MMR-Mamba: Multi-Modal MRI Reconstruction with Mamba and Spatial-Frequency Information Fusion

Multi-modal MRI offers valuable complementary information for diagnosis and treatment; however, its utility is limited by prolonged scanning times. To accelerate the acquisition process, a practical approach is to reconstruct images of the target modality, which requires longer scanning times, from under-sampled k-space data using the fully-sampled reference modality with shorter scanning times as guidance. The primary challenge of this task is comprehensively and efficiently integrating complementary information from different modalities to achieve high-quality reconstruction. Existing methods struggle with this: 1) convolution-based models fail to capture long-range dependencies; 2) transformer-based models, while excelling in global feature modeling, struggle with quadratic computational complexity. To address this, we propose MMR-Mamba, a novel framework that thoroughly and efficiently integrates multi-modal features for MRI reconstruction, leveraging Mamba's capability to capture long-range dependencies with linear computational complexity while exploiting global properties of the Fourier domain. Specifically, we first design a Target modality-guided Cross Mamba (TCM) module in the spatial domain, which maximally restores the target modality information by selectively incorporating relevant information from the reference modality. Then, we introduce a Selective Frequency Fusion (SFF) module to efficiently integrate global information in the Fourier domain and recover high-frequency signals for the reconstruction of structural details. Furthermore, we devise an Adaptive Spatial-Frequency Fusion (ASFF) module, which mutually enhances the spatial and frequency domains by supplementing less informative channels from one domain with corresponding channels from the other.

Synthesizing PET images from High-field and Ultra-high-field MR images Using Joint Diffusion Attention Model

MRI and PET are crucial diagnostic tools for brain diseases, as they provide complementary information on brain structure and function. However, PET scanning is costly and involves radioactive exposure, resulting in a lack of PET. Moreover, simultaneous PET and MRI at ultra-high-field are currently hardly infeasible. Ultra-high-field imaging has unquestionably proven valuable in both clinical and academic settings, especially in the field of cognitive neuroimaging. These motivate us to propose a method for synthetic PET from high-filed MRI and ultra-high-field MRI. From a statistical perspective, the joint probability distribution (JPD) is the most direct and fundamental means of portraying the correlation between PET and MRI. This paper proposes a novel joint diffusion attention model which has the joint probability distribution and attention strategy, named JDAM. JDAM has a diffusion process and a sampling process. The diffusion process involves the gradual diffusion of PET to Gaussian noise by adding Gaussian noise, while MRI remains fixed. JPD of MRI and noise-added PET was learned in the diffusion process. The sampling process is a predictor-corrector. PET images were generated from MRI by JPD of MRI and noise-added PET. The predictor is a reverse diffusion process and the corrector is Langevin dynamics. Experimental results on the public Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset demonstrate that the proposed method outperforms state-of-the-art CycleGAN for high-field MRI (3T MRI). Finally, synthetic PET images from the ultra-high-field (5T MRI and 7T MRI) be attempted, providing a possibility for ultra-high-field PET-MRI imaging.

Total-Body Low-Dose CT Image Denoising using Prior Knowledge Transfer Technique with Contrastive Regularization Mechanism

Reducing the radiation exposure for patients in Total-body CT scans has attracted extensive attention in the medical imaging community. Given the fact that low radiation dose may result in increased noise and artifacts, which greatly affected the clinical diagnosis. To obtain high-quality Total-body Low-dose CT (LDCT) images, previous deep-learning-based research work has introduced various network architectures. However, most of these methods only adopt Normal-dose CT (NDCT) images as ground truths to guide the training of the denoising network. Such simple restriction leads the model to less effectiveness and makes the reconstructed images suffer from over-smoothing effects. In this paper, we propose a novel intra-task knowledge transfer method that leverages the distilled knowledge from NDCT images to assist the training process on LDCT images. The derived architecture is referred to as the Teacher-Student Consistency Network (TSC-Net), which consists of the teacher network and the student network with identical architecture. Through the supervision between intermediate features, the student network is encouraged to imitate the teacher network and gain abundant texture details. Moreover, to further exploit the information contained in CT scans, a contrastive regularization mechanism (CRM) built upon contrastive learning is introduced.CRM performs to pull the restored CT images closer to the NDCT samples and push far away from the LDCT samples in the latent space. In addition, based on the attention and deformable convolution mechanism, we design a Dynamic Enhancement Module (DEM) to improve the network transformation capability.