MAM: Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis via Role-Specialized Collaboration

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs, comprehensiveness, and flexibility. To address these challenges, we introduce the Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis (MAM). Inspired by our empirical findings highlighting the benefits of role assignment and diagnostic discernment in LLMs, MAM decomposes the medical diagnostic process into specialized roles: a General Practitioner, Specialist Team, Radiologist, Medical Assistant, and Director, each embodied by an LLM-based agent. This modular and collaborative framework enables efficient knowledge updates and leverages existing medical LLMs and knowledge bases. Extensive experimental evaluations conducted on a wide range of publicly accessible multimodal medical datasets, incorporating text, image, audio, and video modalities, demonstrate that MAM consistently surpasses the performance of modality-specific LLMs. Notably, MAM achieves significant performance improvements ranging from 18% to 365% compared to baseline models. Our code is released at https://github.com/yczhou001/MAM.

ComplexBench-Edit: Benchmarking Complex Instruction-Driven Image Editing via Compositional Dependencies

Text-driven image editing has achieved remarkable success in following single instructions. However, real-world scenarios often involve complex, multi-step instructions, particularly ``chain'' instructions where operations are interdependent. Current models struggle with these intricate directives, and existing benchmarks inadequately evaluate such capabilities. Specifically, they often overlook multi-instruction and chain-instruction complexities, and common consistency metrics are flawed. To address this, we introduce ComplexBench-Edit, a novel benchmark designed to systematically assess model performance on complex, multi-instruction, and chain-dependent image editing tasks. ComplexBench-Edit also features a new vision consistency evaluation method that accurately assesses non-modified regions by excluding edited areas. Furthermore, we propose a simple yet powerful Chain-of-Thought (CoT)-based approach that significantly enhances the ability of existing models to follow complex instructions. Our extensive experiments demonstrate ComplexBench-Edit's efficacy in differentiating model capabilities and highlight the superior performance of our CoT-based method in handling complex edits. The data and code are released at https://github.com/llllly26/ComplexBench-Edit.

Draw ALL Your Imagine: A Holistic Benchmark and Agent Framework for Complex Instruction-based Image Generation

Recent advancements in text-to-image (T2I) generation have enabled models to produce high-quality images from textual descriptions. However, these models often struggle with complex instructions involving multiple objects, attributes, and spatial relationships. Existing benchmarks for evaluating T2I models primarily focus on general text-image alignment and fail to capture the nuanced requirements of complex, multi-faceted prompts. Given this gap, we introduce LongBench-T2I, a comprehensive benchmark specifically designed to evaluate T2I models under complex instructions. LongBench-T2I consists of 500 intricately designed prompts spanning nine diverse visual evaluation dimensions, enabling a thorough assessment of a model's ability to follow complex instructions. Beyond benchmarking, we propose an agent framework (Plan2Gen) that facilitates complex instruction-driven image generation without requiring additional model training. This framework integrates seamlessly with existing T2I models, using large language models to interpret and decompose complex prompts, thereby guiding the generation process more effectively. As existing evaluation metrics, such as CLIPScore, fail to adequately capture the nuances of complex instructions, we introduce an evaluation toolkit that automates the quality assessment of generated images using a set of multi-dimensional metrics. The data and code are released at https://github.com/yczhou001/LongBench-T2I.

Safety Alignment via Constrained Knowledge Unlearning

Despite significant progress in safety alignment, large language models (LLMs) remain susceptible to jailbreak attacks. Existing defense mechanisms have not fully deleted harmful knowledge in LLMs, which allows such attacks to bypass safeguards and produce harmful outputs. To address this challenge, we propose a novel safety alignment strategy, Constrained Knowledge Unlearning (CKU), which focuses on two primary objectives: knowledge localization and retention, and unlearning harmful knowledge. CKU works by scoring neurons in specific multilayer perceptron (MLP) layers to identify a subset U of neurons associated with useful knowledge. During the unlearning process, CKU prunes the gradients of neurons in U to preserve valuable knowledge while effectively mitigating harmful content. Experimental results demonstrate that CKU significantly enhances model safety without compromising overall performance, offering a superior balance between safety and utility compared to existing methods. Additionally, our analysis of neuron knowledge sensitivity across various MLP layers provides valuable insights into the mechanics of safety alignment and model knowledge editing.

Self-Rewarding Large Vision-Language Models for Optimizing Prompts in Text-to-Image Generation

Text-to-image models are powerful for producing high-quality images based on given text prompts, but crafting these prompts often requires specialized vocabulary. To address this, existing methods train rewriting models with supervision from large amounts of manually annotated data and trained aesthetic assessment models. To alleviate the dependence on data scale for model training and the biases introduced by trained models, we propose a novel prompt optimization framework, designed to rephrase a simple user prompt into a sophisticated prompt to a text-to-image model. Specifically, we employ the large vision language models (LVLMs) as the solver to rewrite the user prompt, and concurrently, employ LVLMs as a reward model to score the aesthetics and alignment of the images generated by the optimized prompt. Instead of laborious human feedback, we exploit the prior knowledge of the LVLM to provide rewards, i.e., AI feedback. Simultaneously, the solver and the reward model are unified into one model and iterated in reinforcement learning to achieve self-improvement by giving a solution and judging itself. Results on two popular datasets demonstrate that our method outperforms other strong competitors.

Beyond Empathy: Integrating Diagnostic and Therapeutic Reasoning with Large Language Models for Mental Health Counseling

Large language models (LLMs) hold significant potential for mental health support, capable of generating empathetic responses and simulating therapeutic conversations. However, existing LLM-based approaches often lack the clinical grounding necessary for real-world psychological counseling, particularly in explicit diagnostic reasoning aligned with standards like the DSM/ICD and incorporating diverse therapeutic modalities beyond basic empathy or single strategies. To address these critical limitations, we propose PsyLLM, the first large language model designed to systematically integrate both diagnostic and therapeutic reasoning for mental health counseling. To develop the PsyLLM, we propose a novel automated data synthesis pipeline. This pipeline processes real-world mental health posts, generates multi-turn dialogue structures, and leverages LLMs guided by international diagnostic standards (e.g., DSM/ICD) and multiple therapeutic frameworks (e.g., CBT, ACT, psychodynamic) to simulate detailed clinical reasoning processes. Rigorous multi-dimensional filtering ensures the generation of high-quality, clinically aligned dialogue data. In addition, we introduce a new benchmark and evaluation protocol, assessing counseling quality across four key dimensions: comprehensiveness, professionalism, authenticity, and safety. Our experiments demonstrate that PsyLLM significantly outperforms state-of-the-art baseline models on this benchmark.

DC-ControlNet: Decoupling Inter- and Intra-Element Conditions in Image Generation with Diffusion Models

In this paper, we introduce DC (Decouple)-ControlNet, a highly flexible and precisely controllable framework for multi-condition image generation. The core idea behind DC-ControlNet is to decouple control conditions, transforming global control into a hierarchical system that integrates distinct elements, contents, and layouts. This enables users to mix these individual conditions with greater flexibility, leading to more efficient and accurate image generation control. Previous ControlNet-based models rely solely on global conditions, which affect the entire image and lack the ability of element- or region-specific control. This limitation reduces flexibility and can cause condition misunderstandings in multi-conditional image generation. To address these challenges, we propose both intra-element and Inter-element Controllers in DC-ControlNet. The Intra-Element Controller handles different types of control signals within individual elements, accurately describing the content and layout characteristics of the object. For interactions between elements, we introduce the Inter-Element Controller, which accurately handles multi-element interactions and occlusion based on user-defined relationships. Extensive evaluations show that DC-ControlNet significantly outperforms existing ControlNet models and Layout-to-Image generative models in terms of control flexibility and precision in multi-condition control.

EmoBench-M: Benchmarking Emotional Intelligence for Multimodal Large Language Models

With the integration of Multimodal large language models (MLLMs) into robotic systems and various AI applications, embedding emotional intelligence (EI) capabilities into these models is essential for enabling robots to effectively address human emotional needs and interact seamlessly in real-world scenarios. Existing static, text-based, or text-image benchmarks overlook the multimodal complexities of real-world interactions and fail to capture the dynamic, multimodal nature of emotional expressions, making them inadequate for evaluating MLLMs' EI. Based on established psychological theories of EI, we build EmoBench-M, a novel benchmark designed to evaluate the EI capability of MLLMs across 13 valuation scenarios from three key dimensions: foundational emotion recognition, conversational emotion understanding, and socially complex emotion analysis. Evaluations of both open-source and closed-source MLLMs on EmoBench-M reveal a significant performance gap between them and humans, highlighting the need to further advance their EI capabilities. All benchmark resources, including code and datasets, are publicly available at https://emo-gml.github.io/.

Training Medical Large Vision-Language Models with Abnormal-Aware Feedback

Existing Medical Large Vision-Language Models (Med-LVLMs), which encapsulate extensive medical knowledge, demonstrate excellent capabilities in understanding medical images and responding to human queries based on these images. However, there remain challenges in visual localization in medical images, which is crucial for abnormality detection and interpretation. To address these issues, we propose a novel UMed-LVLM designed with Unveiling Medical abnormalities. Specifically, we collect a Medical Abnormalities Unveiling (MAU) dataset and propose a two-stage training method for UMed-LVLM training. To collect MAU dataset, we propose a prompt method utilizing the GPT-4V to generate diagnoses based on identified abnormal areas in medical images. Moreover, the two-stage training method includes Abnormal-Aware Instruction Tuning and Abnormal-Aware Rewarding, comprising Abnormal Localization Rewarding and Vision Relevance Rewarding. Experimental results demonstrate that our UMed-LVLM surpasses existing Med-LVLMs in identifying and understanding medical abnormality. In addition, this work shows that enhancing the abnormality detection capabilities of Med-LVLMs significantly improves their understanding of medical images and generalization capability.

Diffusion Model with Representation Alignment for Protein Inverse Folding

Protein inverse folding is a fundamental problem in bioinformatics, aiming to recover the amino acid sequences from a given protein backbone structure. Despite the success of existing methods, they struggle to fully capture the intricate inter-residue relationships critical for accurate sequence prediction. We propose a novel method that leverages diffusion models with representation alignment (DMRA), which enhances diffusion-based inverse folding by (1) proposing a shared center that aggregates contextual information from the entire protein structure and selectively distributes it to each residue; and (2) aligning noisy hidden representations with clean semantic representations during the denoising process. This is achieved by predefined semantic representations for amino acid types and a representation alignment method that utilizes type embeddings as semantic feedback to normalize each residue. In experiments, we conduct extensive evaluations on the CATH4.2 dataset to demonstrate that DMRA outperforms leading methods, achieving state-of-the-art performance and exhibiting strong generalization capabilities on the TS50 and TS500 datasets.