AutoMedPrompt: A New Framework for Optimizing LLM Medical Prompts Using Textual Gradients

Large language models (LLMs) have demonstrated increasingly sophisticated performance in medical and other fields of knowledge. Traditional methods of creating specialist LLMs require extensive fine-tuning and training of models on large datasets. Recently, prompt engineering, instead of fine-tuning, has shown potential to boost the performance of general foundation models. However, prompting methods such as chain-of-thought (CoT) may not be suitable for all subspecialty, and k-shot approaches may introduce irrelevant tokens into the context space. We present AutoMedPrompt, which explores the use of textual gradients to elicit medically relevant reasoning through system prompt optimization. AutoMedPrompt leverages TextGrad's automatic differentiation via text to improve the ability of general foundation LLMs. We evaluated AutoMedPrompt on Llama 3, an open-source LLM, using several QA benchmarks, including MedQA, PubMedQA, and the nephrology subspecialty-specific NephSAP. Our results show that prompting with textual gradients outperforms previous methods on open-source LLMs and surpasses proprietary models such as GPT-4, Claude 3 Opus, and Med-PaLM 2. AutoMedPrompt sets a new state-of-the-art (SOTA) performance on PubMedQA with an accuracy of 82.6$\%$, while also outperforming previous prompting strategies on open-sourced models for MedQA (77.7$\%$) and NephSAP (63.8$\%$).

PBR-NeRF: Inverse Rendering with Physics-Based Neural Fields

We tackle the ill-posed inverse rendering problem in 3D reconstruction with a Neural Radiance Field (NeRF) approach informed by Physics-Based Rendering (PBR) theory, named PBR-NeRF. Our method addresses a key limitation in most NeRF and 3D Gaussian Splatting approaches: they estimate view-dependent appearance without modeling scene materials and illumination. To address this limitation, we present an inverse rendering (IR) model capable of jointly estimating scene geometry, materials, and illumination. Our model builds upon recent NeRF-based IR approaches, but crucially introduces two novel physics-based priors that better constrain the IR estimation. Our priors are rigorously formulated as intuitive loss terms and achieve state-of-the-art material estimation without compromising novel view synthesis quality. Our method is easily adaptable to other inverse rendering and 3D reconstruction frameworks that require material estimation. We demonstrate the importance of extending current neural rendering approaches to fully model scene properties beyond geometry and view-dependent appearance. Code is publicly available at https://github.com/s3anwu/pbrnerf

Self-supervised denoising of visual field data improves detection of glaucoma progression

Perimetric measurements provide insight into a patient's peripheral vision and day-to-day functioning and are the main outcome measure for identifying progression of visual damage from glaucoma. However, visual field data can be noisy, exhibiting high variance, especially with increasing damage. In this study, we demonstrate the utility of self-supervised deep learning in denoising visual field data from over 4000 patients to enhance its signal-to-noise ratio and its ability to detect true glaucoma progression. We deployed both a variational autoencoder (VAE) and a masked autoencoder to determine which self-supervised model best smooths the visual field data while reconstructing salient features that are less noisy and more predictive of worsening disease. Our results indicate that including a categorical p-value at every visual field location improves the smoothing of visual field data. Masked autoencoders led to cleaner denoised data than previous methods, such as variational autoencoders. A 4.7% increase in detection of progressing eyes with pointwise linear regression (PLR) was observed. The masked and variational autoencoders' smoothed data predicted glaucoma progression 2.3 months earlier when p-values were included compared to when they were not. The faster prediction of time to progression (TTP) and the higher percentage progression detected support our hypothesis that masking out visual field elements during training while including p-values at each location would improve the task of detection of visual field progression. Our study has clinically relevant implications regarding masking when training neural networks to denoise visual field data, resulting in earlier and more accurate detection of glaucoma progression. This denoising model can be integrated into future models for visual field analysis to enhance detection of glaucoma progression.

Interpolated-MLPs: Controllable Inductive Bias

Due to their weak inductive bias, Multi-Layer Perceptrons (MLPs) have subpar performance at low-compute levels compared to standard architectures such as convolution-based networks (CNN). Recent work, however, has shown that the performance gap drastically reduces as the amount of compute is increased without changing the amount of inductive bias. In this work, we study the converse: in the low-compute regime, how does the incremental increase of inductive bias affect performance? To quantify inductive bias, we propose a "soft MLP" approach, which we coin Interpolated MLP (I-MLP). We control the amount of inductive bias in the standard MLP by introducing a novel algorithm based on interpolation between fixed weights from a prior model with high inductive bias. We showcase our method using various prior models, including CNNs and the MLP-Mixer architecture. This interpolation scheme allows fractional control of inductive bias, which may be attractive when full inductive bias is not desired (e.g. in the mid-compute regime). We find experimentally that for Vision Tasks in the low-compute regime, there is a continuous and two-sided logarithmic relationship between inductive bias and performance when using CNN and MLP-Mixer prior models.

Adversarial Databases Improve Success in Retrieval-based Large Language Models

Open-source LLMs have shown great potential as fine-tuned chatbots, and demonstrate robust abilities in reasoning and surpass many existing benchmarks. Retrieval-Augmented Generation (RAG) is a technique for improving the performance of LLMs on tasks that the models weren't explicitly trained on, by leveraging external knowledge databases. Numerous studies have demonstrated the effectiveness of RAG to more successfully accomplish downstream tasks when using vector datasets that consist of relevant background information. It has been implicitly assumed by those in the field that if adversarial background information is utilized in this context, that the success of using a RAG-based approach would be nonexistent or even negatively impact the results. To address this assumption, we tested several open-source LLMs on the ability of RAG to improve their success in answering multiple-choice questions (MCQ) in the medical subspecialty field of Nephrology. Unlike previous studies, we examined the effect of RAG in utilizing both relevant and adversarial background databases. We set up several open-source LLMs, including Llama 3, Phi-3, Mixtral 8x7b, Zephyr$\beta$, and Gemma 7B Instruct, in a zero-shot RAG pipeline. As adversarial sources of information, text from the Bible and a Random Words generated database were used for comparison. Our data show that most of the open-source LLMs improve their multiple-choice test-taking success as expected when incorporating relevant information vector databases. Surprisingly however, adversarial Bible text significantly improved the success of many LLMs and even random word text improved test taking ability of some of the models. In summary, our results demonstrate for the first time the countertintuitive ability of adversarial information datasets to improve the RAG-based LLM success.

Predicting Outcomes in Video Games with Long Short Term Memory Networks

Forecasting winners in E-sports with real-time analytics has the potential to further engage audiences watching major tournament events. However, making such real-time predictions is challenging due to unpredictable variables within the game involving diverse player strategies and decision-making. Our work attempts to enhance audience engagement within video game tournaments by introducing a real-time method of predicting wins. Our Long Short Term Memory Network (LSTMs) based approach enables efficient predictions of win-lose outcomes by only using the health indicator of each player as a time series. As a proof of concept, we evaluate our model's performance within a classic, two-player arcade game, Super Street Fighter II Turbo. We also benchmark our method against state of the art methods for time series forecasting; i.e. Transformer models found in large language models (LLMs). Finally, we open-source our data set and code in hopes of furthering work in predictive analysis for arcade games.

A Comparative Study of Open-Source Large Language Models, GPT-4 and Claude 2: Multiple-Choice Test Taking in Nephrology

In recent years, there have been significant breakthroughs in the field of natural language processing, particularly with the development of large language models (LLMs). These LLMs have showcased remarkable capabilities on various benchmarks. In the healthcare field, the exact role LLMs and other future AI models will play remains unclear. There is a potential for these models in the future to be used as part of adaptive physician training, medical co-pilot applications, and digital patient interaction scenarios. The ability of AI models to participate in medical training and patient care will depend in part on their mastery of the knowledge content of specific medical fields. This study investigated the medical knowledge capability of LLMs, specifically in the context of internal medicine subspecialty multiple-choice test-taking ability. We compared the performance of several open-source LLMs (Koala 7B, Falcon 7B, Stable-Vicuna 13B, and Orca Mini 13B), to GPT-4 and Claude 2 on multiple-choice questions in the field of Nephrology. Nephrology was chosen as an example of a particularly conceptually complex subspecialty field within internal medicine. The study was conducted to evaluate the ability of LLM models to provide correct answers to nephSAP (Nephrology Self-Assessment Program) multiple-choice questions. The overall success of open-sourced LLMs in answering the 858 nephSAP multiple-choice questions correctly was 17.1% - 25.5%. In contrast, Claude 2 answered 54.4% of the questions correctly, whereas GPT-4 achieved a score of 73.3%. We show that current widely used open-sourced LLMs do poorly in their ability for zero-shot reasoning when compared to GPT-4 and Claude 2. The findings of this study potentially have significant implications for the future of subspecialty medical training and patient care.

aUToLights: A Robust Multi-Camera Traffic Light Detection and Tracking System

Following four successful years in the SAE AutoDrive Challenge Series I, the University of Toronto is participating in the Series II competition to develop a Level 4 autonomous passenger vehicle capable of handling various urban driving scenarios by 2025. Accurate detection of traffic lights and correct identification of their states is essential for safe autonomous operation in cities. Herein, we describe our recently-redesigned traffic light perception system for autonomous vehicles like the University of Toronto's self-driving car, Artemis. Similar to most traffic light perception systems, we rely primarily on camera-based object detectors. We deploy the YOLOv5 detector for bounding box regression and traffic light classification across multiple cameras and fuse the observations. To improve robustness, we incorporate priors from high-definition semantic maps and perform state filtering using hidden Markov models. We demonstrate a multi-camera, real time-capable traffic light perception pipeline that handles complex situations including multiple visible intersections, traffic light variations, temporary occlusion, and flashing light states. To validate our system, we collected and annotated a varied dataset incorporating flashing states and a range of occlusion types. Our results show superior performance in challenging real-world scenarios compared to single-frame, single-camera object detection.