Multi-Intent Attribute-Aware Text Matching in Searching

Text matching systems have become a fundamental service in most searching platforms. For instance, they are responsible for matching user queries to relevant candidate items, or rewriting the user-input query to a pre-selected high-performing one for a better search experience. In practice, both the queries and items often contain multiple attributes, such as the category of the item and the location mentioned in the query, which represent condensed key information that is helpful for matching. However, most of the existing works downplay the effectiveness of attributes by integrating them into text representations as supplementary information. Hence, in this work, we focus on exploring the relationship between the attributes from two sides. Since attributes from two ends are often not aligned in terms of number and type, we propose to exploit the benefit of attributes by multiple-intent modeling. The intents extracted from attributes summarize the diverse needs of queries and provide rich content of items, which are more refined and abstract, and can be aligned for paired inputs. Concretely, we propose a multi-intent attribute-aware matching model (MIM), which consists of three main components: attribute-aware encoder, multi-intent modeling, and intent-aware matching. In the attribute-aware encoder, the text and attributes are weighted and processed through a scaled attention mechanism with regard to the attributes' importance. Afterward, the multi-intent modeling extracts intents from two ends and aligns them. Herein, we come up with a distribution loss to ensure the learned intents are diverse but concentrated, and a kullback-leibler divergence loss that aligns the learned intents. Finally, in the intent-aware matching, the intents are evaluated by a self-supervised masking task, and then incorporated to output the final matching result.

A powerful and efficient set test for genetic markers that handles confounders

Approaches for testing sets of variants, such as a set of rare or common variants within a gene or pathway, for association with complex traits are important. In particular, set tests allow for aggregation of weak signal within a set, can capture interplay among variants, and reduce the burden of multiple hypothesis testing. Until now, these approaches did not address confounding by family relatedness and population structure, a problem that is becoming more important as larger data sets are used to increase power. Results: We introduce a new approach for set tests that handles confounders. Our model is based on the linear mixed model and uses two random effects-one to capture the set association signal and one to capture confounders. We also introduce a computational speedup for two-random-effects models that makes this approach feasible even for extremely large cohorts. Using this model with both the likelihood ratio test and score test, we find that the former yields more power while controlling type I error. Application of our approach to richly structured GAW14 data demonstrates that our method successfully corrects for population structure and family relatedness, while application of our method to a 15,000 individual Crohn's disease case-control cohort demonstrates that it additionally recovers genes not recoverable by univariate analysis. Availability: A Python-based library implementing our approach is available at http://mscompbio.codeplex.com