VCBench: A Streaming Counting Benchmark for Spatial-Temporal State Maintenance in Long Videos

Video understanding requires models to continuously track and update world state during playback. While existing benchmarks have advanced video understanding evaluation across multiple dimensions, the observation of how models maintain world state remains insufficient. We propose VCBench, a streaming counting benchmark that repositions counting as a minimal probe for diagnosing world state maintenance capability. We decompose this capability into object counting (tracking currently visible objects vs.\ tracking cumulative unique identities) and event counting (detecting instantaneous actions vs.\ tracking complete activity cycles), forming 8 fine-grained subcategories. VCBench contains 406 videos with frame-by-frame annotations of 10,071 event occurrence moments and object state change moments, generating 1,000 streaming QA pairs with 4,576 query points along timelines. By observing state maintenance trajectories through streaming multi-point queries, we design three complementary metrics to diagnose numerical precision, trajectory consistency, and temporal awareness. Evaluation on mainstream video-language models shows that current models still exhibit significant deficiencies in spatial-temporal state maintenance, particularly struggling with tasks like periodic event counting. VCBench provides a diagnostic framework for measuring and improving state maintenance in video understanding systems.

Breast Cancer Immunohistochemical Image Generation: a Benchmark Dataset and Challenge Review

For invasive breast cancer, immunohistochemical (IHC) techniques are often used to detect the expression level of human epidermal growth factor receptor-2 (HER2) in breast tissue to formulate a precise treatment plan. From the perspective of saving manpower, material and time costs, directly generating IHC-stained images from hematoxylin and eosin (H&E) stained images is a valuable research direction. Therefore, we held the breast cancer immunohistochemical image generation challenge, aiming to explore novel ideas of deep learning technology in pathological image generation and promote research in this field. The challenge provided registered H&E and IHC-stained image pairs, and participants were required to use these images to train a model that can directly generate IHC-stained images from corresponding H&E-stained images. We selected and reviewed the five highest-ranking methods based on their PSNR and SSIM metrics, while also providing overviews of the corresponding pipelines and implementations. In this paper, we further analyze the current limitations in the field of breast cancer immunohistochemical image generation and forecast the future development of this field. We hope that the released dataset and the challenge will inspire more scholars to jointly study higher-quality IHC-stained image generation.

BCI: Breast Cancer Immunohistochemical Image Generation through Pyramid Pix2pix

The evaluation of human epidermal growth factor receptor 2 (HER2) expression is essential to formulate a precise treatment for breast cancer. The routine evaluation of HER2 is conducted with immunohistochemical techniques (IHC), which is very expensive. Therefore, for the first time, we propose a breast cancer immunohistochemical (BCI) benchmark attempting to synthesize IHC data directly with the paired hematoxylin and eosin (HE) stained images. The dataset contains 4870 registered image pairs, covering a variety of HER2 expression levels. Based on BCI, as a minor contribution, we further build a pyramid pix2pix image generation method, which achieves better HE to IHC translation results than the other current popular algorithms. Extensive experiments demonstrate that BCI poses new challenges to the existing image translation research. Besides, BCI also opens the door for future pathology studies in HER2 expression evaluation based on the synthesized IHC images. BCI dataset can be downloaded from https://bupt-ai-cz.github.io/BCI.

Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides

Objectives: To develop and validate a deep learning (DL)-based primary tumor biopsy signature for predicting axillary lymph node (ALN) metastasis preoperatively in early breast cancer (EBC) patients with clinically negative ALN. Methods: A total of 1,058 EBC patients with pathologically confirmed ALN status were enrolled from May 2010 to August 2020. A DL core-needle biopsy (DL-CNB) model was built on the attention-based multiple instance-learning (AMIL) framework to predict ALN status utilizing the DL features, which were extracted from the cancer areas of digitized whole-slide images (WSIs) of breast CNB specimens annotated by two pathologists. Accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curves, and areas under the ROC curve (AUCs) were analyzed to evaluate our model. Results: The best-performing DL-CNB model with VGG16_BN as the feature extractor achieved an AUC of 0.816 (95% confidence interval (CI): 0.758, 0.865) in predicting positive ALN metastasis in the independent test cohort. Furthermore, our model incorporating the clinical data, which was called DL-CNB+C, yielded the best accuracy of 0.831 (95%CI: 0.775, 0.878), especially for patients younger than 50 years (AUC: 0.918, 95%CI: 0.825, 0.971). The interpretation of DL-CNB model showed that the top signatures most predictive of ALN metastasis were characterized by the nucleus features including density ($p$ = 0.015), circumference ($p$ = 0.009), circularity ($p$ = 0.010), and orientation ($p$ = 0.012). Conclusion: Our study provides a novel DL-based biomarker on primary tumor CNB slides to predict the metastatic status of ALN preoperatively for patients with EBC. The codes and dataset are available at https://github.com/bupt-ai-cz/BALNMP