Impact of Leakage on Data Harmonization in Machine Learning Pipelines in Class Imbalance Across Sites

Machine learning (ML) models benefit from large datasets. Collecting data in biomedical domains is costly and challenging, hence, combining datasets has become a common practice. However, datasets obtained under different conditions could present undesired site-specific variability. Data harmonization methods aim to remove site-specific variance while retaining biologically relevant information. This study evaluates the effectiveness of popularly used ComBat-based methods for harmonizing data in scenarios where the class balance is not equal across sites. We find that these methods struggle with data leakage issues. To overcome this problem, we propose a novel approach PrettYharmonize, designed to harmonize data by pretending the target labels. We validate our approach using controlled datasets designed to benchmark the utility of harmonization. Finally, using real-world MRI and clinical data, we compare leakage-prone methods with PrettYharmonize and show that it achieves comparable performance while avoiding data leakage, particularly in site-target-dependence scenarios.

Methods for segmenting cracks in 3d images of concrete: A comparison based on semi-synthetic images

Concrete is the standard construction material for buildings, bridges, and roads. As safety plays a central role in the design, monitoring, and maintenance of such constructions, it is important to understand the cracking behavior of concrete. Computed tomography captures the microstructure of building materials and allows to study crack initiation and propagation. Manual segmentation of crack surfaces in large 3d images is not feasible. In this paper, automatic crack segmentation methods for 3d images are reviewed and compared. Classical image processing methods (edge detection filters, template matching, minimal path and region growing algorithms) and learning methods (convolutional neural networks, random forests) are considered and tested on semi-synthetic 3d images. Their performance strongly depends on parameter selection which should be adapted to the grayvalue distribution of the images and the geometric properties of the concrete. In general, the learning methods perform best, in particular for thin cracks and low grayvalue contrast.