Convolutional Neural Network Model Observers Discount Signal-like Anatomical Structures During Search in Virtual Digital Breast Tomosynthesis Phantoms

Model observers are computational tools to evaluate and optimize task-based medical image quality. Linear model observers, such as the Channelized Hotelling Observer (CHO), predict human accuracy in detection tasks with a few possible signal locations in clinical phantoms or real anatomic backgrounds. In recent years, Convolutional Neural Networks (CNNs) have been proposed as a new type of model observer. What is not well understood is what CNNs add over the more common linear model observer approaches. We compare the CHO and CNN detection accuracy to the radiologist's accuracy in searching for two types of signals (mass and microcalcification) embedded in 2D/3D breast tomosynthesis phantoms (DBT). We show that the CHO model's accuracy is comparable to the CNN's performance for a location-known-exactly detection task. However, for the search task with 2D/3D DBT phantoms, the CHO's detection accuracy was significantly lower than the CNN accuracy. A comparison to the radiologist's accuracy showed that the CNN but not the CHO could match or exceed the radiologist's accuracy in the 2D microcalcification and 3D mass search conditions. An analysis of the eye position showed that radiologists fixated more often and longer at the locations corresponding to CNN false positives. Most CHO false positives were the phantom's normal anatomy and were not fixated by radiologists. In conclusion, we show that CNNs can be used as an anthropomorphic model observer for the search task for which traditional linear model observers fail due to their inability to discount false positives arising from the anatomical backgrounds.

A deep Q-learning method for optimizing visual search strategies in backgrounds of dynamic noise

Humans process visual information with varying resolution (foveated visual system) and explore images by orienting through eye movements the high-resolution fovea to points of interest. The Bayesian ideal searcher (IS) that employs complete knowledge of task-relevant information optimizes eye movement strategy and achieves the optimal search performance. The IS can be employed as an important tool to evaluate the optimality of human eye movements, and potentially provide guidance to improve human observer visual search strategies. Najemnik and Geisler (2005) derived an IS for backgrounds of spatial 1/f noise. The corresponding template responses follow Gaussian distributions and the optimal search strategy can be analytically determined. However, the computation of the IS can be intractable when considering more realistic and complex backgrounds such as medical images. Modern reinforcement learning methods, successfully applied to obtain optimal policy for a variety of tasks, do not require complete knowledge of the background generating functions and can be potentially applied to anatomical backgrounds. An important first step is to validate the optimality of the reinforcement learning method. In this study, we investigate the ability of a reinforcement learning method that employs Q-network to approximate the IS. We demonstrate that the search strategy corresponding to the Q-network is consistent with the IS search strategy. The findings show the potential of the reinforcement learning with Q-network approach to estimate optimal eye movement planning with real anatomical backgrounds.

FoveaTer: Foveated Transformer for Image Classification

Many animals and humans process the visual field with a varying spatial resolution (foveated vision) and use peripheral processing to make eye movements and point the fovea to acquire high-resolution information about objects of interest. This architecture results in computationally efficient rapid scene exploration. Recent progress in vision Transformers has brought about new alternatives to the traditionally convolution-reliant computer vision systems. However, these models do not explicitly model the foveated properties of the visual system nor the interaction between eye movements and the classification task. We propose foveated Transformer (FoveaTer) model, which uses pooling regions and saccadic movements to perform object classification tasks using a vision Transformer architecture. Our proposed model pools the image features using squared pooling regions, an approximation to the biologically-inspired foveated architecture, and uses the pooled features as an input to a Transformer Network. It decides on the following fixation location based on the attention assigned by the Transformer to various locations from previous and present fixations. The model uses a confidence threshold to stop scene exploration, allowing to dynamically allocate more fixation/computational resources to more challenging images. We construct an ensemble model using our proposed model and unfoveated model, achieving an accuracy 1.36% below the unfoveated model with 22% computational savings. Finally, we demonstrate our model's robustness against adversarial attacks, where it outperforms the unfoveated model.

Comparing Visual Reasoning in Humans and AI

Recent advances in natural language processing and computer vision have led to AI models that interpret simple scenes at human levels. Yet, we do not have a complete understanding of how humans and AI models differ in their interpretation of more complex scenes. We created a dataset of complex scenes that contained human behaviors and social interactions. AI and humans had to describe the scenes with a sentence. We used a quantitative metric of similarity between scene descriptions of the AI/human and ground truth of five other human descriptions of each scene. Results show that the machine/human agreement scene descriptions are much lower than human/human agreement for our complex scenes. Using an experimental manipulation that occludes different spatial regions of the scenes, we assessed how machines and humans vary in utilizing regions of images to understand the scenes. Together, our results are a first step toward understanding how machines fall short of human visual reasoning with complex scenes depicting human behaviors.

Gaze Perception in Humans and CNN-Based Model

Making accurate inferences about other individuals' locus of attention is essential for human social interactions and will be important for AI to effectively interact with humans. In this study, we compare how a CNN (convolutional neural network) based model of gaze and humans infer the locus of attention in images of real-world scenes with a number of individuals looking at a common location. We show that compared to the model, humans' estimates of the locus of attention are more influenced by the context of the scene, such as the presence of the attended target and the number of individuals in the image.

Language-based Video Editing via Multi-Modal Multi-Level Transformer

Video editing tools are widely used nowadays for digital design. Although the demand for these tools is high, the prior knowledge required makes it difficult for novices to get started. Systems that could follow natural language instructions to perform automatic editing would significantly improve accessibility. This paper introduces the language-based video editing (LBVE) task, which allows the model to edit, guided by text instruction, a source video into a target video. LBVE contains two features: 1) the scenario of the source video is preserved instead of generating a completely different video; 2) the semantic is presented differently in the target video, and all changes are controlled by the given instruction. We propose a Multi-Modal Multi-Level Transformer (M$^3$L-Transformer) to carry out LBVE. The M$^3$L-Transformer dynamically learns the correspondence between video perception and language semantic at different levels, which benefits both the video understanding and video frame synthesis. We build three new datasets for evaluation, including two diagnostic and one from natural videos with human-labeled text. Extensive experimental results show that M$^3$L-Transformer is effective for video editing and that LBVE can lead to a new field toward vision-and-language research.

Medical Image Quality Metrics for Foveated Model Observers

A recently proposed model observer mimics the foveated nature of the human visual system by processing the entire image with varying spatial detail, executing eye movements and scrolling through slices. The model can predict how human search performance changes with signal type and modality (2D vs. 3D), yet its implementation is computationally expensive and time-consuming. Here, we evaluate various image quality metrics using extensions of the classic index of detectability expressions and assess foveated model observers for location-known exactly tasks. We evaluated foveated extensions of a Channelized Hotelling and Non-prewhitening model with an eye filter. The proposed methods involve calculating a model index of detectability (d') for each retinal eccentricity and combining these with a weighting function into a single detectability metric. We assessed different versions of the weighting function that varied in the required measurements of the human observers' search (no measurements, eye movement patterns, and size of the image and median search times). We show that the index of detectability across eccentricities weighted using the eye movement patterns of observers best predicted human performance in 2D vs. 3D search performance for a small microcalcification-like signal and a larger mass-like. The metric with weighting function based on median search times was the second best at predicting human results. The findings provide a set of model observer tools to evaluate image quality in the early stages of imaging system evaluation or design without implementing the more computationally complex foveated search model.

Assessment of Faster R-CNN in Man-Machine collaborative search

With the advent of modern expert systems driven by deep learning that supplement human experts (e.g. radiologists, dermatologists, surveillance scanners), we analyze how and when do such expert systems enhance human performance in a fine-grained small target visual search task. We set up a 2 session factorial experimental design in which humans visually search for a target with and without a Deep Learning (DL) expert system. We evaluate human changes of target detection performance and eye-movements in the presence of the DL system. We find that performance improvements with the DL system (computed via a Faster R-CNN with a VGG16) interacts with observer's perceptual abilities (e.g., sensitivity). The main results include: 1) The DL system reduces the False Alarm rate per Image on average across observer groups of both high/low sensitivity; 2) Only human observers with high sensitivity perform better than the DL system, while the low sensitivity group does not surpass individual DL system performance, even when aided with the DL system itself; 3) Increases in number of trials and decrease in viewing time were mainly driven by the DL system only for the low sensitivity group. 4) The DL system aids the human observer to fixate at a target by the 3rd fixation. These results provide insights of the benefits and limitations of deep learning systems that are collaborative or competitive with humans.

Object Detection Through Exploration With A Foveated Visual Field

We present a foveated object detector (FOD) as a biologically-inspired alternative to the sliding window (SW) approach which is the dominant method of search in computer vision object detection. Similar to the human visual system, the FOD has higher resolution at the fovea and lower resolution at the visual periphery. Consequently, more computational resources are allocated at the fovea and relatively fewer at the periphery. The FOD processes the entire scene, uses retino-specific object detection classifiers to guide eye movements, aligns its fovea with regions of interest in the input image and integrates observations across multiple fixations. Our approach combines modern object detectors from computer vision with a recent model of peripheral pooling regions found at the V1 layer of the human visual system. We assessed various eye movement strategies on the PASCAL VOC 2007 dataset and show that the FOD performs on par with the SW detector while bringing significant computational cost savings.

Can Peripheral Representations Improve Clutter Metrics on Complex Scenes?

Previous studies have proposed image-based clutter measures that correlate with human search times and/or eye movements. However, most models do not take into account the fact that the effects of clutter interact with the foveated nature of the human visual system: visual clutter further from the fovea has an increasing detrimental influence on perception. Here, we introduce a new foveated clutter model to predict the detrimental effects in target search utilizing a forced fixation search task. We use Feature Congestion (Rosenholtz et al.) as our non foveated clutter model, and we stack a peripheral architecture on top of Feature Congestion for our foveated model. We introduce the Peripheral Integration Feature Congestion (PIFC) coefficient, as a fundamental ingredient of our model that modulates clutter as a non-linear gain contingent on eccentricity. We finally show that Foveated Feature Congestion (FFC) clutter scores r(44) = -0.82 correlate better with target detection (hit rate) than regular Feature Congestion r(44) = -0.19 in forced fixation search. Thus, our model allows us to enrich clutter perception research by computing fixation specific clutter maps. A toolbox for creating peripheral architectures: Piranhas: Peripheral Architectures for Natural, Hybrid and Artificial Systems will be made available.