Physical Limits of Proximal Tumor Detection via MAGE-A Extracellular Vesicles

Early cancer detection relies on invasive tissue biopsies or liquid biopsies limited by biomarker dilution. In contrast, tumour-derived extracellular vesicles (EVs) carrying biomarkers like melanoma-associated antigen-A (MAGE-A) are highly concentrated in the peri-tumoral interstitial space, offering a promising near-field target. However, at micrometre scales, EV transport is governed by stochastic diffusion in a low copy number regime, increasing the risk of false negatives. We theoretically assess the feasibility of a smart-needle sensor detecting MAGE-A-positive microvesicles near a tumour. We use a hybrid framework combining particle-based Brownian dynamics (Smoldyn) to quantify stochastic arrival and false negative probabilities, and a reaction-diffusion PDE for mean concentration profiles. Formulating detection as a threshold-based binary hypothesis test, we find a maximum feasible detection radius of approximately 275 micrometers for a 6000 s sensing window. These results outline the physical limits of proximal EV-based detection and inform the design of minimally invasive peri-tumoral sensors.

Environment-to-Link ISAC with Space-Weather Sensing for Ka-Band LEO Downlinks

Ka-band low-Earth-orbit (LEO) downlinks can suffer second-scale reliability collapses during flare-driven ionospheric disturbances, where fixed fade margins and reactive adaptive coding and modulation (ACM) are either overly conservative or too slow. This paper presents a GNSS-free, link-internal predictive controller that senses the same downlink via a geometry-free dual-carrier phase observable at 10~Hz: a high-pass filter and template-based onset detector, followed by a four-state nearly-constant-velocity Kalman filter, estimate $Δ$VTEC and its rate, and a short look-ahead (60~s) yields an endpoint outage probability used as a risk gate to trigger one-step discrete MCS down-switch and pilot-time update with hysteresis. Evaluation uses physics-informed log replay driven by real GOES X-ray flare morphologies under a disjoint-day frozen-calibration protocol, with uncertainty reported via paired moving-block bootstrap. Across stressed 60~s windows, the controller reduces peak BLER by 25--30\% and increases goodput by 0.10--0.15~bps/Hz versus no-adaptation baselines under a unified link-level abstraction. The loop runs in $\mathcal{O}(1)$ per 0.1~s epoch (about 0.042~ms measured), making on-board implementation feasible, and scope and deployment considerations for dispersion-dominated events are discussed.

Performance Limits of Hardware-Constrained THz Inter-Satellite MIMO-ISAC Systems

Terahertz inter-satellite links (THz-ISL) offer unprecedented bandwidth for future space networks but face fundamental constraints from onboard power and thermal budgets. This paper establishes theoretical performance limits for MIMO Integrated Sensing and Communication (ISAC) systems under per-element constant-envelope (CE) transmission constraints. We demonstrate that hardware distortions -- specifically power amplifier nonlinearity, ADC quantization, and oscillator phase noise -- impose a capacity ceiling that cannot be overcome by increasing transmit power. A unified link budget framework integrates wideband beam squint, aperture pointing errors, and colored noise sources through a spectral consistency principle that ensures residual phase noise is counted exactly once across communication and sensing analyses. The sensing bounds are derived via the Whittle-Fisher Information Matrix under a Constant Acceleration kinematic model with jerk noise, yielding closed-form scaling laws: residual phase noise variance scales as $α^{-1}$ while dynamic state-estimation error (DSE) variance scales as $α^{-5}$ with pilot overhead $α$. Numerical results show divergent MIMO scaling: sensing precision improves with array size ($\mathrm{RMSE} \propto 1/\sqrt{N_t N_r}$), while the critical SNR exhibits scale invariance regarding array size, implying that the distortion-limited transition point stabilizes regardless of the array scale. The steep $α^{-5}$ DSE scaling creates an operationally infeasible region at $α< α^* \approx 0.16$, where $α^* = (C_{\mathrm{DSE}}/C_{\mathrm{PN}})^{1/4}$ -- a constraint-driven threshold under the adopted baseline for LEO operation. These findings provide design guidelines for hardware-efficient THz-ISL constellations.

Modeling and Analysis of VOC-based Interplant Molecular Communication Channel

Molecular communication (MC) enables information transfer using particles inspired by biological systems. Volatile Organic Compounds (VOCs) are one of the most abundant and diverse classes of signaling molecules used by living or non-living objects. VOC-based MC holds great promise in developing long-range, bio-compatible communication systems capable of interfacing nano- and micro-scale devices. In this paper, we present a comprehensive end-to-end framework for VOC-based interplant MC from an ICT perspective. The communication process is divided into three stages: transmission (VOC biosynthesis and emission from leaves), channel propagation (advection-diffusion in turbulent wind via Gaussian puff for stress-induced VOC release and Gaussian plume for constitutive VOC release), and reception (VOC uptake and physiological response in the receiver plant). Each stage is analyzed by its attenuation and delay. Numerical results demonstrate that VOC-based channels exhibit low-pass behavior, with bandwidth and capacity heavily influenced by distance, wind velocity, and noise. Though the physical channel supports moderate frequencies, biological constraints at the transmitter restrict the end-to-end channel to slow-varying signals.

Graph Representation-based Model Poisoning on the Heterogeneous Internet of Agents

Internet of Agents (IoA) envisions a unified, agent-centric paradigm where heterogeneous large language model (LLM) agents can interconnect and collaborate at scale. Within this paradigm, federated learning (FL) serves as a key enabler that allows distributed LLM agents to co-train global models without centralizing data. However, the FL-enabled IoA system remains vulnerable to model poisoning attacks, and the prevailing distance and similarity-based defenses become fragile at billion-parameter scale and under heterogeneous data distributions. This paper proposes a graph representation-based model poisoning (GRMP) attack, which passively exploits observed benign local models to construct a parameter correlation graph and extends an adversarial variational graph autoencoder to capture and reshape higher-order dependencies. The GRMP attack synthesizes malicious local models that preserve benign-like statistics while embedding adversarial objectives, remaining elusive to detection at the server. Experiments demonstrate a gradual drop in system accuracy under the proposed attack and the ineffectiveness of the prevailing defense mechanism in detecting the attack, underscoring a severe threat to the ambitious IoA paradigm.

Fundamental Limits of Cooperative Integrated Sensing and Communications over Low-Earth Orbit THz Satellite Channels

Terahertz inter-satellite links enable unprecedented sensing precision for Low Earth Orbit (LEO) constellations, yet face fundamental bounds from hardware impairments, pointing errors, and network interference. We develop a Network Cram\'er-Rao Lower Bound (N-CRLB) framework incorporating dynamic topology, hardware quality factor $\Gamma_{\text{eff}}$, phase noise $\sigma^2_\phi$, and cooperative effects through recursive Fisher Information analysis. Our analysis reveals three key insights: (i) hardware and phase noise create power-independent performance ceilings ($\sigma_{\text{ceiling}} \propto \sqrt{\Gamma_{\text{eff}}}$) and floors ($\sigma_{\text{floor}} \propto \sqrt{\sigma^2_\phi}/f_c$), with power-only scaling saturating above $\text{SNR}_{\text{crit}}=1/\Gamma_{\text{eff}}$; (ii) interference coefficients $\alpha_{\ell m}$ enable opportunistic sensing with demonstrated gains of 5.5~dB under specific conditions (65~dB processing gain, 50~dBi antennas); (iii) measurement correlations from shared timing references, when properly modeled, do not degrade performance and can provide common-mode rejection benefits compared to mismodeled independent-noise baselines. Sub-millimeter ranging requires co-optimized hardware ($\Gamma_{\text{eff}}<0.01$), oscillators ($\sigma^2_\phi<10^{-2}$), and appropriate 3D geometry configurations.

HRTFformer: A Spatially-Aware Transformer for Personalized HRTF Upsampling in Immersive Audio Rendering

Personalized Head-Related Transfer Functions (HRTFs) are starting to be introduced in many commercial immersive audio applications and are crucial for realistic spatial audio rendering. However, one of the main hesitations regarding their introduction is that creating personalized HRTFs is impractical at scale due to the complexities of the HRTF measurement process. To mitigate this drawback, HRTF spatial upsampling has been proposed with the aim of reducing measurements required. While prior work has seen success with different machine learning (ML) approaches, these models often struggle with long-range spatial consistency and generalization at high upsampling factors. In this paper, we propose a novel transformer-based architecture for HRTF upsampling, leveraging the attention mechanism to better capture spatial correlations across the HRTF sphere. Working in the spherical harmonic (SH) domain, our model learns to reconstruct high-resolution HRTFs from sparse input measurements with significantly improved accuracy. To enhance spatial coherence, we introduce a neighbor dissimilarity loss that promotes magnitude smoothness, yielding more realistic upsampling. We evaluate our method using both perceptual localization models and objective spectral distortion metrics. Experiments show that our model surpasses leading methods by a substantial margin in generating realistic, high-fidelity HRTFs.

Fundamental Limits of THz Inter-Satellite ISAC Under Hardware Impairments

This paper establishes a theoretical framework for analyzing the fundamental performance limits of terahertz (THz) Low Earth Orbit (LEO) inter-satellite link (ISL) Integrated Sensing and Communications (ISAC) systems. We develop a unified, end-to-end signal model that, jointly captures the effects of extreme orbital dynamics, cascaded non-ideal hardware impairments, and micro-radian beam pointing errors. Through Bayesian Cram\'er-Rao Lower Bound (BCRLB) analysis, we derive the ultimate sensing accuracy for range and range-rate, revealing a quadratic ($1/f_c^2$) improvement in estimation variance with carrier frequency, which is ultimately floored by signal-dependent hardware distortion. For communication, we show that system performance is not power-limited but hardware-limited, deriving a closed-form capacity ceiling under the joint effect of phase noise and PA nonlinearity: $C_{\text{sat}} = \log_2(1 + e^{-\sigma_\phi^2}/\Gamma_{\text{eff}})$, where $\Gamma_{\text{eff}}$ is a proposed hardware quality factor. Our numerical results, based on state-of-the-art component data and the identified trade-offs, suggest that favorable operational conditions may exist in the sub-THz frequency range (200-600 GHz) where the quadratic sensing gain with frequency is balanced against hardware quality degradation. Power Amplifier (PA) nonlinearity emerges as the dominant performance bottleneck, exceeding other impairments by one to two orders of magnitude.

Information and Communication Theoretical Foundations of the Internet of Plants, Principles, Challenges, and Future Directions

Plants exchange information through multiple modalities, including chemical, electrical, mycorrhizal, and acoustic signaling, which collectively support survival, defense, and adaptation. While these processes are well documented in biology, their systematic analysis from an Information and Communication Technology (ICT) perspective remains limited. To address this gap, this article is presented as a tutorial with survey elements. It provides the necessary biological background, reformulates inter-plant signaling within ICT frameworks, and surveys empirical studies to guide future research and applications. First, the paper introduces the fundamental biological processes to establish a foundation for readers in communications and networking. Building on this foundation, existing models of emission, propagation, and reception are synthesized for each modality and reformulated in terms of transmitter, channel, and receiver blocks. To complement theory, empirical studies and state-of-the-art sensing approaches are critically examined. Looking forward, the paper identifies open challenges and outlines future research directions, with particular emphasis on the emerging vision of the Internet of Plants (IoP). This paradigm frames plants as interconnected nodes within ecological and technological networks, offering new opportunities for applications in precision agriculture, ecosystem monitoring, climate resilience, and bio-inspired communication systems. By integrating biological insights with ICT frameworks and projecting toward the IoP, this article provides a comprehensive tutorial on plant communication for the communications research community and establishes a foundation for interdisciplinary advances.

Flexure-FET-Based Receiver with Competitive Binding for Interference Mitigation in Molecular Communication

Molecular communication (MC), a biologically inspired technology, enables applications in nanonetworks and the Internet of Everything (IoE), with great potential for intra-body systems such as drug delivery, health monitoring, and disease detection. This paper extends our prior work on the Flexure-FET MC receiver by integrating a competitive binding model to enhance performance in high-interference environments, where multiple molecular species coexist in the reception space. Previous studies have largely focused on ligand concentration estimation and detection, without fully addressing the effects of inter-species competition for receptor binding. Our proposed framework captures this competition, offering a more biologically accurate model for multitarget environments. By incorporating competition dynamics, the model improves understanding of MC behavior under interference. This approach enables fine-tuning of receptor responses by adjusting ligand concentrations and receptor affinities, thereby optimizing the performance of the Flexure-FET MC receiver. Comprehensive analysis shows that accounting for competitive binding is crucial for improving reliability and accuracy in complex MC systems. Factors such as signal-to-noise ratio (SNR), symbol error probability (SEP), interferer concentration, and receptor dynamics are shown to significantly affect performance. The proposed framework highlights the need to manage these factors effectively. Results demonstrate that modeling interference through competitive binding offers a realistic system perspective and allows tuning of receiver response, enabling robust detection in environments with multiple coexisting species.