Mix, Align, Distil: Reliable Cross-Domain Atypical Mitosis Classification

Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple training-time recipe for domain-robust AMF classification in MIDOG 2025 Task 2. The approach (i) increases feature diversity via style perturbations inserted at early and mid backbone stages, (ii) aligns attention-refined features across sites using weak domain labels (Scanner, Origin, Species, Tumor) through an auxiliary alignment loss, and (iii) stabilizes predictions by distilling from an exponential moving average (EMA) teacher with temperature-scaled KL divergence. On the organizer-run preliminary leaderboard for atypical mitosis classification, our submission attains balanced accuracy of 0.8762, sensitivity of 0.8873, specificity of 0.8651, and ROC AUC of 0.9499. The method incurs negligible inference-time overhead, relies only on coarse domain metadata, and delivers strong, balanced performance, positioning it as a competitive submission for the MIDOG 2025 challenge.

Federated Cross-Modal Style-Aware Prompt Generation

Prompt learning has propelled vision-language models like CLIP to excel in diverse tasks, making them ideal for federated learning due to computational efficiency. However, conventional approaches that rely solely on final-layer features miss out on rich multi-scale visual cues and domain-specific style variations in decentralized client data. To bridge this gap, we introduce FedCSAP (Federated Cross-Modal Style-Aware Prompt Generation). Our framework harnesses low, mid, and high-level features from CLIP's vision encoder alongside client-specific style indicators derived from batch-level statistics. By merging intricate visual details with textual context, FedCSAP produces robust, context-aware prompt tokens that are both distinct and non-redundant, thereby boosting generalization across seen and unseen classes. Operating within a federated learning paradigm, our approach ensures data privacy through local training and global aggregation, adeptly handling non-IID class distributions and diverse domain-specific styles. Comprehensive experiments on multiple image classification datasets confirm that FedCSAP outperforms existing federated prompt learning methods in both accuracy and overall generalization.

Survival Modeling from Whole Slide Images via Patch-Level Graph Clustering and Mixture Density Experts

We introduce a modular framework for predicting cancer-specific survival from whole slide pathology images (WSIs) that significantly improves upon the state-of-the-art accuracy. Our method integrating four key components. Firstly, to tackle large size of WSIs, we use dynamic patch selection via quantile-based thresholding for isolating prognostically informative tissue regions. Secondly, we use graph-guided k-means clustering to capture phenotype-level heterogeneity through spatial and morphological coherence. Thirdly, we use attention mechanisms that model both intra- and inter-cluster relationships to contextualize local features within global spatial relations between various types of tissue compartments. Finally, we use an expert-guided mixture density modeling for estimating complex survival distributions using Gaussian mixture models. The proposed model achieves a concordance index of $0.712 \pm 0.028$ and Brier score of $0.254 \pm 0.018$ on TCGA-KIRC (renal cancer), and a concordance index of $0.645 \pm 0.017$ and Brier score of $0.281 \pm 0.031$ on TCGA-LUAD (lung adenocarcinoma). These results are significantly better than the state-of-art and demonstrate predictive potential of the proposed method across diverse cancer types.

Predicting Genetic Mutations from Single-Cell Bone Marrow Images in Acute Myeloid Leukemia Using Noise-Robust Deep Learning Models

In this study, we propose a robust methodology for identification of myeloid blasts followed by prediction of genetic mutation in single-cell images of blasts, tackling challenges associated with label accuracy and data noise. We trained an initial binary classifier to distinguish between leukemic (blasts) and non-leukemic cells images, achieving 90 percent accuracy. To evaluate the models generalization, we applied this model to a separate large unlabeled dataset and validated the predictions with two haemato-pathologists, finding an approximate error rate of 20 percent in the leukemic and non-leukemic labels. Assuming this level of label noise, we further trained a four-class model on images predicted as blasts to classify specific mutations. The mutation labels were known for only a bag of cell images extracted from a single slide. Despite the tumor label noise, our mutation classification model achieved 85 percent accuracy across four mutation classes, demonstrating resilience to label inconsistencies. This study highlights the capability of machine learning models to work with noisy labels effectively while providing accurate, clinically relevant mutation predictions, which is promising for diagnostic applications in areas such as haemato-pathology.

A Cytology Dataset for Early Detection of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma OSCC is a major global health burden, particularly in several regions across Asia, Africa, and South America, where it accounts for a significant proportion of cancer cases. Early detection dramatically improves outcomes, with stage I cancers achieving up to 90 percent survival. However, traditional diagnosis based on histopathology has limited accessibility in low-resource settings because it is invasive, resource-intensive, and reliant on expert pathologists. On the other hand, oral cytology of brush biopsy offers a minimally invasive and lower cost alternative, provided that the remaining challenges, inter observer variability and unavailability of expert pathologists can be addressed using artificial intelligence. Development and validation of robust AI solutions requires access to large, labeled, and multi-source datasets to train high capacity models that generalize across domain shifts. We introduce the first large and multicenter oral cytology dataset, comprising annotated slides stained with Papanicolaou(PAP) and May-Grunwald-Giemsa(MGG) protocols, collected from ten tertiary medical centers in India. The dataset is labeled and annotated by expert pathologists for cellular anomaly classification and detection, is designed to advance AI driven diagnostic methods. By filling the gap in publicly available oral cytology datasets, this resource aims to enhance automated detection, reduce diagnostic errors, and improve early OSCC diagnosis in resource-constrained settings, ultimately contributing to reduced mortality and better patient outcomes worldwide.

FEDTAIL: Federated Long-Tailed Domain Generalization with Sharpness-Guided Gradient Matching

Domain Generalization (DG) seeks to train models that perform reliably on unseen target domains without access to target data during training. While recent progress in smoothing the loss landscape has improved generalization, existing methods often falter under long-tailed class distributions and conflicting optimization objectives. We introduce FedTAIL, a federated domain generalization framework that explicitly addresses these challenges through sharpness-guided, gradient-aligned optimization. Our method incorporates a gradient coherence regularizer to mitigate conflicts between classification and adversarial objectives, leading to more stable convergence. To combat class imbalance, we perform class-wise sharpness minimization and propose a curvature-aware dynamic weighting scheme that adaptively emphasizes underrepresented tail classes. Furthermore, we enhance conditional distribution alignment by integrating sharpness-aware perturbations into entropy regularization, improving robustness under domain shift. FedTAIL unifies optimization harmonization, class-aware regularization, and conditional alignment into a scalable, federated-compatible framework. Extensive evaluations across standard domain generalization benchmarks demonstrate that FedTAIL achieves state-of-the-art performance, particularly in the presence of domain shifts and label imbalance, validating its effectiveness in both centralized and federated settings. Code: https://github.com/sunnyinAI/FedTail

UniVarFL: Uniformity and Variance Regularized Federated Learning for Heterogeneous Data

Federated Learning (FL) often suffers from severe performance degradation when faced with non-IID data, largely due to local classifier bias. Traditional remedies such as global model regularization or layer freezing either incur high computational costs or struggle to adapt to feature shifts. In this work, we propose UniVarFL, a novel FL framework that emulates IID-like training dynamics directly at the client level, eliminating the need for global model dependency. UniVarFL leverages two complementary regularization strategies during local training: Classifier Variance Regularization, which aligns class-wise probability distributions with those expected under IID conditions, effectively mitigating local classifier bias; and Hyperspherical Uniformity Regularization, which encourages a uniform distribution of feature representations across the hypersphere, thereby enhancing the model's ability to generalize under diverse data distributions. Extensive experiments on multiple benchmark datasets demonstrate that UniVarFL outperforms existing methods in accuracy, highlighting its potential as a highly scalable and efficient solution for real-world FL deployments, especially in resource-constrained settings. Code: https://github.com/sunnyinAI/UniVarFL

FANVID: A Benchmark for Face and License Plate Recognition in Low-Resolution Videos

Real-world surveillance often renders faces and license plates unrecognizable in individual low-resolution (LR) frames, hindering reliable identification. To advance temporal recognition models, we present FANVID, a novel video-based benchmark comprising nearly 1,463 LR clips (180 x 320, 20--60 FPS) featuring 63 identities and 49 license plates from three English-speaking countries. Each video includes distractor faces and plates, increasing task difficulty and realism. The dataset contains 31,096 manually verified bounding boxes and labels. FANVID defines two tasks: (1) face matching -- detecting LR faces and matching them to high-resolution mugshots, and (2) license plate recognition -- extracting text from LR plates without a predefined database. Videos are downsampled from high-resolution sources to ensure that faces and text are indecipherable in single frames, requiring models to exploit temporal information. We introduce evaluation metrics adapted from mean Average Precision at IoU > 0.5, prioritizing identity correctness for faces and character-level accuracy for text. A baseline method with pre-trained video super-resolution, detection, and recognition achieved performance scores of 0.58 (face matching) and 0.42 (plate recognition), highlighting both the feasibility and challenge of the tasks. FANVID's selection of faces and plates balances diversity with recognition challenge. We release the software for data access, evaluation, baseline, and annotation to support reproducibility and extension. FANVID aims to catalyze innovation in temporal modeling for LR recognition, with applications in surveillance, forensics, and autonomous vehicles.

Network Inversion for Uncertainty-Aware Out-of-Distribution Detection

Out-of-distribution (OOD) detection and uncertainty estimation (UE) are critical components for building safe machine learning systems, especially in real-world scenarios where unexpected inputs are inevitable. In this work, we propose a novel framework that combines network inversion with classifier training to simultaneously address both OOD detection and uncertainty estimation. For a standard n-class classification task, we extend the classifier to an (n+1)-class model by introducing a "garbage" class, initially populated with random gaussian noise to represent outlier inputs. After each training epoch, we use network inversion to reconstruct input images corresponding to all output classes that initially appear as noisy and incoherent and are therefore excluded to the garbage class for retraining the classifier. This cycle of training, inversion, and exclusion continues iteratively till the inverted samples begin to resemble the in-distribution data more closely, suggesting that the classifier has learned to carve out meaningful decision boundaries while sanitising the class manifolds by pushing OOD content into the garbage class. During inference, this training scheme enables the model to effectively detect and reject OOD samples by classifying them into the garbage class. Furthermore, the confidence scores associated with each prediction can be used to estimate uncertainty for both in-distribution and OOD inputs. Our approach is scalable, interpretable, and does not require access to external OOD datasets or post-hoc calibration techniques while providing a unified solution to the dual challenges of OOD detection and uncertainty estimation.

A Surrogate Model for the Forward Design of Multi-layered Metasurface-based Radar Absorbing Structures

Metasurface-based radar absorbing structures (RAS) are highly preferred for applications like stealth technology, electromagnetic (EM) shielding, etc. due to their capability to achieve frequency selective absorption characteristics with minimal thickness and reduced weight penalty. However, the conventional approach for the EM design and optimization of these structures relies on forward simulations, using full wave simulation tools, to predict the electromagnetic (EM) response of candidate meta atoms. This process is computationally intensive, extremely time consuming and requires exploration of large design spaces. To overcome this challenge, we propose a surrogate model that significantly accelerates the prediction of EM responses of multi-layered metasurface-based RAS. A convolutional neural network (CNN) based architecture with Huber loss function has been employed to estimate the reflection characteristics of the RAS model. The proposed model achieved a cosine similarity of 99.9% and a mean square error of 0.001 within 1000 epochs of training. The efficiency of the model has been established via full wave simulations as well as experiment where it demonstrated significant reduction in computational time while maintaining high predictive accuracy.