Improving Brain Disorder Diagnosis with Advanced Brain Function Representation and Kolmogorov-Arnold Networks

Quantifying functional connectivity (FC), a vital metric for the diagnosis of various brain disorders, traditionally relies on the use of a pre-defined brain atlas. However, using such atlases can lead to issues regarding selection bias and lack of regard for specificity. Addressing this, we propose a novel transformer-based classification network (AFBR-KAN) with effective brain function representation to aid in diagnosing autism spectrum disorder (ASD). AFBR-KAN leverages Kolmogorov-Arnold Network (KAN) blocks replacing traditional multi-layer perceptron (MLP) components. Thorough experimentation reveals the effectiveness of AFBR-KAN in improving the diagnosis of ASD under various configurations of the model architecture. Our code is available at https://github.com/tbwa233/ABFR-KAN

Prompting Medical Vision-Language Models to Mitigate Diagnosis Bias by Generating Realistic Dermoscopic Images

Artificial Intelligence (AI) in skin disease diagnosis has improved significantly, but a major concern is that these models frequently show biased performance across subgroups, especially regarding sensitive attributes such as skin color. To address these issues, we propose a novel generative AI-based framework, namely, Dermatology Diffusion Transformer (DermDiT), which leverages text prompts generated via Vision Language Models and multimodal text-image learning to generate new dermoscopic images. We utilize large vision language models to generate accurate and proper prompts for each dermoscopic image which helps to generate synthetic images to improve the representation of underrepresented groups (patient, disease, etc.) in highly imbalanced datasets for clinical diagnoses. Our extensive experimentation showcases the large vision language models providing much more insightful representations, that enable DermDiT to generate high-quality images. Our code is available at https://github.com/Munia03/DermDiT

EarthScape: A Multimodal Dataset for Surficial Geologic Mapping and Earth Surface Analysis

Surficial geologic mapping is essential for understanding Earth surface processes, addressing modern challenges such as climate change and national security, and supporting common applications in engineering and resource management. However, traditional mapping methods are labor-intensive, limiting spatial coverage and introducing potential biases. To address these limitations, we introduce EarthScape, a novel, AI-ready multimodal dataset specifically designed for surficial geologic mapping and Earth surface analysis. EarthScape integrates high-resolution aerial RGB and near-infrared (NIR) imagery, digital elevation models (DEM), multi-scale DEM-derived terrain features, and hydrologic and infrastructure vector data. The dataset provides detailed annotations for seven distinct surficial geologic classes encompassing various geological processes. We present a comprehensive data processing pipeline using open-sourced raw data and establish baseline benchmarks using different spatial modalities to demonstrate the utility of EarthScape. As a living dataset with a vision for expansion, EarthScape bridges the gap between computer vision and Earth sciences, offering a valuable resource for advancing research in multimodal learning, geospatial analysis, and geological mapping. Our code is available at https://github.com/masseygeo/earthscape.

Annotation-Efficient Task Guidance for Medical Segment Anything

Medical image segmentation is a key task in the imaging workflow, influencing many image-based decisions. Traditional, fully-supervised segmentation models rely on large amounts of labeled training data, typically obtained through manual annotation, which can be an expensive, time-consuming, and error-prone process. This signals a need for accurate, automatic, and annotation-efficient methods of training these models. We propose SAM-Mix, a novel multitask learning framework for medical image segmentation that uses class activation maps produced by an auxiliary classifier to guide the predictions of the semi-supervised segmentation branch, which is based on the SAM framework. Experimental evaluations on the public LiTS dataset confirm the effectiveness of SAM-Mix for simultaneous classification and segmentation of the liver from abdominal computed tomography (CT) scans. When trained for 90% fewer epochs on only 50 labeled 2D slices, representing just 0.04% of the available labeled training data, SAM-Mix achieves a Dice improvement of 5.1% over the best baseline model. The generalization results for SAM-Mix are even more impressive, with the same model configuration yielding a 25.4% Dice improvement on a cross-domain segmentation task. Our code is available at https://github.com/tbwa233/SAM-Mix.

Scout-Net: Prospective Personalized Estimation of CT Organ Doses from Scout Views

Purpose: Estimation of patient-specific organ doses is required for more comprehensive dose metrics, such as effective dose. Currently, available methods are performed retrospectively using the CT images themselves, which can only be done after the scan. To optimize CT acquisitions before scanning, rapid prediction of patient-specific organ dose is needed prospectively, using available scout images. We, therefore, devise an end-to-end, fully-automated deep learning solution to perform real-time, patient-specific, organ-level dosimetric estimation of CT scans. Approach: We propose the Scout-Net model for CT dose prediction at six different organs as well as for the overall patient body, leveraging the routinely obtained frontal and lateral scout images of patients, before their CT scans. To obtain reference values of the organ doses, we used Monte Carlo simulation and 3D segmentation methods on the corresponding CT images of the patients. Results: We validate our proposed Scout-Net model against real patient CT data and demonstrate the effectiveness in estimating organ doses in real-time (only 27 ms on average per scan). Additionally, we demonstrate the efficiency (real-time execution), sufficiency (reasonable error rates), and robustness (consistent across varying patient sizes) of the Scout-Net model. Conclusions: An effective, efficient, and robust Scout-Net model, once incorporated into the CT acquisition plan, could potentially guide the automatic exposure control for balanced image quality and radiation dose.

Forward-Forward Contrastive Learning

Medical image classification is one of the most important tasks for computer-aided diagnosis. Deep learning models, particularly convolutional neural networks, have been successfully used for disease classification from medical images, facilitated by automated feature learning. However, the diverse imaging modalities and clinical pathology make it challenging to construct generalized and robust classifications. Towards improving the model performance, we propose a novel pretraining approach, namely Forward Forward Contrastive Learning (FFCL), which leverages the Forward-Forward Algorithm in a contrastive learning framework--both locally and globally. Our experimental results on the chest X-ray dataset indicate that the proposed FFCL achieves superior performance (3.69% accuracy over ImageNet pretrained ResNet-18) over existing pretraining models in the pneumonia classification task. Moreover, extensive ablation experiments support the particular local and global contrastive pretraining design in FFCL.

Semi-Supervised Relational Contrastive Learning

Disease diagnosis from medical images via supervised learning is usually dependent on tedious, error-prone, and costly image labeling by medical experts. Alternatively, semi-supervised learning and self-supervised learning offer effectiveness through the acquisition of valuable insights from readily available unlabeled images. We present Semi-Supervised Relational Contrastive Learning (SRCL), a novel semi-supervised learning model that leverages self-supervised contrastive loss and sample relation consistency for the more meaningful and effective exploitation of unlabeled data. Our experimentation with the SRCL model explores both pre-train/fine-tune and joint learning of the pretext (contrastive learning) and downstream (diagnostic classification) tasks. We validate against the ISIC 2018 Challenge benchmark skin lesion classification dataset and demonstrate the effectiveness of our semi-supervised method on varying amounts of labeled data.

Single Image Internal Distribution Measurement Using Non-Local Variational Autoencoder

Deep learning-based super-resolution methods have shown great promise, especially for single image super-resolution (SISR) tasks. Despite the performance gain, these methods are limited due to their reliance on copious data for model training. In addition, supervised SISR solutions rely on local neighbourhood information focusing only on the feature learning processes for the reconstruction of low-dimensional images. Moreover, they fail to capitalize on global context due to their constrained receptive field. To combat these challenges, this paper proposes a novel image-specific solution, namely non-local variational autoencoder (\texttt{NLVAE}), to reconstruct a high-resolution (HR) image from a single low-resolution (LR) image without the need for any prior training. To harvest maximum details for various receptive regions and high-quality synthetic images, \texttt{NLVAE} is introduced as a self-supervised strategy that reconstructs high-resolution images using disentangled information from the non-local neighbourhood. Experimental results from seven benchmark datasets demonstrate the effectiveness of the \texttt{NLVAE} model. Moreover, our proposed model outperforms a number of baseline and state-of-the-art methods as confirmed through extensive qualitative and quantitative evaluations.

Generalized Multi-Task Learning from Substantially Unlabeled Multi-Source Medical Image Data

Deep learning-based models, when trained in a fully-supervised manner, can be effective in performing complex image analysis tasks, although contingent upon the availability of large labeled datasets. Especially in the medical imaging domain, however, expert image annotation is expensive, time-consuming, and prone to variability. Semi-supervised learning from limited quantities of labeled data has shown promise as an alternative. Maximizing knowledge gains from copious unlabeled data benefits semi-supervised learning models. Moreover, learning multiple tasks within the same model further improves its generalizability. We propose MultiMix, a new multi-task learning model that jointly learns disease classification and anatomical segmentation in a semi-supervised manner, while preserving explainability through a novel saliency bridge between the two tasks. Our experiments with varying quantities of multi-source labeled data in the training sets confirm the effectiveness of MultiMix in the simultaneous classification of pneumonia and segmentation of the lungs in chest X-ray images. Moreover, both in-domain and cross-domain evaluations across these tasks further showcase the potential of our model to adapt to challenging generalization scenarios.

Window-Level is a Strong Denoising Surrogate

CT image quality is heavily reliant on radiation dose, which causes a trade-off between radiation dose and image quality that affects the subsequent image-based diagnostic performance. However, high radiation can be harmful to both patients and operators. Several (deep learning-based) approaches have been attempted to denoise low dose images. However, those approaches require access to large training sets, specifically the full dose CT images for reference, which can often be difficult to obtain. Self-supervised learning is an emerging alternative for lowering the reference data requirement facilitating unsupervised learning. Currently available self-supervised CT denoising works are either dependent on foreign domain or pretexts are not very task-relevant. To tackle the aforementioned challenges, we propose a novel self-supervised learning approach, namely Self-Supervised Window-Leveling for Image DeNoising (SSWL-IDN), leveraging an innovative, task-relevant, simple, yet effective surrogate -- prediction of the window-leveled equivalent. SSWL-IDN leverages residual learning and a hybrid loss combining perceptual loss and MSE, all incorporated in a VAE framework. Our extensive (in- and cross-domain) experimentation demonstrates the effectiveness of SSWL-IDN in aggressive denoising of CT (abdomen and chest) images acquired at 5\% dose level only.