Large Neighborhood Search and Bitmask Dynamic Programming for Wireless Mobile Charging Electric Vehicle Routing Problems in Medical Transportation

The transition to electric vehicles (EVs) is critical to achieving sustainable transportation, but challenges such as limited driving range and insufficient charging infrastructure have hindered the widespread adoption of EVs, especially in time-sensitive logistics such as medical transportation. This paper presents a new model to break through this barrier by combining wireless mobile charging technology with optimization. We propose the Wireless Mobile Charging Electric Vehicle Routing Problem (WMC-EVRP), which enables Medical Transportation Electric Vehicles (MTEVs) to be charged while traveling via Mobile Charging Carts (MCTs). This eliminates the time wastage of stopping for charging and ensures uninterrupted operation of MTEVs for such time-sensitive transportation problems. However, in this problem, the decisions of these two types of heterogeneous vehicles are coupled with each other, which greatly increases the difficulty of vehicle routing optimizations. To address this complex problem, we develop a mathematical model and a tailored meta-heuristic algorithm that combines Bit Mask Dynamic Programming (BDP) and Large Neighborhood Search (LNS). The BDP approach efficiently optimizes charging strategies, while the LNS framework utilizes custom operators to optimize the MTEV routes under capacity and synchronization constraints. Our approach outperforms traditional solvers in providing solutions for medium and large instances. Using actual hospital locations in Singapore as data, we validated the practical applicability of the model through extensive experiments and provided important insights into minimizing costs and ensuring the timely delivery of healthcare services.

Mitigating Ambiguities in 3D Classification with Gaussian Splatting

3D classification with point cloud input is a fundamental problem in 3D vision. However, due to the discrete nature and the insufficient material description of point cloud representations, there are ambiguities in distinguishing wire-like and flat surfaces, as well as transparent or reflective objects. To address these issues, we propose Gaussian Splatting (GS) point cloud-based 3D classification. We find that the scale and rotation coefficients in the GS point cloud help characterize surface types. Specifically, wire-like surfaces consist of multiple slender Gaussian ellipsoids, while flat surfaces are composed of a few flat Gaussian ellipsoids. Additionally, the opacity in the GS point cloud represents the transparency characteristics of objects. As a result, ambiguities in point cloud-based 3D classification can be mitigated utilizing GS point cloud as input. To verify the effectiveness of GS point cloud input, we construct the first real-world GS point cloud dataset in the community, which includes 20 categories with 200 objects in each category. Experiments not only validate the superiority of GS point cloud input, especially in distinguishing ambiguous objects, but also demonstrate the generalization ability across different classification methods.

The Multi-Trip Time-Dependent Mix Vehicle Routing Problem for Hybrid Autonomous Shared Delivery Location and Traditional Door-to-Door Delivery Modes

Rising labor costs and increasing logistical demands pose significant challenges to modern delivery systems. Automated Electric Vehicles (AEVs) could reduce reliance on delivery personnel and increase route flexibility, but their adoption is limited due to varying customer acceptance and integration complexities. Shared Distribution Locations (SDLs) offer an alternative to door-to-door (D2D) delivery by providing a wider delivery window and serving multiple community customers, thereby improving last-mile logistics through reduced delivery time, lower costs, and higher customer satisfaction.This paper introduces the Multi-Trip Time-Dependent Hybrid Vehicle Routing Problem (MTTD-MVRP), a challenging variant of the Vehicle Routing Problem (VRP) that combines Autonomous Electric Vehicles (AEVs) with conventional vehicles. The problem's complexity arises from factors such as time-dependent travel speeds, strict time windows, battery limitations, and driver labor constraints, while integrating both SDLs and D2D deliveries. To solve the MTTD-MVRP efficiently, we develop a tailored meta-heuristic based on Adaptive Large Neighborhood Search (ALNS) augmented with column generation (CG). This approach intensively explores the solution space using problem-specific operators and adaptively refines solutions, balancing high-quality outcomes with computational effort. Extensive experiments show that the proposed method delivers near-optimal solutions for large-scale instances within practical time limits.From a managerial perspective, our findings highlight the importance of integrating autonomous and human-driven vehicles in last-mile logistics. Decision-makers can leverage SDLs to reduce operational costs and carbon footprints while still accommodating customers who require or prefer D2D services.

A Deep Generative Model for the Design of Synthesizable Ionizable Lipids

Lipid nanoparticles (LNPs) are vital in modern biomedicine, enabling the effective delivery of mRNA for vaccines and therapies by protecting it from rapid degradation. Among the components of LNPs, ionizable lipids play a key role in RNA protection and facilitate its delivery into the cytoplasm. However, designing ionizable lipids is complex. Deep generative models can accelerate this process and explore a larger candidate space compared to traditional methods. Due to the structural differences between lipids and small molecules, existing generative models used for small molecule generation are unsuitable for lipid generation. To address this, we developed a deep generative model specifically tailored for the discovery of ionizable lipids. Our model generates novel ionizable lipid structures and provides synthesis paths using synthetically accessible building blocks, addressing synthesizability. This advancement holds promise for streamlining the development of lipid-based delivery systems, potentially accelerating the deployment of new therapeutic agents, including mRNA vaccines and gene therapies.

Generative Model for Synthesizing Ionizable Lipids: A Monte Carlo Tree Search Approach

Ionizable lipids are essential in developing lipid nanoparticles (LNPs) for effective messenger RNA (mRNA) delivery. While traditional methods for designing new ionizable lipids are typically time-consuming, deep generative models have emerged as a powerful solution, significantly accelerating the molecular discovery process. However, a practical challenge arises as the molecular structures generated can often be difficult or infeasible to synthesize. This project explores Monte Carlo tree search (MCTS)-based generative models for synthesizable ionizable lipids. Leveraging a synthetically accessible lipid building block dataset and two specialized predictors to guide the search through chemical space, we introduce a policy network guided MCTS generative model capable of producing new ionizable lipids with available synthesis pathways.

BFA-YOLO: Balanced multiscale object detection network for multi-view building facade attachments detection

Detection of building facade attachments such as doors, windows, balconies, air conditioner units, billboards, and glass curtain walls plays a pivotal role in numerous applications. Building facade attachments detection aids in vbuilding information modeling (BIM) construction and meeting Level of Detail 3 (LOD3) standards. Yet, it faces challenges like uneven object distribution, small object detection difficulty, and background interference. To counter these, we propose BFA-YOLO, a model for detecting facade attachments in multi-view images. BFA-YOLO incorporates three novel innovations: the Feature Balanced Spindle Module (FBSM) for addressing uneven distribution, the Target Dynamic Alignment Task Detection Head (TDATH) aimed at improving small object detection, and the Position Memory Enhanced Self-Attention Mechanism (PMESA) to combat background interference, with each component specifically designed to solve its corresponding challenge. Detection efficacy of deep network models deeply depends on the dataset's characteristics. Existing open source datasets related to building facades are limited by their single perspective, small image pool, and incomplete category coverage. We propose a novel method for building facade attachments detection dataset construction and construct the BFA-3D dataset for facade attachments detection. The BFA-3D dataset features multi-view, accurate labels, diverse categories, and detailed classification. BFA-YOLO surpasses YOLOv8 by 1.8% and 2.9% in mAP@0.5 on the multi-view BFA-3D and street-view Facade-WHU datasets, respectively. These results underscore BFA-YOLO's superior performance in detecting facade attachments.