Universal Abstraction: Harnessing Frontier Models to Structure Real-World Data at Scale

The vast majority of real-world patient information resides in unstructured clinical text, and the process of medical abstraction seeks to extract and normalize structured information from this unstructured input. However, traditional medical abstraction methods can require significant manual efforts that can include crafting rules or annotating training labels, limiting scalability. In this paper, we propose UniMedAbstractor (UMA), a zero-shot medical abstraction framework leveraging Large Language Models (LLMs) through a modular and customizable prompt template. We refer to our approach as universal abstraction as it can quickly scale to new attributes through its universal prompt template without curating attribute-specific training labels or rules. We evaluate UMA for oncology applications, focusing on fifteen key attributes representing the cancer patient journey, from short-context attributes (e.g., performance status, treatment) to complex long-context attributes requiring longitudinal reasoning (e.g., tumor site, histology, TNM staging). Experiments on real-world data show UMA's strong performance and generalizability. Compared to supervised and heuristic baselines, UMA with GPT-4o achieves on average an absolute 2-point F1/accuracy improvement for both short-context and long-context attribute abstraction. For pathologic T staging, UMA even outperforms the supervised model by 20 points in accuracy.

TRIALSCOPE: A Unifying Causal Framework for Scaling Real-World Evidence Generation with Biomedical Language Models

The rapid digitization of real-world data offers an unprecedented opportunity for optimizing healthcare delivery and accelerating biomedical discovery. In practice, however, such data is most abundantly available in unstructured forms, such as clinical notes in electronic medical records (EMRs), and it is generally plagued by confounders. In this paper, we present TRIALSCOPE, a unifying framework for distilling real-world evidence from population-level observational data. TRIALSCOPE leverages biomedical language models to structure clinical text at scale, employs advanced probabilistic modeling for denoising and imputation, and incorporates state-of-the-art causal inference techniques to combat common confounders. Using clinical trial specification as generic representation, TRIALSCOPE provides a turn-key solution to generate and reason with clinical hypotheses using observational data. In extensive experiments and analyses on a large-scale real-world dataset with over one million cancer patients from a large US healthcare network, we show that TRIALSCOPE can produce high-quality structuring of real-world data and generates comparable results to marquee cancer trials. In addition to facilitating in-silicon clinical trial design and optimization, TRIALSCOPE may be used to empower synthetic controls, pragmatic trials, post-market surveillance, as well as support fine-grained patient-like-me reasoning in precision diagnosis and treatment.