Open Challenges and Opportunities in Federated Foundation Models Towards Biomedical Healthcare

This survey explores the transformative impact of foundation models (FMs) in artificial intelligence, focusing on their integration with federated learning (FL) for advancing biomedical research. Foundation models such as ChatGPT, LLaMa, and CLIP, which are trained on vast datasets through methods including unsupervised pretraining, self-supervised learning, instructed fine-tuning, and reinforcement learning from human feedback, represent significant advancements in machine learning. These models, with their ability to generate coherent text and realistic images, are crucial for biomedical applications that require processing diverse data forms such as clinical reports, diagnostic images, and multimodal patient interactions. The incorporation of FL with these sophisticated models presents a promising strategy to harness their analytical power while safeguarding the privacy of sensitive medical data. This approach not only enhances the capabilities of FMs in medical diagnostics and personalized treatment but also addresses critical concerns about data privacy and security in healthcare. This survey reviews the current applications of FMs in federated settings, underscores the challenges, and identifies future research directions including scaling FMs, managing data diversity, and enhancing communication efficiency within FL frameworks. The objective is to encourage further research into the combined potential of FMs and FL, laying the groundwork for groundbreaking healthcare innovations.

Adaptive Transfer Learning of Multi-View Time Series Classification

Time Series Classification (TSC) has been an important and challenging task in data mining, especially on multivariate time series and multi-view time series data sets. Meanwhile, transfer learning has been widely applied in computer vision and natural language processing applications to improve deep neural network's generalization capabilities. However, very few previous works applied transfer learning framework to time series mining problems. Particularly, the technique of measuring similarities between source domain and target domain based on dynamic representation such as density estimation with importance sampling has never been combined with transfer learning framework. In this paper, we first proposed a general adaptive transfer learning framework for multi-view time series data, which shows strong ability in storing inter-view importance value in the process of knowledge transfer. Next, we represented inter-view importance through some time series similarity measurements and approximated the posterior distribution in latent space for the importance sampling via density estimation techniques. We then computed the matrix norm of sampled importance value, which controls the degree of knowledge transfer in pre-training process. We further evaluated our work, applied it to many other time series classification tasks, and observed that our architecture maintained desirable generalization ability. Finally, we concluded that our framework could be adapted with deep learning techniques to receive significant model performance improvements.

LEARN: Learned Experts' Assessment-based Reconstruction Network for Sparse-data CT

Compressive sensing (CS) has proved effective for tomographic reconstruction from sparsely collected data or under-sampled measurements, which are practically important for few-view CT, tomosynthesis, interior tomography, and so on. To perform sparse-data CT, the iterative reconstruction commonly use regularizers in the CS framework. Currently, how to choose the parameters adaptively for regularization is a major open problem. In this paper, inspired by the idea of machine learning especially deep learning, we unfold a state-of-the-art "fields of experts" based iterative reconstruction scheme up to a number of iterations for data-driven training, construct a Learned Experts' Assessment-based Reconstruction Network ("LEARN") for sparse-data CT, and demonstrate the feasibility and merits of our LEARN network. The experimental results with our proposed LEARN network produces a competitive performance with the well-known Mayo Clinic Low-Dose Challenge Dataset relative to several state-of-the-art methods, in terms of artifact reduction, feature preservation, and computational speed. This is consistent to our insight that because all the regularization terms and parameters used in the iterative reconstruction are now learned from the training data, our LEARN network utilizes application-oriented knowledge more effectively and recovers underlying images more favorably than competing algorithms. Also, the number of layers in the LEARN network is only 12, reducing the computational complexity of typical iterative algorithms by orders of magnitude.

Low-dose CT denoising with convolutional neural network

To reduce the potential radiation risk, low-dose CT has attracted much attention. However, simply lowering the radiation dose will lead to significant deterioration of the image quality. In this paper, we propose a noise reduction method for low-dose CT via deep neural network without accessing original projection data. A deep convolutional neural network is trained to transform low-dose CT images towards normal-dose CT images, patch by patch. Visual and quantitative evaluation demonstrates a competing performance of the proposed method.