Tailoring Graph Neural Network-based Flow-guided Localization to Individual Bloodstreams and Activities

Flow-guided localization using in-body nanodevices in the bloodstream is expected to be beneficial for early disease detection, continuous monitoring of biological conditions, and targeted treatment. The nanodevices face size and power constraints that produce erroneous raw data for localization purposes. On-body anchors receive this data, and use it to derive the locations of diagnostic events of interest. Different Machine Learning (ML) approaches have been recently proposed for this task, yet they are currently restricted to a reference bloodstream of a resting patient. As such, they are unable to deal with the physical diversity of patients' bloodstreams and cannot provide continuous monitoring due to changes in individual patient's activities. Toward addressing these issues for the current State-of-the-Art (SotA) flow-guided localization approach based on Graph Neural Networks (GNNs), we propose a pipeline for GNN adaptation based on individual physiological indicators including height, weight, and heart rate. Our results indicate that the proposed adaptions are beneficial in reconciling the individual differences between bloodstreams and activities.

Multi-Gigabit Interactive Extended Reality over Millimeter-Wave: An End-to-End System Approach

Achieving high-quality wireless interactive Extended Reality (XR) will require multi-gigabit throughput at extremely low latency. The Millimeter-Wave (mmWave) frequency bands, between 24 and 300GHz, can achieve such extreme performance. However, maintaining a consistently high Quality of Experience with highly mobile users is challenging, as mmWave communications are inherently directional. In this work, we present and evaluate an end-to-end approach to such a mmWave-based mobile XR system. We perform a highly realistic simulation of the system, incorporating accurate XR data traffic, detailed mmWave propagation models and actual user motion. We evaluate the impact of the beamforming strategy and frequency on the overall performance. In addition, we provide the first system-level evaluation of the CoVRage algorithm, a proactive and spatially aware user-side beamforming approach designed specifically for highly mobile XR environments.

Analytical Modelling of Raw Data for Flow-Guided In-body Nanoscale Localization

Advancements in nanotechnology and material science are paving the way toward nanoscale devices that combine sensing, computing, data and energy storage, and wireless communication. In precision medicine, these nanodevices show promise for disease diagnostics, treatment, and monitoring from within the patients' bloodstreams. Assigning the location of a sensed biological event with the event itself, which is the main proposition of flow-guided in-body nanoscale localization, would be immensely beneficial from the perspective of precision medicine. The nanoscale nature of the nanodevices and the challenging environment that the bloodstream represents, result in current flow-guided localization approaches being constrained in their communication and energy-related capabilities. The communication and energy constraints of the nanodevices result in different features of raw data for flow-guided localization, in turn affecting its performance. An analytical modeling of the effects of imperfect communication and constrained energy causing intermittent operation of the nanodevices on the raw data produced by the nanodevices would be beneficial. Hence, we propose an analytical model of raw data for flow-guided localization, where the raw data is modeled as a function of communication and energy-related capabilities of the nanodevice. We evaluate the model by comparing its output with the one obtained through the utilization of a simulator for objective evaluation of flow-guided localization, featuring comparably higher level of realism. Our results across a number of scenarios and heterogeneous performance metrics indicate high similarity between the model and simulator-generated raw datasets.

Toward Energy Efficient Multiuser IRS-Assisted URLLC Systems: A Novel Rank Relaxation Method

This paper proposes an energy efficient resource allocation design algorithm for an intelligent reflecting surface (IRS)-assisted downlink ultra-reliable low-latency communication (URLLC) network. This setup features a multi-antenna base station (BS) transmitting data traffic to a group of URLLC users with short packet lengths. We maximize the total network's energy efficiency (EE) through the optimization of active beamformers at the BS and passive beamformers (a.k.a. phase shifts) at the IRS. The main non-convex problem is divided into two sub-problems. An alternating optimization (AO) approach is then used to solve the problem. Through the use of the successive convex approximation (SCA) with a novel iterative rank relaxation method, we construct a concave-convex objective function for each sub-problem. The first sub-problem is a fractional program that is solved using the Dinkelbach method and a penalty-based approach. The second sub-problem is then solved based on semi-definite programming (SDP) and the penalty-based approach. The iterative solution gradually approaches the rank-one for both the active beamforming and unit modulus IRS phase-shift sub-problems. Our results demonstrate the efficacy of the proposed solution compared to existing benchmarks.

Graph Neural Network-enabled Terahertz-based Flow-guided Nanoscale Localization

Scientific advancements in nanotechnology and advanced materials are paving the way toward nanoscale devices for in-body precision medicine; comprising integrated sensing, computing, communication, data and energy storage capabilities. In the human cardiovascular system, such devices are envisioned to be passively flowing and continuously sensing for detecting events of diagnostic interest. The diagnostic value of detecting such events can be enhanced by assigning to them their physical locations (e.g., body region), which is the main proposition of flow-guided localization. Current flow-guided localization approaches suffer from low localization accuracy and they are by-design unable to localize events within the entire cardiovascular system. Toward addressing this issue, we propose the utilization of Graph Neural Networks (GNNs) for this purpose, and demonstrate localization accuracy and coverage enhancements of our proposal over the existing State of the Art (SotA) approaches. Based on our evaluation, we provide several design guidelines for GNN-enabled flow-guided localization.

Insights from the Design Space Exploration of Flow-Guided Nanoscale Localization

Nanodevices with Terahertz (THz)-based wireless communication capabilities are providing a primer for flow-guided localization within the human bloodstreams. Such localization is allowing for assigning the locations of sensed events with the events themselves, providing benefits in precision medicine along the lines of early and precise diagnostics, and reduced costs and invasiveness. Flow-guided localization is still in a rudimentary phase, with only a handful of works targeting the problem. Nonetheless, the performance assessments of the proposed solutions are already carried out in a non-standardized way, usually along a single performance metric, and ignoring various aspects that are relevant at such a scale (e.g., nanodevices' limited energy) and for such a challenging environment (e.g., extreme attenuation of in-body THz propagation). As such, these assessments feature low levels of realism and cannot be compared in an objective way. Toward addressing this issue, we account for the environmental and scale-related peculiarities of the scenario and assess the performance of two state-of-the-art flow-guided localization approaches along a set of heterogeneous performance metrics such as the accuracy and reliability of localization.

Predictive Context-Awareness for Full-Immersive Multiuser Virtual Reality with Redirected Walking

The advancement of Virtual Reality (VR) technology is focused on improving its immersiveness, supporting multiuser Virtual Experiences (VEs), and enabling the users to move freely within their VEs while still being confined within specialized VR setups through Redirected Walking (RDW). To meet their extreme data-rate and latency requirements, future VR systems will require supporting wireless networking infrastructures operating in millimeter Wave (mmWave) frequencies that leverage highly directional communication in both transmission and reception through beamforming and beamsteering. We propose the use of predictive context-awareness to optimize transmitter and receiver-side beamforming and beamsteering. By predicting users' short-term lateral movements in multiuser VR setups with Redirected Walking (RDW), transmitter-side beamforming and beamsteering can be optimized through Line-of-Sight (LoS) "tracking" in the users' directions. At the same time, predictions of short-term orientational movements can be utilized for receiver-side beamforming for coverage flexibility enhancements. We target two open problems in predicting these two context information instances: i) predicting lateral movements in multiuser VR settings with RDW, and ii) generating synthetic head rotation datasets for training orientational movements predictors. Our experimental results demonstrate that Long Short-Term Memory (LSTM) networks feature promising accuracy in predicting lateral movements, and context-awareness stemming from VEs further enhances this accuracy. Additionally, we show that a TimeGAN-based approach for orientational data generation can create synthetic samples that closely match experimentally obtained ones.

CoVRage: Millimeter-Wave Beamforming for Mobile Interactive Virtual Reality

Contemporary Virtual Reality (VR) setups often include an external source delivering content to a Head-Mounted Display (HMD). "Cutting the wire" in such setups and going truly wireless will require a wireless network capable of delivering enormous amounts of video data at an extremely low latency. The massive bandwidth of higher frequencies, such as the millimeter-wave (mmWave) band, can meet these requirements. Due to high attenuation and path loss in the mmWave frequencies, beamforming is essential. In wireless VR, where the antenna is integrated into the HMD, any head rotation also changes the antenna's orientation. As such, beamforming must adapt, in real-time, to the user's head rotations. An HMD's built-in sensors providing accurate orientation estimates may facilitate such rapid beamforming. In this work, we present coVRage, a receive-side beamforming solution tailored for VR HMDs. Using built-in orientation prediction present on modern HMDs, the algorithm estimates how the Angle of Arrival (AoA) at the HMD will change in the near future, and covers this AoA trajectory with a dynamically shaped oblong beam, synthesized using sub-arrays. We show that this solution can cover these trajectories with consistently high gain, even in light of temporally or spatially inaccurate orientational data.

Short-Term Trajectory Prediction for Full-Immersive Multiuser Virtual Reality with Redirected Walking

Full-immersive multiuser Virtual Reality (VR) envisions supporting unconstrained mobility of the users in the virtual worlds, while at the same time constraining their physical movements inside VR setups through redirected walking. For enabling delivery of high data rate video content in real-time, the supporting wireless networks will leverage highly directional communication links that will "track" the users for maintaining the Line-of-Sight (LoS) connectivity. Recurrent Neural Networks (RNNs) and in particular Long Short-Term Memory (LSTM) networks have historically presented themselves as a suitable candidate for near-term movement trajectory prediction for natural human mobility, and have also recently been shown as applicable in predicting VR users' mobility under the constraints of redirected walking. In this work, we extend these initial findings by showing that Gated Recurrent Unit (GRU) networks, another candidate from the RNN family, generally outperform the traditionally utilized LSTMs. Second, we show that context from a virtual world can enhance the accuracy of the prediction if used as an additional input feature in comparison to the more traditional utilization of solely the historical physical movements of the VR users. Finally, we show that the prediction system trained on a static number of coexisting VR users be scaled to a multi-user system without significant accuracy degradation.

Intelligent Reflective Surface vs. Mobile Relay-supported NLoS Avoidance in Indoor mmWave Networks

The 6th generation of wireless communication (6G) is envisioned to give rise to various technologies for improving the end-to-end communication performance, where the communication is envisioned to utilize wireless signals in the millimeter wave (mmWave) frequencies and above. Among others, these technologies comprise Intelligent Reflective Surfaces (IRSs) and Mobile Relays (MRs), whose envisaged roles include mitigating the negative effects of Non-Line-of-Sight (NLoS) connectivity, in particular at mmWave and higher frequencies. The core idea behind these technologies is to use cooperative networking where the source sends a signal to a repeater, in this case the IRS or the MR, which is upon reception forwarded to the destination. When comparing the two technologies, it is important to realize that the IRSs are primarily envisioned to be static entities attached to various objects in the environment such as walls and furniture. In contrast, the MRs will feature a higher degree of freedom, as they will be able to position themselves seamlessly in the environment. Based on the above assumptions, we derive an approach for determining the optimal position of the IRS and MR in indoor environments, i.e., the one that maximizes the end-to-end link quality between the source and the destination. We follow by capturing the communication quality indicators for both IRS- and MR-supported NLoS avoidance in indoor mmWave communication in a number of scenarios. Our results show that, from the end-to-end link quality perspective, the MRs generally outperform the IRSs, suggesting their utilization potential for throughput-optimized NLoS avoidance scenarios.