Health AI Developer Foundations

Robust medical Machine Learning (ML) models have the potential to revolutionize healthcare by accelerating clinical research, improving workflows and outcomes, and producing novel insights or capabilities. Developing such ML models from scratch is cost prohibitive and requires substantial compute, data, and time (e.g., expert labeling). To address these challenges, we introduce Health AI Developer Foundations (HAI-DEF), a suite of pre-trained, domain-specific foundation models, tools, and recipes to accelerate building ML for health applications. The models cover various modalities and domains, including radiology (X-rays and computed tomography), histopathology, dermatological imaging, and audio. These models provide domain specific embeddings that facilitate AI development with less labeled data, shorter training times, and reduced computational costs compared to traditional approaches. In addition, we utilize a common interface and style across these models, and prioritize usability to enable developers to integrate HAI-DEF efficiently. We present model evaluations across various tasks and conclude with a discussion of their application and evaluation, covering the importance of ensuring efficacy, fairness, and equity. Finally, while HAI-DEF and specifically the foundation models lower the barrier to entry for ML in healthcare, we emphasize the importance of validation with problem- and population-specific data for each desired usage setting. This technical report will be updated over time as more modalities and features are added.

A study on Deep Convolutional Neural Networks, Transfer Learning and Ensemble Model for Breast Cancer Detection

In deep learning, transfer learning and ensemble models have shown promise in improving computer-aided disease diagnosis. However, applying the transfer learning and ensemble model is still relatively limited. Moreover, the ensemble model's development is ad-hoc, overlooks redundant layers, and suffers from imbalanced datasets and inadequate augmentation. Lastly, significant Deep Convolutional Neural Networks (D-CNNs) have been introduced to detect and classify breast cancer. Still, very few comparative studies were conducted to investigate the accuracy and efficiency of existing CNN architectures. Realising the gaps, this study compares the performance of D-CNN, which includes the original CNN, transfer learning, and an ensemble model, in detecting breast cancer. The comparison study of this paper consists of comparison using six CNN-based deep learning architectures (SE-ResNet152, MobileNetV2, VGG19, ResNet18, InceptionV3, and DenseNet-121), a transfer learning, and an ensemble model on breast cancer detection. Among the comparison of these models, the ensemble model provides the highest detection and classification accuracy of 99.94% for breast cancer detection and classification. However, this study also provides a negative result in the case of transfer learning, as the transfer learning did not increase the accuracy of the original SE-ResNet152, MobileNetV2, VGG19, ResNet18, InceptionV3, and DenseNet-121 model. The high accuracy in detecting and categorising breast cancer detection using CNN suggests that the CNN model is promising in breast cancer disease detection. This research is significant in biomedical engineering, computer-aided disease diagnosis, and ML-based disease detection.

PathAlign: A vision-language model for whole slide images in histopathology

Microscopic interpretation of histopathology images underlies many important diagnostic and treatment decisions. While advances in vision-language modeling raise new opportunities for analysis of such images, the gigapixel-scale size of whole slide images (WSIs) introduces unique challenges. Additionally, pathology reports simultaneously highlight key findings from small regions while also aggregating interpretation across multiple slides, often making it difficult to create robust image-text pairs. As such, pathology reports remain a largely untapped source of supervision in computational pathology, with most efforts relying on region-of-interest annotations or self-supervision at the patch-level. In this work, we develop a vision-language model based on the BLIP-2 framework using WSIs paired with curated text from pathology reports. This enables applications utilizing a shared image-text embedding space, such as text or image retrieval for finding cases of interest, as well as integration of the WSI encoder with a frozen large language model (LLM) for WSI-based generative text capabilities such as report generation or AI-in-the-loop interactions. We utilize a de-identified dataset of over 350,000 WSIs and diagnostic text pairs, spanning a wide range of diagnoses, procedure types, and tissue types. We present pathologist evaluation of text generation and text retrieval using WSI embeddings, as well as results for WSI classification and workflow prioritization (slide-level triaging). Model-generated text for WSIs was rated by pathologists as accurate, without clinically significant error or omission, for 78% of WSIs on average. This work demonstrates exciting potential capabilities for language-aligned WSI embeddings.

Advancing Multimodal Medical Capabilities of Gemini

Many clinical tasks require an understanding of specialized data, such as medical images and genomics, which is not typically found in general-purpose large multimodal models. Building upon Gemini's multimodal models, we develop several models within the new Med-Gemini family that inherit core capabilities of Gemini and are optimized for medical use via fine-tuning with 2D and 3D radiology, histopathology, ophthalmology, dermatology and genomic data. Med-Gemini-2D sets a new standard for AI-based chest X-ray (CXR) report generation based on expert evaluation, exceeding previous best results across two separate datasets by an absolute margin of 1% and 12%, where 57% and 96% of AI reports on normal cases, and 43% and 65% on abnormal cases, are evaluated as "equivalent or better" than the original radiologists' reports. We demonstrate the first ever large multimodal model-based report generation for 3D computed tomography (CT) volumes using Med-Gemini-3D, with 53% of AI reports considered clinically acceptable, although additional research is needed to meet expert radiologist reporting quality. Beyond report generation, Med-Gemini-2D surpasses the previous best performance in CXR visual question answering (VQA) and performs well in CXR classification and radiology VQA, exceeding SoTA or baselines on 17 of 20 tasks. In histopathology, ophthalmology, and dermatology image classification, Med-Gemini-2D surpasses baselines across 18 out of 20 tasks and approaches task-specific model performance. Beyond imaging, Med-Gemini-Polygenic outperforms the standard linear polygenic risk score-based approach for disease risk prediction and generalizes to genetically correlated diseases for which it has never been trained. Although further development and evaluation are necessary in the safety-critical medical domain, our results highlight the potential of Med-Gemini across a wide range of medical tasks.

A Comprehensive Literature Review on Sweet Orange Leaf Diseases

Sweet orange leaf diseases are significant to agricultural productivity. Leaf diseases impact fruit quality in the citrus industry. The apparition of machine learning makes the development of disease finder. Early detection and diagnosis are necessary for leaf management. Sweet orange leaf disease-predicting automated systems have already been developed using different image-processing techniques. This comprehensive literature review is systematically based on leaf disease and machine learning methodologies applied to the detection of damaged leaves via image classification. The benefits and limitations of different machine learning models, including Vision Transformer (ViT), Neural Network (CNN), CNN with SoftMax and RBF SVM, Hybrid CNN-SVM, HLB-ConvMLP, EfficientNet-b0, YOLOv5, YOLOv7, Convolutional, Deep CNN. These machine learning models tested on various datasets and detected the disease. This comprehensive review study related to leaf disease compares the performance of the models; those models' accuracy, precision, recall, etc., were used in the subsisting studies

Machine Learning-Based Tea Leaf Disease Detection: A Comprehensive Review

Tea leaf diseases are a major challenge to agricultural productivity, with far-reaching implications for yield and quality in the tea industry. The rise of machine learning has enabled the development of innovative approaches to combat these diseases. Early detection and diagnosis are crucial for effective crop management. For predicting tea leaf disease, several automated systems have already been developed using different image processing techniques. This paper delivers a systematic review of the literature on machine learning methodologies applied to diagnose tea leaf disease via image classification. It thoroughly evaluates the strengths and constraints of various Vision Transformer models, including Inception Convolutional Vision Transformer (ICVT), GreenViT, PlantXViT, PlantViT, MSCVT, Transfer Learning Model & Vision Transformer (TLMViT), IterationViT, IEM-ViT. Moreover, this paper also reviews models like Dense Convolutional Network (DenseNet), Residual Neural Network (ResNet)-50V2, YOLOv5, YOLOv7, Convolutional Neural Network (CNN), Deep CNN, Non-dominated Sorting Genetic Algorithm (NSGA-II), MobileNetv2, and Lesion-Aware Visual Transformer. These machine-learning models have been tested on various datasets, demonstrating their real-world applicability. This review study not only highlights current progress in the field but also provides valuable insights for future research directions in the machine learning-based detection and classification of tea leaf diseases.

Domain-specific optimization and diverse evaluation of self-supervised models for histopathology

Task-specific deep learning models in histopathology offer promising opportunities for improving diagnosis, clinical research, and precision medicine. However, development of such models is often limited by availability of high-quality data. Foundation models in histopathology that learn general representations across a wide range of tissue types, diagnoses, and magnifications offer the potential to reduce the data, compute, and technical expertise necessary to develop task-specific deep learning models with the required level of model performance. In this work, we describe the development and evaluation of foundation models for histopathology via self-supervised learning (SSL). We first establish a diverse set of benchmark tasks involving 17 unique tissue types and 12 unique cancer types and spanning different optimal magnifications and task types. Next, we use this benchmark to explore and evaluate histopathology-specific SSL methods followed by further evaluation on held out patch-level and weakly supervised tasks. We found that standard SSL methods thoughtfully applied to histopathology images are performant across our benchmark tasks and that domain-specific methodological improvements can further increase performance. Our findings reinforce the value of using domain-specific SSL methods in pathology, and establish a set of high quality foundation models to enable further research across diverse applications.

Integrating Categorical Semantics into Unsupervised Domain Translation

While unsupervised domain translation (UDT) has seen a lot of success recently, we argue that allowing its translation to be mediated via categorical semantic features could enable wider applicability. In particular, we argue that categorical semantics are important when translating between domains with multiple object categories possessing distinctive styles, or even between domains that are simply too different but still share high-level semantics. We propose a method to learn, in an unsupervised manner, categorical semantic features (such as object labels) that are invariant of the source and target domains. We show that conditioning the style of a unsupervised domain translation methods on the learned categorical semantics leads to a considerably better high-level features preservation on tasks such as MNIST$\leftrightarrow$SVHN and to a more realistic stylization on Sketches$\to$Reals.

Virtual Experience to Real World Application: Sidewalk Obstacle Avoidance Using Reinforcement Learning for Visually Impaired

Finding a path free from obstacles that poses minimal risk is critical for safe navigation. People who are sighted and people who are visually impaired require navigation safety while walking on a sidewalk. In this research we developed an assistive navigation on a sidewalk by integrating sensory inputs using reinforcement learning. We trained a Sidewalk Obstacle Avoidance Agent (SOAA) through reinforcement learning in a simulated robotic environment. A Sidewalk Obstacle Conversational Agent (SOCA) is built by training a natural language conversation agent with real conversation data. The SOAA along with SOCA was integrated in a prototype device called augmented guide (AG). Empirical analysis showed that this prototype improved the obstacle avoidance experience about 5% from a base case of 81.29%

Detecting semantic anomalies

We critically appraise the recent interest in out-of-distribution (OOD) detection and question the practical relevance of existing benchmarks. While the currently prevalent trend is to consider different datasets as OOD, we posit that out-distributions of practical interest are ones where the distinction is semantic in nature for a specified context, and evaluative tasks should reflect this more closely. Assuming a context of object recognition, we recommend a set of benchmarks, motivated by referencing practical applications. Finally, we explore a multi-task learning based approach and show empirically that auxiliary objectives for improved semantic awareness can result in improved semantic anomaly detection, with accompanying generalization benefits.