Interpretable Bilingual Multimodal Large Language Model for Diverse Biomedical Tasks

Several medical Multimodal Large Languange Models (MLLMs) have been developed to address tasks involving visual images with textual instructions across various medical modalities, achieving impressive results. Most current medical generalist models are region-agnostic, treating the entire image as a holistic representation. However, they struggle to identify which specific regions they are focusing on when generating a sentence.To mimic the behavior of doctors, who typically begin by reviewing the entire image before concentrating on specific regions for a thorough evaluation, we aim to enhance the capability of medical MLLMs in understanding anatomical regions within entire medical scans. To achieve it, we first formulate Region-Centric tasks and construct a large-scale dataset, MedRegInstruct, to incorporate regional information into training. Combining our collected dataset with other medical multimodal corpora for training, we propose a Region-Aware medical MLLM, MedRegA, which is the first bilingual generalist medical AI system to simultaneously handle image-level and region-level medical vision-language tasks across a broad range of modalities. Our MedRegA not only enables three region-centric tasks, but also achieves the best performance for visual question answering, report generation and medical image classification over 8 modalities, showcasing significant versatility. Experiments demonstrate that our model can not only accomplish powerful performance across various medical vision-language tasks in bilingual settings, but also recognize and detect structures in multimodal medical scans, boosting the interpretability and user interactivity of medical MLLMs. Our project page is https://medrega.github.io.

FITA: Fine-grained Image-Text Aligner for Radiology Report Generation

Radiology report generation aims to automatically generate detailed and coherent descriptive reports alongside radiology images. Previous work mainly focused on refining fine-grained image features or leveraging external knowledge. However, the precise alignment of fine-grained image features with corresponding text descriptions has not been considered. This paper presents a novel method called Fine-grained Image-Text Aligner (FITA) to construct fine-grained alignment for image and text features. It has three novel designs: Image Feature Refiner (IFR), Text Feature Refiner (TFR) and Contrastive Aligner (CA). IFR and TFR aim to learn fine-grained image and text features, respectively. We achieve this by leveraging saliency maps to effectively fuse symptoms with corresponding abnormal visual regions, and by utilizing a meticulously constructed triplet set for training. Finally, CA module aligns fine-grained image and text features using contrastive loss for precise alignment. Results show that our method surpasses existing methods on the widely used benchmark