From Real Artifacts to Virtual Reference: A Robust Framework for Translating Endoscopic Images

Domain adaptation, which bridges the distributions across different modalities, plays a crucial role in multimodal medical image analysis. In endoscopic imaging, combining pre-operative data with intra-operative imaging is important for surgical planning and navigation. However, existing domain adaptation methods are hampered by distribution shift caused by in vivo artifacts, necessitating robust techniques for aligning noisy and artifact abundant patient endoscopic videos with clean virtual images reconstructed from pre-operative tomographic data for pose estimation during intraoperative guidance. This paper presents an artifact-resilient image translation method and an associated benchmark for this purpose. The method incorporates a novel ``local-global'' translation framework and a noise-resilient feature extraction strategy. For the former, it decouples the image translation process into a local step for feature denoising, and a global step for global style transfer. For feature extraction, a new contrastive learning strategy is proposed, which can extract noise-resilient features for establishing robust correspondence across domains. Detailed validation on both public and in-house clinical datasets has been conducted, demonstrating significantly improved performance compared to the current state-of-the-art.

Multi-site, Multi-domain Airway Tree Modeling : A Public Benchmark for Pulmonary Airway Segmentation

Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolution. Since EXACT'09 pulmonary airway segmentation, limited effort has been directed to quantitative comparison of newly emerged algorithms driven by the maturity of deep learning based approaches and clinical drive for resolving finer details of distal airways for early intervention of pulmonary diseases. Thus far, public annotated datasets are extremely limited, hindering the development of data-driven methods and detailed performance evaluation of new algorithms. To provide a benchmark for the medical imaging community, we organized the Multi-site, Multi-domain Airway Tree Modeling (ATM'22), which was held as an official challenge event during the MICCAI 2022 conference. ATM'22 provides large-scale CT scans with detailed pulmonary airway annotation, including 500 CT scans (300 for training, 50 for validation, and 150 for testing). The dataset was collected from different sites and it further included a portion of noisy COVID-19 CTs with ground-glass opacity and consolidation. Twenty-three teams participated in the entire phase of the challenge and the algorithms for the top ten teams are reviewed in this paper. Quantitative and qualitative results revealed that deep learning models embedded with the topological continuity enhancement achieved superior performance in general. ATM'22 challenge holds as an open-call design, the training data and the gold standard evaluation are available upon successful registration via its homepage.

Shared Coupling-bridge for Weakly Supervised Local Feature Learning

Sparse local feature extraction is usually believed to be of important significance in typical vision tasks such as simultaneous localization and mapping, image matching and 3D reconstruction. At present, it still has some deficiencies needing further improvement, mainly including the discrimination power of extracted local descriptors, the localization accuracy of detected keypoints, and the efficiency of local feature learning. This paper focuses on promoting the currently popular sparse local feature learning with camera pose supervision. Therefore, it pertinently proposes a Shared Coupling-bridge scheme with four light-weight yet effective improvements for weakly-supervised local feature (SCFeat) learning. It mainly contains: i) the \emph{Feature-Fusion-ResUNet Backbone} (F2R-Backbone) for local descriptors learning, ii) a shared coupling-bridge normalization to improve the decoupling training of description network and detection network, iii) an improved detection network with peakiness measurement to detect keypoints and iv) the fundamental matrix error as a reward factor to further optimize feature detection training. Extensive experiments prove that our SCFeat improvement is effective. It could often obtain a state-of-the-art performance on classic image matching and visual localization. In terms of 3D reconstruction, it could still achieve competitive results. For sharing and communication, our source codes are available at https://github.com/sunjiayuanro/SCFeat.git.

BREAK: Bronchi Reconstruction by gEodesic transformation And sKeleton embedding

Airway segmentation is critical for virtual bronchoscopy and computer-aided pulmonary disease analysis. In recent years, convolutional neural networks (CNNs) have been widely used to delineate the bronchial tree. However, the segmentation results of the CNN-based methods usually include many discontinuous branches, which need manual repair in clinical use. A major reason for the breakages is that the appearance of the airway wall can be affected by the lung disease as well as the adjacency of the vessels, while the network tends to overfit to these special patterns in the training set. To learn robust features for these areas, we design a multi-branch framework that adopts the geodesic distance transform to capture the intensity changes between airway lumen and wall. Another reason for the breakages is the intra-class imbalance. Since the volume of the peripheral bronchi may be much smaller than the large branches in an input patch, the common segmentation loss is not sensitive to the breakages among the distal branches. Therefore, in this paper, a breakage-sensitive regularization term is designed and can be easily combined with other loss functions. Extensive experiments are conducted on publicly available datasets. Compared with state-of-the-art methods, our framework can detect more branches while maintaining competitive segmentation performance.

Alleviating Class-wise Gradient Imbalance for Pulmonary Airway Segmentation

Automated airway segmentation is a prerequisite for pre-operative diagnosis and intra-operative navigation for pulmonary intervention. Due to the small size and scattered spatial distribution of peripheral bronchi, this is hampered by severe class imbalance between foreground and background regions, which makes it challenging for CNN-based methods to parse distal small airways. In this paper, we demonstrate that this problem is arisen by gradient erosion and dilation of the neighborhood voxels. During back-propagation, if the ratio of the foreground gradient to background gradient is small while the class imbalance is local, the foreground gradients can be eroded by their neighborhoods. This process cumulatively increases the noise information included in the gradient flow from top layers to the bottom ones, limiting the learning of small structures in CNNs. To alleviate this problem, we use group supervision and the corresponding WingsNet to provide complementary gradient flows to enhance the training of shallow layers. To further address the intra-class imbalance between large and small airways, we design a General Union loss function which obviates the impact of airway size by distance-based weights and adaptively tunes the gradient ratio based on the learning process. Extensive experiments on public datasets demonstrate that the proposed method can predict the airway structures with higher accuracy and better morphological completeness.