Investigation of risk-aware MDP and POMDP contingency management autonomy for UAS

Unmanned aircraft systems (UAS) are being increasingly adopted for various applications. The risk UAS poses to people and property must be kept to acceptable levels. This paper proposes risk-aware contingency management autonomy to prevent an accident in the event of component malfunction, specifically propulsion unit failure and/or battery degradation. The proposed autonomy is modeled as a Markov Decision Process (MDP) whose solution is a contingency management policy that appropriately executes emergency landing, flight termination or continuation of planned flight actions. Motivated by the potential for errors in fault/failure indicators, partial observability of the MDP state space is investigated. The performance of optimal policies is analyzed over varying observability conditions in a high-fidelity simulator. Results indicate that both partially observable MDP (POMDP) and maximum a posteriori MDP policies performed similarly over different state observability criteria, given the nearly deterministic state transition model.

Deep Reinforcement Learning for Cost-Effective Medical Diagnosis

Dynamic diagnosis is desirable when medical tests are costly or time-consuming. In this work, we use reinforcement learning (RL) to find a dynamic policy that selects lab test panels sequentially based on previous observations, ensuring accurate testing at a low cost. Clinical diagnostic data are often highly imbalanced; therefore, we aim to maximize the $F_1$ score instead of the error rate. However, optimizing the non-concave $F_1$ score is not a classic RL problem, thus invalidates standard RL methods. To remedy this issue, we develop a reward shaping approach, leveraging properties of the $F_1$ score and duality of policy optimization, to provably find the set of all Pareto-optimal policies for budget-constrained $F_1$ score maximization. To handle the combinatorially complex state space, we propose a Semi-Model-based Deep Diagnosis Policy Optimization (SM-DDPO) framework that is compatible with end-to-end training and online learning. SM-DDPO is tested on diverse clinical tasks: ferritin abnormality detection, sepsis mortality prediction, and acute kidney injury diagnosis. Experiments with real-world data validate that SM-DDPO trains efficiently and identifies all Pareto-front solutions. Across all tasks, SM-DDPO is able to achieve state-of-the-art diagnosis accuracy (in some cases higher than conventional methods) with up to $85\%$ reduction in testing cost. The code is available at [https://github.com/Zheng321/Deep-Reinforcement-Learning-for-Cost-Effective-Medical-Diagnosis].

PHEE: A Dataset for Pharmacovigilance Event Extraction from Text

The primary goal of drug safety researchers and regulators is to promptly identify adverse drug reactions. Doing so may in turn prevent or reduce the harm to patients and ultimately improve public health. Evaluating and monitoring drug safety (i.e., pharmacovigilance) involves analyzing an ever growing collection of spontaneous reports from health professionals, physicians, and pharmacists, and information voluntarily submitted by patients. In this scenario, facilitating analysis of such reports via automation has the potential to rapidly identify safety signals. Unfortunately, public resources for developing natural language models for this task are scant. We present PHEE, a novel dataset for pharmacovigilance comprising over 5000 annotated events from medical case reports and biomedical literature, making it the largest such public dataset to date. We describe the hierarchical event schema designed to provide coarse and fine-grained information about patients' demographics, treatments and (side) effects. Along with the discussion of the dataset, we present a thorough experimental evaluation of current state-of-the-art approaches for biomedical event extraction, point out their limitations, and highlight open challenges to foster future research in this area.

Joint Modeling of Content and Discourse Relations in Dialogues

We present a joint modeling approach to identify salient discussion points in spoken meetings as well as to label the discourse relations between speaker turns. A variation of our model is also discussed when discourse relations are treated as latent variables. Experimental results on two popular meeting corpora show that our joint model can outperform state-of-the-art approaches for both phrase-based content selection and discourse relation prediction tasks. We also evaluate our model on predicting the consistency among team members' understanding of their group decisions. Classifiers trained with features constructed from our model achieve significant better predictive performance than the state-of-the-art.