Semantic Learning for Molecular Communication in Internet of Bio-Nano Things

Molecular communication (MC) provides a foundational framework for information transmission in the Internet of Bio-Nano Things (IoBNT), where efficiency and reliability are crucial. However, the inherent limitations of molecular channels, such as low transmission rates, noise, and inter-symbol interference (ISI), limit their ability to support complex data transmission. This paper proposes an end-to-end semantic learning framework designed to optimize task-oriented molecular communication, with a focus on biomedical diagnostic tasks under resource-constrained conditions. The proposed framework employs a deep encoder-decoder architecture to efficiently extract, quantize, and decode semantic features, prioritizing task-relevant semantic information to enhance diagnostic classification performance. Additionally, a probabilistic channel network is introduced to approximate molecular propagation dynamics, enabling gradient-based optimization for end-to-end learning. Experimental results demonstrate that the proposed semantic framework improves diagnostic accuracy by at least 25% compared to conventional JPEG compression with LDPC coding methods under resource-constrained communication scenarios.