Lifestyle-Informed Personalized Blood Biomarker Prediction via Novel Representation Learning

Blood biomarkers are an essential tool for healthcare providers to diagnose, monitor, and treat a wide range of medical conditions. Current reference values and recommended ranges often rely on population-level statistics, which may not adequately account for the influence of inter-individual variability driven by factors such as lifestyle and genetics. In this work, we introduce a novel framework for predicting future blood biomarker values and define personalized references through learned representations from lifestyle data (physical activity and sleep) and blood biomarkers. Our proposed method learns a similarity-based embedding space that captures the complex relationship between biomarkers and lifestyle factors. Using the UK Biobank (257K participants), our results show that our deep-learned embeddings outperform traditional and current state-of-the-art representation learning techniques in predicting clinical diagnosis. Using a subset of UK Biobank of 6440 participants who have follow-up visits, we validate that the inclusion of these embeddings and lifestyle factors directly in blood biomarker models improves the prediction of future lab values from a single lab visit. This personalized modeling approach provides a foundation for developing more accurate risk stratification tools and tailoring preventative care strategies. In clinical settings, this translates to the potential for earlier disease detection, more timely interventions, and ultimately, a shift towards personalized healthcare.

Learning Personal Food Preferences via Food Logs Embedding

Diet management is key to managing chronic diseases such as diabetes. Automated food recommender systems may be able to assist by providing meal recommendations that conform to a user's nutrition goals and food preferences. Current recommendation systems suffer from a lack of accuracy that is in part due to a lack of knowledge of food preferences, namely foods users like to and are able to eat frequently. In this work, we propose a method for learning food preferences from food logs, a comprehensive but noisy source of information about users' dietary habits. We also introduce accompanying metrics. The method generates and compares word embeddings to identify the parent food category of each food entry and then calculates the most popular. Our proposed approach identifies 82% of a user's ten most frequently eaten foods. Our method is publicly available on (https://github.com/aametwally/LearningFoodPreferences)