kernels instead of massive Gaussian primitives, thus accelerating reconstruction speeds while ensuring local color consistency for finer textures. Additionally, a Gaussian-wise uncertainty mechanism is developed, aligning 3D structures with 2D image features for fine-grained occlusion handling. Experimental results demonstrate that NexusSplats achieves state-of-the-art rendering quality while reducing reconstruction time by up to 70.4% compared to the current best in quality.

GMFlow: Global Motion-Guided Recurrent Flow for 6D Object Pose Estimation

6D object pose estimation is crucial for robotic perception and precise manipulation. Occlusion and incomplete object visibility are common challenges in this task, but existing pose refinement methods often struggle to handle these issues effectively. To tackle this problem, we propose a global motion-guided recurrent flow estimation method called GMFlow for pose estimation. GMFlow overcomes local ambiguities caused by occlusion or missing parts by seeking global explanations. We leverage the object's structural information to extend the motion of visible parts of the rigid body to its invisible regions. Specifically, we capture global contextual information through a linear attention mechanism and guide local motion information to generate global motion estimates. Furthermore, we introduce object shape constraints in the flow iteration process, making flow estimation suitable for pose estimation scenarios. Experiments on the LM-O and YCB-V datasets demonstrate that our method outperforms existing techniques in accuracy while maintaining competitive computational efficiency.

Phys4DGen: A Physics-Driven Framework for Controllable and Efficient 4D Content Generation from a Single Image

The task of 4D content generation involves creating dynamic 3D models that evolve over time in response to specific input conditions, such as images. Existing methods rely heavily on pre-trained video diffusion models to guide 4D content dynamics, but these approaches often fail to capture essential physical principles, as video diffusion models lack a robust understanding of real-world physics. Moreover, these models face challenges in providing fine-grained control over dynamics and exhibit high computational costs. In this work, we propose Phys4DGen, a novel, high-efficiency framework that generates physics-compliant 4D content from a single image with enhanced control capabilities. Our approach uniquely integrates physical simulations into the 4D generation pipeline, ensuring adherence to fundamental physical laws. Inspired by the human ability to infer physical properties visually, we introduce a Physical Perception Module (PPM) that discerns the material properties and structural components of the 3D object from the input image, facilitating accurate downstream simulations. Phys4DGen significantly accelerates the 4D generation process by eliminating iterative optimization steps in the dynamics modeling phase. It allows users to intuitively control the movement speed and direction of generated 4D content by adjusting external forces, achieving finely tunable, physically plausible animations. Extensive evaluations show that Phys4DGen outperforms existing methods in both inference speed and physical realism, producing high-quality, controllable 4D content.

An Efficient Dynamic Resource Allocation Framework for Evolutionary Bilevel Optimization

Bilevel optimization problems are characterized by an interactive hierarchical structure, where the upper level seeks to optimize its strategy while simultaneously considering the response of the lower level. Evolutionary algorithms are commonly used to solve complex bilevel problems in practical scenarios, but they face significant resource consumption challenges due to the nested structure imposed by the implicit lower-level optimality condition. This challenge becomes even more pronounced as problem dimensions increase. Although recent methods have enhanced bilevel convergence through task-level knowledge sharing, further efficiency improvements are still hindered by redundant lower-level iterations that consume excessive resources while generating unpromising solutions. To overcome this challenge, this paper proposes an efficient dynamic resource allocation framework for evolutionary bilevel optimization, named DRC-BLEA. Compared to existing approaches, DRC-BLEA introduces a novel competitive quasi-parallel paradigm, in which multiple lower-level optimization tasks, derived from different upper-level individuals, compete for resources. A continuously updated selection probability is used to prioritize execution opportunities to promising tasks. Additionally, a cooperation mechanism is integrated within the competitive framework to further enhance efficiency and prevent premature convergence. Experimental results compared with chosen state-of-the-art algorithms demonstrate the effectiveness of the proposed method. Specifically, DRC-BLEA achieves competitive accuracy across diverse problem sets and real-world scenarios, while significantly reducing the number of function evaluations and overall running time.

Cross-Modality Attack Boosted by Gradient-Evolutionary Multiform Optimization

In recent years, despite significant advancements in adversarial attack research, the security challenges in cross-modal scenarios, such as the transferability of adversarial attacks between infrared, thermal, and RGB images, have been overlooked. These heterogeneous image modalities collected by different hardware devices are widely prevalent in practical applications, and the substantial differences between modalities pose significant challenges to attack transferability. In this work, we explore a novel cross-modal adversarial attack strategy, termed multiform attack. We propose a dual-layer optimization framework based on gradient-evolution, facilitating efficient perturbation transfer between modalities. In the first layer of optimization, the framework utilizes image gradients to learn universal perturbations within each modality and employs evolutionary algorithms to search for shared perturbations with transferability across different modalities through secondary optimization. Through extensive testing on multiple heterogeneous datasets, we demonstrate the superiority and robustness of Multiform Attack compared to existing techniques. This work not only enhances the transferability of cross-modal adversarial attacks but also provides a new perspective for understanding security vulnerabilities in cross-modal systems.

Phy124: Fast Physics-Driven 4D Content Generation from a Single Image

4D content generation focuses on creating dynamic 3D objects that change over time. Existing methods primarily rely on pre-trained video diffusion models, utilizing sampling processes or reference videos. However, these approaches face significant challenges. Firstly, the generated 4D content often fails to adhere to real-world physics since video diffusion models do not incorporate physical priors. Secondly, the extensive sampling process and the large number of parameters in diffusion models result in exceedingly time-consuming generation processes. To address these issues, we introduce Phy124, a novel, fast, and physics-driven method for controllable 4D content generation from a single image. Phy124 integrates physical simulation directly into the 4D generation process, ensuring that the resulting 4D content adheres to natural physical laws. Phy124 also eliminates the use of diffusion models during the 4D dynamics generation phase, significantly speeding up the process. Phy124 allows for the control of 4D dynamics, including movement speed and direction, by manipulating external forces. Extensive experiments demonstrate that Phy124 generates high-fidelity 4D content with significantly reduced inference times, achieving stateof-the-art performance. The code and generated 4D content are available at the provided link: https://anonymous.4open.science/r/BBF2/.

Adversarial Learning for Neural PDE Solvers with Sparse Data

Neural network solvers for partial differential equations (PDEs) have made significant progress, yet they continue to face challenges related to data scarcity and model robustness. Traditional data augmentation methods, which leverage symmetry or invariance, impose strong assumptions on physical systems that often do not hold in dynamic and complex real-world applications. To address this research gap, this study introduces a universal learning strategy for neural network PDEs, named Systematic Model Augmentation for Robust Training (SMART). By focusing on challenging and improving the model's weaknesses, SMART reduces generalization error during training under data-scarce conditions, leading to significant improvements in prediction accuracy across various PDE scenarios. The effectiveness of the proposed method is demonstrated through both theoretical analysis and extensive experimentation. The code will be available.

Ask, Attend, Attack: A Effective Decision-Based Black-Box Targeted Attack for Image-to-Text Models

While image-to-text models have demonstrated significant advancements in various vision-language tasks, they remain susceptible to adversarial attacks. Existing white-box attacks on image-to-text models require access to the architecture, gradients, and parameters of the target model, resulting in low practicality. Although the recently proposed gray-box attacks have improved practicality, they suffer from semantic loss during the training process, which limits their targeted attack performance. To advance adversarial attacks of image-to-text models, this paper focuses on a challenging scenario: decision-based black-box targeted attacks where the attackers only have access to the final output text and aim to perform targeted attacks. Specifically, we formulate the decision-based black-box targeted attack as a large-scale optimization problem. To efficiently solve the optimization problem, a three-stage process \textit{Ask, Attend, Attack}, called \textit{AAA}, is proposed to coordinate with the solver. \textit{Ask} guides attackers to create target texts that satisfy the specific semantics. \textit{Attend} identifies the crucial regions of the image for attacking, thus reducing the search space for the subsequent \textit{Attack}. \textit{Attack} uses an evolutionary algorithm to attack the crucial regions, where the attacks are semantically related to the target texts of \textit{Ask}, thus achieving targeted attacks without semantic loss. Experimental results on transformer-based and CNN+RNN-based image-to-text models confirmed the effectiveness of our proposed \textit{AAA}.