Foundation Model for Advancing Healthcare: Challenges, Opportunities, and Future Directions

Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between limited AI models and diverse healthcare practices. Much more widespread healthcare scenarios will benefit from the development of a healthcare foundation model (HFM), improving their advanced intelligent healthcare services. Despite the impending widespread deployment of HFMs, there is currently a lack of clear understanding about how they work in the healthcare field, their current challenges, and where they are headed in the future. To answer these questions, a comprehensive and deep survey of the challenges, opportunities, and future directions of HFMs is presented in this survey. It first conducted a comprehensive overview of the HFM including the methods, data, and applications for a quick grasp of the current progress. Then, it made an in-depth exploration of the challenges present in data, algorithms, and computing infrastructures for constructing and widespread application of foundation models in healthcare. This survey also identifies emerging and promising directions in this field for future development. We believe that this survey will enhance the community's comprehension of the current progress of HFM and serve as a valuable source of guidance for future development in this field. The latest HFM papers and related resources are maintained on our website: https://github.com/YutingHe-list/Awesome-Foundation-Models-for-Advancing-Healthcare.

NLCG-Net: A Model-Based Zero-Shot Learning Framework for Undersampled Quantitative MRI Reconstruction

Typical quantitative MRI (qMRI) methods estimate parameter maps after image reconstructing, which is prone to biases and error propagation. We propose a Nonlinear Conjugate Gradient (NLCG) optimizer for model-based T2/T1 estimation, which incorporates U-Net regularization trained in a scan-specific manner. This end-to-end method directly estimates qMRI maps from undersampled k-space data using mono-exponential signal modeling with zero-shot scan-specific neural network regularization to enable high fidelity T1 and T2 mapping. T2 and T1 mapping results demonstrate the ability of the proposed NLCG-Net to improve estimation quality compared to subspace reconstruction at high accelerations.

Facial Attribute Capsules for Noise Face Super Resolution

Existing face super-resolution (SR) methods mainly assume the input image to be noise-free. Their performance degrades drastically when applied to real-world scenarios where the input image is always contaminated by noise. In this paper, we propose a Facial Attribute Capsules Network (FACN) to deal with the problem of high-scale super-resolution of noisy face image. Capsule is a group of neurons whose activity vector models different properties of the same entity. Inspired by the concept of capsule, we propose an integrated representation model of facial information, which named Facial Attribute Capsule (FAC). In the SR processing, we first generated a group of FACs from the input LR face, and then reconstructed the HR face from this group of FACs. Aiming to effectively improve the robustness of FAC to noise, we generate FAC in semantic, probabilistic and facial attributes manners by means of integrated learning strategy. Each FAC can be divided into two sub-capsules: Semantic Capsule (SC) and Probabilistic Capsule (PC). Them describe an explicit facial attribute in detail from two aspects of semantic representation and probability distribution. The group of FACs model an image as a combination of facial attribute information in the semantic space and probabilistic space by an attribute-disentangling way. The diverse FACs could better combine the face prior information to generate the face images with fine-grained semantic attributes. Extensive benchmark experiments show that our method achieves superior hallucination results and outperforms state-of-the-art for very low resolution (LR) noise face image super resolution.