Differentially Private Video Activity Recognition

In recent years, differential privacy has seen significant advancements in image classification; however, its application to video activity recognition remains under-explored. This paper addresses the challenges of applying differential privacy to video activity recognition, which primarily stem from: (1) a discrepancy between the desired privacy level for entire videos and the nature of input data processed by contemporary video architectures, which are typically short, segmented clips; and (2) the complexity and sheer size of video datasets relative to those in image classification, which render traditional differential privacy methods inadequate. To tackle these issues, we propose Multi-Clip DP-SGD, a novel framework for enforcing video-level differential privacy through clip-based classification models. This method samples multiple clips from each video, averages their gradients, and applies gradient clipping in DP-SGD without incurring additional privacy loss. Moreover, we incorporate a parameter-efficient transfer learning strategy to make the model scalable for large-scale video datasets. Through extensive evaluations on the UCF-101 and HMDB-51 datasets, our approach exhibits impressive performance, achieving 81% accuracy with a privacy budget of epsilon=5 on UCF-101, marking a 76% improvement compared to a direct application of DP-SGD. Furthermore, we demonstrate that our transfer learning strategy is versatile and can enhance differentially private image classification across an array of datasets including CheXpert, ImageNet, CIFAR-10, and CIFAR-100.

ChatGPT-powered Conversational Drug Editing Using Retrieval and Domain Feedback

Recent advancements in conversational large language models (LLMs), such as ChatGPT, have demonstrated remarkable promise in various domains, including drug discovery. However, existing works mainly focus on investigating the capabilities of conversational LLMs on chemical reaction and retrosynthesis. While drug editing, a critical task in the drug discovery pipeline, remains largely unexplored. To bridge this gap, we propose ChatDrug, a framework to facilitate the systematic investigation of drug editing using LLMs. ChatDrug jointly leverages a prompt module, a retrieval and domain feedback (ReDF) module, and a conversation module to streamline effective drug editing. We empirically show that ChatDrug reaches the best performance on 33 out of 39 drug editing tasks, encompassing small molecules, peptides, and proteins. We further demonstrate, through 10 case studies, that ChatDrug can successfully identify the key substructures (e.g., the molecule functional groups, peptide motifs, and protein structures) for manipulation, generating diverse and valid suggestions for drug editing. Promisingly, we also show that ChatDrug can offer insightful explanations from a domain-specific perspective, enhancing interpretability and enabling informed decision-making. This research sheds light on the potential of ChatGPT and conversational LLMs for drug editing. It paves the way for a more efficient and collaborative drug discovery pipeline, contributing to the advancement of pharmaceutical research and development.

ChatGPT as an Attack Tool: Stealthy Textual Backdoor Attack via Blackbox Generative Model Trigger

Textual backdoor attacks pose a practical threat to existing systems, as they can compromise the model by inserting imperceptible triggers into inputs and manipulating labels in the training dataset. With cutting-edge generative models such as GPT-4 pushing rewriting to extraordinary levels, such attacks are becoming even harder to detect. We conduct a comprehensive investigation of the role of black-box generative models as a backdoor attack tool, highlighting the importance of researching relative defense strategies. In this paper, we reveal that the proposed generative model-based attack, BGMAttack, could effectively deceive textual classifiers. Compared with the traditional attack methods, BGMAttack makes the backdoor trigger less conspicuous by leveraging state-of-the-art generative models. Our extensive evaluation of attack effectiveness across five datasets, complemented by three distinct human cognition assessments, reveals that Figure 4 achieves comparable attack performance while maintaining superior stealthiness relative to baseline methods.