Structured Gradient-based Interpretations via Norm-Regularized Adversarial Training

Gradient-based saliency maps have been widely used to explain the decisions of deep neural network classifiers. However, standard gradient-based interpretation maps, including the simple gradient and integrated gradient algorithms, often lack desired structures such as sparsity and connectedness in their application to real-world computer vision models. A frequently used approach to inducing sparsity structures into gradient-based saliency maps is to alter the simple gradient scheme using sparsification or norm-based regularization. A drawback with such post-processing methods is their frequently-observed significant loss in fidelity to the original simple gradient map. In this work, we propose to apply adversarial training as an in-processing scheme to train neural networks with structured simple gradient maps. We show a duality relation between the regularized norms of the adversarial perturbations and gradient-based maps, based on which we design adversarial training loss functions promoting sparsity and group-sparsity properties in simple gradient maps. We present several numerical results to show the influence of our proposed norm-based adversarial training methods on the standard gradient-based maps of standard neural network architectures on benchmark image datasets.

3DSAM-adapter: Holistic Adaptation of SAM from 2D to 3D for Promptable Medical Image Segmentation

Despite that the segment anything model (SAM) achieved impressive results on general-purpose semantic segmentation with strong generalization ability on daily images, its demonstrated performance on medical image segmentation is less precise and not stable, especially when dealing with tumor segmentation tasks that involve objects of small sizes, irregular shapes, and low contrast. Notably, the original SAM architecture is designed for 2D natural images, therefore would not be able to extract the 3D spatial information from volumetric medical data effectively. In this paper, we propose a novel adaptation method for transferring SAM from 2D to 3D for promptable medical image segmentation. Through a holistically designed scheme for architecture modification, we transfer the SAM to support volumetric inputs while retaining the majority of its pre-trained parameters for reuse. The fine-tuning process is conducted in a parameter-efficient manner, wherein most of the pre-trained parameters remain frozen, and only a few lightweight spatial adapters are introduced and tuned. Regardless of the domain gap between natural and medical data and the disparity in the spatial arrangement between 2D and 3D, the transformer trained on natural images can effectively capture the spatial patterns present in volumetric medical images with only lightweight adaptations. We conduct experiments on four open-source tumor segmentation datasets, and with a single click prompt, our model can outperform domain state-of-the-art medical image segmentation models on 3 out of 4 tasks, specifically by 8.25%, 29.87%, and 10.11% for kidney tumor, pancreas tumor, colon cancer segmentation, and achieve similar performance for liver tumor segmentation. We also compare our adaptation method with existing popular adapters, and observed significant performance improvement on most datasets.

Diffusion Model based Semi-supervised Learning on Brain Hemorrhage Images for Efficient Midline Shift Quantification

Brain midline shift (MLS) is one of the most critical factors to be considered for clinical diagnosis and treatment decision-making for intracranial hemorrhage. Existing computational methods on MLS quantification not only require intensive labeling in millimeter-level measurement but also suffer from poor performance due to their dependence on specific landmarks or simplified anatomical assumptions. In this paper, we propose a novel semi-supervised framework to accurately measure the scale of MLS from head CT scans. We formulate the MLS measurement task as a deformation estimation problem and solve it using a few MLS slices with sparse labels. Meanwhile, with the help of diffusion models, we are able to use a great number of unlabeled MLS data and 2793 non-MLS cases for representation learning and regularization. The extracted representation reflects how the image is different from a non-MLS image and regularization serves an important role in the sparse-to-dense refinement of the deformation field. Our experiment on a real clinical brain hemorrhage dataset has achieved state-of-the-art performance and can generate interpretable deformation fields.