Paired Conditional Generative Adversarial Network for Highly Accelerated Liver 4D MRI

Purpose: 4D MRI with high spatiotemporal resolution is desired for image-guided liver radiotherapy. Acquiring densely sampling k-space data is time-consuming. Accelerated acquisition with sparse samples is desirable but often causes degraded image quality or long reconstruction time. We propose the Reconstruct Paired Conditional Generative Adversarial Network (Re-Con-GAN) to shorten the 4D MRI reconstruction time while maintaining the reconstruction quality. Methods: Patients who underwent free-breathing liver 4D MRI were included in the study. Fully- and retrospectively under-sampled data at 3, 6 and 10 times (3x, 6x and 10x) were first reconstructed using the nuFFT algorithm. Re-Con-GAN then trained input and output in pairs. Three types of networks, ResNet9, UNet and reconstruction swin transformer, were explored as generators. PatchGAN was selected as the discriminator. Re-Con-GAN processed the data (3D+t) as temporal slices (2D+t). A total of 48 patients with 12332 temporal slices were split into training (37 patients with 10721 slices) and test (11 patients with 1611 slices). Results: Re-Con-GAN consistently achieved comparable/better PSNR, SSIM, and RMSE scores compared to CS/UNet models. The inference time of Re-Con-GAN, UNet and CS are 0.15s, 0.16s, and 120s. The GTV detection task showed that Re-Con-GAN and CS, compared to UNet, better improved the dice score (3x Re-Con-GAN 80.98%; 3x CS 80.74%; 3x UNet 79.88%) of unprocessed under-sampled images (3x 69.61%). Conclusion: A generative network with adversarial training is proposed with promising and efficient reconstruction results demonstrated on an in-house dataset. The rapid and qualitative reconstruction of 4D liver MR has the potential to facilitate online adaptive MR-guided radiotherapy for liver cancer.

Advancing low-field MRI with a universal denoising imaging transformer: Towards fast and high-quality imaging

Recent developments in low-field (LF) magnetic resonance imaging (MRI) systems present remarkable opportunities for affordable and widespread MRI access. A robust denoising method to overcome the intrinsic low signal-noise-ratio (SNR) barrier is critical to the success of LF MRI. However, current data-driven MRI denoising methods predominantly handle magnitude images and rely on customized models with constrained data diversity and quantity, which exhibit limited generalizability in clinical applications across diverse MRI systems, pulse sequences, and organs. In this study, we present ImT-MRD: a complex-valued imaging transformer trained on a vast number of clinical MRI scans aiming at universal MR denoising at LF systems. Compared with averaging multiple-repeated scans for higher image SNR, the model obtains better image quality from fewer repetitions, demonstrating its capability for accelerating scans under various clinical settings. Moreover, with its complex-valued image input, the model can denoise intermediate results before advanced post-processing and prepare high-quality data for further MRI research. By delivering universal and accurate denoising across clinical and research tasks, our model holds great promise to expedite the evolution of LF MRI for accessible and equal biomedical applications.