Enhance the Image: Super Resolution using Artificial Intelligence in MRI

This chapter provides an overview of deep learning techniques for improving the spatial resolution of MRI, ranging from convolutional neural networks, generative adversarial networks, to more advanced models including transformers, diffusion models, and implicit neural representations. Our exploration extends beyond the methodologies to scrutinize the impact of super-resolved images on clinical and neuroscientific assessments. We also cover various practical topics such as network architectures, image evaluation metrics, network loss functions, and training data specifics, including downsampling methods for simulating low-resolution images and dataset selection. Finally, we discuss existing challenges and potential future directions regarding the feasibility and reliability of deep learning-based MRI super-resolution, with the aim to facilitate its wider adoption to benefit various clinical and neuroscientific applications.

Self-navigated 3D diffusion MRI using an optimized CAIPI sampling and structured low-rank reconstruction

3D multi-slab acquisitions are an appealing approach for diffusion MRI because they are compatible with the imaging regime delivering optimal SNR efficiency. In conventional 3D multi-slab imaging, shot-to-shot phase variations caused by motion pose challenges due to the use of multi-shot k-space acquisition. Navigator acquisition after each imaging echo is typically employed to correct phase variations, which prolongs scan time and increases the specific absorption rate (SAR). The aim of this study is to develop a highly efficient, self-navigated method to correct for phase variations in 3D multi-slab diffusion MRI without explicitly acquiring navigators. The sampling of each shot is carefully designed to intersect with the central kz plane of each slab, and the multi-shot sampling is optimized for self-navigation performance while retaining decent reconstruction quality. The central kz intersections from all shots are jointly used to reconstruct a 2D phase map for each shot using a structured low-rank constrained reconstruction that leverages the redundancy in shot and coil dimensions. The phase maps are used to eliminate the shot-to-shot phase inconsistency in the final 3D multi-shot reconstruction. We demonstrate the method's efficacy using retrospective simulations and prospectively acquired in-vivo experiments at 1.22 mm and 1.09 mm isotropic resolutions. Compared to conventional navigated 3D multi-slab imaging, the proposed self-navigated method achieves comparable image quality while shortening the scan time by 31.7% and improving the SNR efficiency by 15.5%. The proposed method produces comparable quality of DTI and white matter tractography to conventional navigated 3D multi-slab acquisition with a much shorter scan time.

Bi-level Off-policy Reinforcement Learning for Volt/VAR Control Involving Continuous and Discrete Devices

In Volt/Var control (VVC) of active distribution networks(ADNs), both slow timescale discrete devices (STDDs) and fast timescale continuous devices (FTCDs) are involved. The STDDs such as on-load tap changers (OLTC) and FTCDs such as distributed generators should be coordinated in time sequence. Such VCC is formulated as a two-timescale optimization problem to jointly optimize FTCDs and STDDs in ADNs. Traditional optimization methods are heavily based on accurate models of the system, but sometimes impractical because of their unaffordable effort on modelling. In this paper, a novel bi-level off-policy reinforcement learning (RL) algorithm is proposed to solve this problem in a model-free manner. A Bi-level Markov decision process (BMDP) is defined to describe the two-timescale VVC problem and separate agents are set up for the slow and fast timescale sub-problems. For the fast timescale sub-problem, we adopt an off-policy RL method soft actor-critic with high sample efficiency. For the slow one, we develop an off-policy multi-discrete soft actor-critic (MDSAC) algorithm to address the curse of dimensionality with various STDDs. To mitigate the non-stationary issue existing the two agents' learning processes, we propose a multi-timescale off-policy correction (MTOPC) method by adopting importance sampling technique. Comprehensive numerical studies not only demonstrate that the proposed method can achieve stable and satisfactory optimization of both STDDs and FTCDs without any model information, but also support that the proposed method outperforms existing two-timescale VVC methods.

Online Multi-agent Reinforcement Learning for Decentralized Inverter-based Volt-VAR Control

The distributed Volt/Var control (VVC) methods have been widely studied for active distribution networks(ADNs), which is based on perfect model and real-time P2P communication. However, the model is always incomplete with significant parameter errors and such P2P communication system is hard to maintain. In this paper, we propose an online multi-agent reinforcement learning and decentralized control framework (OLDC) for VVC. In this framework, the VVC problem is formulated as a constrained Markov game and we propose a novel multi-agent constrained soft actor-critic (MACSAC) reinforcement learning algorithm. MACSAC is used to train the control agents online, so the accurate ADN model is no longer needed. Then, the trained agents can realize decentralized optimal control using local measurements without real-time P2P communication. The OLDC with MACSAC has shown extraordinary flexibility, efficiency and robustness to various computing and communication conditions. Numerical simulations on IEEE test cases not only demonstrate that the proposed MACSAC outperforms the state-of-art learning algorithms, but also support the superiority of our OLDC framework in the online application.

Two-stage Deep Reinforcement Learning for Inverter-based Volt-VAR Control in Active Distribution Networks

Model-based Vol/VAR optimization method is widely used to eliminate voltage violations and reduce network losses. However, the parameters of active distribution networks(ADNs) are not onsite identified, so significant errors may be involved in the model and make the model-based method infeasible. To cope with this critical issue, we propose a novel two-stage deep reinforcement learning (DRL) method to improve the voltage profile by regulating inverter-based energy resources, which consists of offline stage and online stage. In the offline stage, a highly efficient adversarial reinforcement learning algorithm is developed to train an offline agent robust to the model mismatch. In the sequential online stage, we transfer the offline agent safely as the online agent to perform continuous learning and controlling online with significantly improved safety and efficiency. Numerical simulations on IEEE test cases not only demonstrate that the proposed adversarial reinforcement learning algorithm outperforms the state-of-art algorithm, but also show that our proposed two-stage method achieves much better performance than the existing DRL based methods in the online application.

Human-like machine thinking: Language guided imagination

Human thinking requires the brain to understand the meaning of language expression and to properly organize the thoughts flow using the language. However, current natural language processing models are primarily limited in the word probability estimation. Here, we proposed a Language guided imagination (LGI) network to incrementally learn the meaning and usage of numerous words and syntaxes, aiming to form a human-like machine thinking process. LGI contains three subsystems: (1) vision system that contains an encoder to disentangle the input or imagined scenarios into abstract population representations, and an imagination decoder to reconstruct imagined scenario from higher level representations; (2) Language system, that contains a binarizer to transfer symbol texts into binary vectors, an IPS (mimicking the human IntraParietal Sulcus, implemented by an LSTM) to extract the quantity information from the input texts, and a textizer to convert binary vectors into text symbols; (3) a PFC (mimicking the human PreFrontal Cortex, implemented by an LSTM) to combine inputs of both language and vision representations, and predict text symbols and manipulated images accordingly. LGI has incrementally learned eight different syntaxes (or tasks), with which a machine thinking loop has been formed and validated by the proper interaction between language and vision system. The paper provides a new architecture to let the machine learn, understand and use language in a human-like way that could ultimately enable a machine to construct fictitious 'mental' scenario and possess intelligence.