Few-Shot Learning for Chronic Disease Management: Leveraging Large Language Models and Multi-Prompt Engineering with Medical Knowledge Injection

This study harnesses state-of-the-art AI technology for chronic disease management, specifically in detecting various mental disorders through user-generated textual content. Existing studies typically rely on fully supervised machine learning, which presents challenges such as the labor-intensive manual process of annotating extensive training data for each disease and the need to design specialized deep learning architectures for each problem. To address such challenges, we propose a novel framework that leverages advanced AI techniques, including large language models and multi-prompt engineering. Specifically, we address two key technical challenges in data-driven chronic disease management: (1) developing personalized prompts to represent each user's uniqueness and (2) incorporating medical knowledge into prompts to provide context for chronic disease detection, instruct learning objectives, and operationalize prediction goals. We evaluate our method using four mental disorders, which are prevalent chronic diseases worldwide, as research cases. On the depression detection task, our method (F1 = 0.975~0.978) significantly outperforms traditional supervised learning paradigms, including feature engineering (F1 = 0.760) and architecture engineering (F1 = 0.756). Meanwhile, our approach demonstrates success in few-shot learning, i.e., requiring only a minimal number of training examples to detect chronic diseases based on user-generated textual content (i.e., only 2, 10, or 100 subjects). Moreover, our method can be generalized to other mental disorder detection tasks, including anorexia, pathological gambling, and self-harm (F1 = 0.919~0.978).

Patient Dropout Prediction in Virtual Health: A Multimodal Dynamic Knowledge Graph and Text Mining Approach

Virtual health has been acclaimed as a transformative force in healthcare delivery. Yet, its dropout issue is critical that leads to poor health outcomes, increased health, societal, and economic costs. Timely prediction of patient dropout enables stakeholders to take proactive steps to address patients' concerns, potentially improving retention rates. In virtual health, the information asymmetries inherent in its delivery format, between different stakeholders, and across different healthcare delivery systems hinder the performance of existing predictive methods. To resolve those information asymmetries, we propose a Multimodal Dynamic Knowledge-driven Dropout Prediction (MDKDP) framework that learns implicit and explicit knowledge from doctor-patient dialogues and the dynamic and complex networks of various stakeholders in both online and offline healthcare delivery systems. We evaluate MDKDP by partnering with one of the largest virtual health platforms in China. MDKDP improves the F1-score by 3.26 percentage points relative to the best benchmark. Comprehensive robustness analyses show that integrating stakeholder attributes, knowledge dynamics, and compact bilinear pooling significantly improves the performance. Our work provides significant implications for healthcare IT by revealing the value of mining relations and knowledge across different service modalities. Practically, MDKDP offers a novel design artifact for virtual health platforms in patient dropout management.

What Symptoms and How Long? An Interpretable AI Approach for Depression Detection in Social Media

Depression is the most prevalent and serious mental illness, which induces grave financial and societal ramifications. Depression detection is key for early intervention to mitigate those consequences. Such a high-stake decision inherently necessitates interpretability, which most existing methods fall short of. To connect human expertise in this decision-making, safeguard trust from end users, and ensure algorithm transparency, we develop an interpretable deep learning model: Multi-Scale Temporal Prototype Network (MSTPNet). MSTPNet is built upon the emergent prototype learning methods. In line with the medical practice of depression diagnosis, MSTPNet differs from existing prototype learning models in its capability of capturing the depressive symptoms and their temporal distribution such as frequency and persistence of appearance. Extensive empirical analyses using real-world social media data show that MSTPNet outperforms state-of-the-art benchmarks in depression detection, with an F1-score of 0.851. Moreover, MSTPNet interprets its prediction by identifying what depression symptoms the user presents and how long these related symptoms last. We further conduct a user study to demonstrate its superiority over the benchmarks in interpretability. Methodologically, this study contributes to extant literature with a novel interpretable deep learning model for depression detection in social media. Our proposed method can be implemented in social media platforms to detect depression and its symptoms. Platforms can subsequently provide personalized online resources such as educational and supporting videos and articles, or sources for treatments and social support for depressed patients.

Depression Detection Using Digital Traces on Social Media: A Knowledge-aware Deep Learning Approach

Depression is a common disease worldwide. It is difficult to diagnose and continues to be underdiagnosed. Because depressed patients constantly share their symptoms, major life events, and treatments on social media, researchers are turning to user-generated digital traces on social media for depression detection. Such methods have distinct advantages in combating depression because they can facilitate innovative approaches to fight depression and alleviate its social and economic burden. However, most existing studies lack effective means to incorporate established medical domain knowledge in depression detection or suffer from feature extraction difficulties that impede greater performance. Following the design science research paradigm, we propose a Deep Knowledge-aware Depression Detection (DKDD) framework to accurately detect social media users at risk of depression and explain the critical factors that contribute to such detection. Extensive empirical studies with real-world data demonstrate that, by incorporating domain knowledge, our method outperforms existing state-of-the-art methods. Our work has significant implications for IS research in knowledge-aware machine learning, digital traces utilization, and NLP research in IS. Practically, by providing early detection and explaining the critical factors, DKDD can supplement clinical depression screening and enable large-scale evaluations of a population's mental health status.

Care for the Mind Amid Chronic Diseases: An Interpretable AI Approach Using IoT

Health sensing for chronic disease management creates immense benefits for social welfare. Existing health sensing studies primarily focus on the prediction of physical chronic diseases. Depression, a widespread complication of chronic diseases, is however understudied. We draw on the medical literature to support depression prediction using motion sensor data. To connect human expertise in the decision-making, safeguard trust for this high-stake prediction, and ensure algorithm transparency, we develop an interpretable deep learning model: Temporal Prototype Network (TempPNet). TempPNet is built upon the emergent prototype learning models. To accommodate the temporal characteristic of sensor data and the progressive property of depression, TempPNet differs from existing prototype learning models in its capability of capturing the temporal progression of depression. Extensive empirical analyses using real-world motion sensor data show that TempPNet outperforms state-of-the-art benchmarks in depression prediction. Moreover, TempPNet interprets its predictions by visualizing the temporal progression of depression and its corresponding symptoms detected from sensor data. We further conduct a user study to demonstrate its superiority over the benchmarks in interpretability. This study offers an algorithmic solution for impactful social good - collaborative care of chronic diseases and depression in health sensing. Methodologically, it contributes to extant literature with a novel interpretable deep learning model for depression prediction from sensor data. Patients, doctors, and caregivers can deploy our model on mobile devices to monitor patients' depression risks in real-time. Our model's interpretability also allows human experts to participate in the decision-making by reviewing the interpretation of prediction outcomes and making informed interventions.

Understanding Health Misinformation Transmission: An Interpretable Deep Learning Approach to Manage Infodemics

Health misinformation on social media devastates physical and mental health, invalidates health gains, and potentially costs lives. Understanding how health misinformation is transmitted is an urgent goal for researchers, social media platforms, health sectors, and policymakers to mitigate those ramifications. Deep learning methods have been deployed to predict the spread of misinformation. While achieving the state-of-the-art predictive performance, deep learning methods lack the interpretability due to their blackbox nature. To remedy this gap, this study proposes a novel interpretable deep learning approach, Generative Adversarial Network based Piecewise Wide and Attention Deep Learning (GAN-PiWAD), to predict health misinformation transmission in social media. Improving upon state-of-the-art interpretable methods, GAN-PiWAD captures the interactions among multi-modal data, offers unbiased estimation of the total effect of each feature, and models the dynamic total effect of each feature when its value varies. We select features according to social exchange theory and evaluate GAN-PiWAD on 4,445 misinformation videos. The proposed approach outperformed strong benchmarks. Interpretation of GAN-PiWAD indicates video description, negative video content, and channel credibility are key features that drive viral transmission of misinformation. This study contributes to IS with a novel interpretable deep learning method that is generalizable to understand other human decision factors. Our findings provide direct implications for social media platforms and policymakers to design proactive interventions to identify misinformation, control transmissions, and manage infodemics.