Rapid Reconstruction of Extremely Accelerated Liver 4D MRI via Chained Iterative Refinement

Abstract Purpose: High-quality 4D MRI requires an impractically long scanning time for dense k-space signal acquisition covering all respiratory phases. Accelerated sparse sampling followed by reconstruction enhancement is desired but often results in degraded image quality and long reconstruction time. We hereby propose the chained iterative reconstruction network (CIRNet) for efficient sparse-sampling reconstruction while maintaining clinically deployable quality. Methods: CIRNet adopts the denoising diffusion probabilistic framework to condition the image reconstruction through a stochastic iterative denoising process. During training, a forward Markovian diffusion process is designed to gradually add Gaussian noise to the densely sampled ground truth (GT), while CIRNet is optimized to iteratively reverse the Markovian process from the forward outputs. At the inference stage, CIRNet performs the reverse process solely to recover signals from noise, conditioned upon the undersampled input. CIRNet processed the 4D data (3D+t) as temporal slices (2D+t). The proposed framework is evaluated on a data cohort consisting of 48 patients (12332 temporal slices) who underwent free-breathing liver 4D MRI. 3-, 6-, 10-, 20- and 30-times acceleration were examined with a retrospective random undersampling scheme. Compressed sensing (CS) reconstruction with a spatiotemporal constraint and a recently proposed deep network, Re-Con-GAN, are selected as baselines. Results: CIRNet consistently achieved superior performance compared to CS and Re-Con-GAN. The inference time of CIRNet, CS, and Re-Con-GAN are 11s, 120s, and 0.15s. Conclusion: A novel framework, CIRNet, is presented. CIRNet maintains useable image quality for acceleration up to 30 times, significantly reducing the burden of 4DMRI.

Paired Conditional Generative Adversarial Network for Highly Accelerated Liver 4D MRI

Purpose: 4D MRI with high spatiotemporal resolution is desired for image-guided liver radiotherapy. Acquiring densely sampling k-space data is time-consuming. Accelerated acquisition with sparse samples is desirable but often causes degraded image quality or long reconstruction time. We propose the Reconstruct Paired Conditional Generative Adversarial Network (Re-Con-GAN) to shorten the 4D MRI reconstruction time while maintaining the reconstruction quality. Methods: Patients who underwent free-breathing liver 4D MRI were included in the study. Fully- and retrospectively under-sampled data at 3, 6 and 10 times (3x, 6x and 10x) were first reconstructed using the nuFFT algorithm. Re-Con-GAN then trained input and output in pairs. Three types of networks, ResNet9, UNet and reconstruction swin transformer, were explored as generators. PatchGAN was selected as the discriminator. Re-Con-GAN processed the data (3D+t) as temporal slices (2D+t). A total of 48 patients with 12332 temporal slices were split into training (37 patients with 10721 slices) and test (11 patients with 1611 slices). Results: Re-Con-GAN consistently achieved comparable/better PSNR, SSIM, and RMSE scores compared to CS/UNet models. The inference time of Re-Con-GAN, UNet and CS are 0.15s, 0.16s, and 120s. The GTV detection task showed that Re-Con-GAN and CS, compared to UNet, better improved the dice score (3x Re-Con-GAN 80.98%; 3x CS 80.74%; 3x UNet 79.88%) of unprocessed under-sampled images (3x 69.61%). Conclusion: A generative network with adversarial training is proposed with promising and efficient reconstruction results demonstrated on an in-house dataset. The rapid and qualitative reconstruction of 4D liver MR has the potential to facilitate online adaptive MR-guided radiotherapy for liver cancer.

Physics-driven Deep Learning for PET/MRI

In this paper, we review physics- and data-driven reconstruction techniques for simultaneous positron emission tomography (PET) / magnetic resonance imaging (MRI) systems, which have significant advantages for clinical imaging of cancer, neurological disorders, and heart disease. These reconstruction approaches utilize priors, either structural or statistical, together with a physics-based description of the PET system response. However, due to the nested representation of the forward problem, direct PET/MRI reconstruction is a nonlinear problem. We elucidate how a multi-faceted approach accommodates hybrid data- and physics-driven machine learning for reconstruction of 3D PET/MRI, summarizing important deep learning developments made in the last 5 years to address attenuation correction, scattering, low photon counts, and data consistency. We also describe how applications of these multi-modality approaches extend beyond PET/MRI to improving accuracy in radiation therapy planning. We conclude by discussing opportunities for extending the current state-of-the-art following the latest trends in physics- and deep learning-based computational imaging and next-generation detector hardware.