MAST-Pro: Dynamic Mixture-of-Experts for Adaptive Segmentation of Pan-Tumors with Knowledge-Driven Prompts

Accurate tumor segmentation is crucial for cancer diagnosis and treatment. While foundation models have advanced general-purpose segmentation, existing methods still struggle with: (1) limited incorporation of medical priors, (2) imbalance between generic and tumor-specific features, and (3) high computational costs for clinical adaptation. To address these challenges, we propose MAST-Pro (Mixture-of-experts for Adaptive Segmentation of pan-Tumors with knowledge-driven Prompts), a novel framework that integrates dynamic Mixture-of-Experts (D-MoE) and knowledge-driven prompts for pan-tumor segmentation. Specifically, text and anatomical prompts provide domain-specific priors, guiding tumor representation learning, while D-MoE dynamically selects experts to balance generic and tumor-specific feature learning, improving segmentation accuracy across diverse tumor types. To enhance efficiency, we employ Parameter-Efficient Fine-Tuning (PEFT), optimizing MAST-Pro with significantly reduced computational overhead. Experiments on multi-anatomical tumor datasets demonstrate that MAST-Pro outperforms state-of-the-art approaches, achieving up to a 5.20% improvement in average DSC while reducing trainable parameters by 91.04%, without compromising accuracy.

A General Framework for Producing Interpretable Semantic Text Embeddings

Semantic text embedding is essential to many tasks in Natural Language Processing (NLP). While black-box models are capable of generating high-quality embeddings, their lack of interpretability limits their use in tasks that demand transparency. Recent approaches have improved interpretability by leveraging domain-expert-crafted or LLM-generated questions, but these methods rely heavily on expert input or well-prompt design, which restricts their generalizability and ability to generate discriminative questions across a wide range of tasks. To address these challenges, we introduce \algo{CQG-MBQA} (Contrastive Question Generation - Multi-task Binary Question Answering), a general framework for producing interpretable semantic text embeddings across diverse tasks. Our framework systematically generates highly discriminative, low cognitive load yes/no questions through the \algo{CQG} method and answers them efficiently with the \algo{MBQA} model, resulting in interpretable embeddings in a cost-effective manner. We validate the effectiveness and interpretability of \algo{CQG-MBQA} through extensive experiments and ablation studies, demonstrating that it delivers embedding quality comparable to many advanced black-box models while maintaining inherently interpretability. Additionally, \algo{CQG-MBQA} outperforms other interpretable text embedding methods across various downstream tasks.

Diversity-Aware $k$-Maximum Inner Product Search Revisited

The $k$-Maximum Inner Product Search ($k$MIPS) serves as a foundational component in recommender systems and various data mining tasks. However, while most existing $k$MIPS approaches prioritize the efficient retrieval of highly relevant items for users, they often neglect an equally pivotal facet of search results: \emph{diversity}. To bridge this gap, we revisit and refine the diversity-aware $k$MIPS (D$k$MIPS) problem by incorporating two well-known diversity objectives -- minimizing the average and maximum pairwise item similarities within the results -- into the original relevance objective. This enhancement, inspired by Maximal Marginal Relevance (MMR), offers users a controllable trade-off between relevance and diversity. We introduce \textsc{Greedy} and \textsc{DualGreedy}, two linear scan-based algorithms tailored for D$k$MIPS. They both achieve data-dependent approximations and, when aiming to minimize the average pairwise similarity, \textsc{DualGreedy} attains an approximation ratio of $1/4$ with an additive term for regularization. To further improve query efficiency, we integrate a lightweight Ball-Cone Tree (BC-Tree) index with the two algorithms. Finally, comprehensive experiments on ten real-world data sets demonstrate the efficacy of our proposed methods, showcasing their capability to efficiently deliver diverse and relevant search results to users.