Let Curves Speak: A Continuous Glucose Monitor based Large Sensor Foundation Model for Diabetes Management

While previous studies of AI in diabetes management focus on long-term risk, research on near-future glucose prediction remains limited but important as it enables timely diabetes self-management. Integrating AI with continuous glucose monitoring (CGM) holds promise for near-future glucose prediction. However, existing models have limitations in capturing patterns of blood glucose fluctuations and demonstrate poor generalizability. A robust approach is needed to leverage massive CGM data for near-future glucose prediction. We propose large sensor models (LSMs) to capture knowledge in CGM data by modeling patients as sequences of glucose. CGM-LSM is pretrained on 15.96 million glucose records from 592 diabetes patients for near-future glucose prediction. We evaluated CGM-LSM against state-of-the-art methods using the OhioT1DM dataset across various metrics, prediction horizons, and unseen patients. Additionally, we assessed its generalizability across factors like diabetes type, age, gender, and hour of day. CGM-LSM achieved exceptional performance, with an rMSE of 29.81 mg/dL for type 1 diabetes patients and 23.49 mg/dL for type 2 diabetes patients in a two-hour prediction horizon. For the OhioT1DM dataset, CGM-LSM achieved a one-hour rMSE of 15.64 mg/dL, halving the previous best of 31.97 mg/dL. Robustness analyses revealed consistent performance not only for unseen patients and future periods, but also across diabetes type, age, and gender. The model demonstrated adaptability to different hours of day, maintaining accuracy across periods of various activity intensity levels. CGM-LSM represents a transformative step in diabetes management by leveraging pretraining to uncover latent glucose generation patterns in sensor data. Our findings also underscore the broader potential of LSMs to drive innovation across domains involving complex sensor data.

People Talking and AI Listening: How Stigmatizing Language in EHR Notes Affect AI Performance

Electronic health records (EHRs) serve as an essential data source for the envisioned artificial intelligence (AI)-driven transformation in healthcare. However, clinician biases reflected in EHR notes can lead to AI models inheriting and amplifying these biases, perpetuating health disparities. This study investigates the impact of stigmatizing language (SL) in EHR notes on mortality prediction using a Transformer-based deep learning model and explainable AI (XAI) techniques. Our findings demonstrate that SL written by clinicians adversely affects AI performance, particularly so for black patients, highlighting SL as a source of racial disparity in AI model development. To explore an operationally efficient way to mitigate SL's impact, we investigate patterns in the generation of SL through a clinicians' collaborative network, identifying central clinicians as having a stronger impact on racial disparity in the AI model. We find that removing SL written by central clinicians is a more efficient bias reduction strategy than eliminating all SL in the entire corpus of data. This study provides actionable insights for responsible AI development and contributes to understanding clinician behavior and EHR note writing in healthcare.

Catch Me If You Can: Identifying Fraudulent Physician Reviews with Large Language Models Using Generative Pre-Trained Transformers

The proliferation of fake reviews of doctors has potentially detrimental consequences for patient well-being and has prompted concern among consumer protection groups and regulatory bodies. Yet despite significant advancements in the fields of machine learning and natural language processing, there remains limited comprehension of the characteristics differentiating fraudulent from authentic reviews. This study utilizes a novel pre-labeled dataset of 38048 physician reviews to establish the effectiveness of large language models in classifying reviews. Specifically, we compare the performance of traditional ML models, such as logistic regression and support vector machines, to generative pre-trained transformer models. Furthermore, we use GPT4, the newest model in the GPT family, to uncover the key dimensions along which fake and genuine physician reviews differ. Our findings reveal significantly superior performance of GPT-3 over traditional ML models in this context. Additionally, our analysis suggests that GPT3 requires a smaller training sample than traditional models, suggesting its appropriateness for tasks with scarce training data. Moreover, the superiority of GPT3 performance increases in the cold start context i.e., when there are no prior reviews of a doctor. Finally, we employ GPT4 to reveal the crucial dimensions that distinguish fake physician reviews. In sharp contrast to previous findings in the literature that were obtained using simulated data, our findings from a real-world dataset show that fake reviews are generally more clinically detailed, more reserved in sentiment, and have better structure and grammar than authentic ones.

Finding patterns in Knowledge Attribution for Transformers

We analyze the Knowledge Neurons framework for the attribution of factual and relational knowledge to particular neurons in the transformer network. We use a 12-layer multi-lingual BERT model for our experiments. Our study reveals various interesting phenomena. We observe that mostly factual knowledge can be attributed to middle and higher layers of the network($\ge 6$). Further analysis reveals that the middle layers($6-9$) are mostly responsible for relational information, which is further refined into actual factual knowledge or the "correct answer" in the last few layers($10-12$). Our experiments also show that the model handles prompts in different languages, but representing the same fact, similarly, providing further evidence for effectiveness of multi-lingual pre-training. Applying the attribution scheme for grammatical knowledge, we find that grammatical knowledge is far more dispersed among the neurons than factual knowledge.