Decentralised, Collaborative, and Privacy-preserving Machine Learning for Multi-Hospital Data

Machine Learning (ML) has demonstrated its great potential on medical data analysis. Large datasets collected from diverse sources and settings are essential for ML models in healthcare to achieve better accuracy and generalizability. Sharing data across different healthcare institutions is challenging because of complex and varying privacy and regulatory requirements. Hence, it is hard but crucial to allow multiple parties to collaboratively train an ML model leveraging the private datasets available at each party without the need for direct sharing of those datasets or compromising the privacy of the datasets through collaboration. In this paper, we address this challenge by proposing Decentralized, Collaborative, and Privacy-preserving ML for Multi-Hospital Data (DeCaPH). It offers the following key benefits: (1) it allows different parties to collaboratively train an ML model without transferring their private datasets; (2) it safeguards patient privacy by limiting the potential privacy leakage arising from any contents shared across the parties during the training process; and (3) it facilitates the ML model training without relying on a centralized server. We demonstrate the generalizability and power of DeCaPH on three distinct tasks using real-world distributed medical datasets: patient mortality prediction using electronic health records, cell-type classification using single-cell human genomes, and pathology identification using chest radiology images. We demonstrate that the ML models trained with DeCaPH framework have an improved utility-privacy trade-off, showing it enables the models to have good performance while preserving the privacy of the training data points. In addition, the ML models trained with DeCaPH framework in general outperform those trained solely with the private datasets from individual parties, showing that DeCaPH enhances the model generalizability.

FENDA-FL: Personalized Federated Learning on Heterogeneous Clinical Datasets

Federated learning (FL) is increasingly being recognized as a key approach to overcoming the data silos that so frequently obstruct the training and deployment of machine-learning models in clinical settings. This work contributes to a growing body of FL research specifically focused on clinical applications along three important directions. First, an extension of the FENDA method (Kim et al., 2016) to the FL setting is proposed. Experiments conducted on the FLamby benchmarks (du Terrail et al., 2022a) and GEMINI datasets (Verma et al., 2017) show that the approach is robust to heterogeneous clinical data and often outperforms existing global and personalized FL techniques. Further, the experimental results represent substantive improvements over the original FLamby benchmarks and expand such benchmarks to include evaluation of personalized FL methods. Finally, we advocate for a comprehensive checkpointing and evaluation framework for FL to better reflect practical settings and provide multiple baselines for comparison.

Assessing the impact of emergency department short stay units using length-of-stay prediction and discrete event simulation

Accurately predicting hospital length-of-stay at the time a patient is admitted to hospital may help guide clinical decision making and resource allocation. In this study we aim to build a decision support system that predicts hospital length-of-stay for patients admitted to general internal medicine from the emergency department. We conduct an exploratory data analysis and employ feature selection methods to identify the attributes that result in the best predictive performance. We also develop a discrete-event simulation model to assess the performances of the prediction models in a practical setting. Our results show that the recommendation performances of the proposed approaches are generally acceptable and do not benefit from the feature selection. Further, the results indicate that hospital length-of-stay could be predicted with reasonable accuracy (e.g., AUC value for classifying short and long stay patients is 0.69) using patient admission demographics, laboratory test results, diagnostic imaging, vital signs and clinical documentation.