Integrating Non-Linear Radon Transformation for Diabetic Retinopathy Grading

Diabetic retinopathy is a serious ocular complication that poses a significant threat to patients' vision and overall health. Early detection and accurate grading are essential to prevent vision loss. Current automatic grading methods rely heavily on deep learning applied to retinal fundus images, but the complex, irregular patterns of lesions in these images, which vary in shape and distribution, make it difficult to capture subtle changes. This study introduces RadFuse, a multi-representation deep learning framework that integrates non-linear RadEx-transformed sinogram images with traditional fundus images to enhance diabetic retinopathy detection and grading. Our RadEx transformation, an optimized non-linear extension of the Radon transform, generates sinogram representations to capture complex retinal lesion patterns. By leveraging both spatial and transformed domain information, RadFuse enriches the feature set available to deep learning models, improving the differentiation of severity levels. We conducted extensive experiments on two benchmark datasets, APTOS-2019 and DDR, using three convolutional neural networks (CNNs): ResNeXt-50, MobileNetV2, and VGG19. RadFuse showed significant improvements over fundus-image-only models across all three CNN architectures and outperformed state-of-the-art methods on both datasets. For severity grading across five stages, RadFuse achieved a quadratic weighted kappa of 93.24%, an accuracy of 87.07%, and an F1-score of 87.17%. In binary classification between healthy and diabetic retinopathy cases, the method reached an accuracy of 99.09%, precision of 98.58%, and recall of 99.6%, surpassing previously established models. These results demonstrate RadFuse's capacity to capture complex non-linear features, advancing diabetic retinopathy classification and promoting the integration of advanced mathematical transforms in medical image analysis.

Improving Early Prediction of Type 2 Diabetes Mellitus with ECG-DiaNet: A Multimodal Neural Network Leveraging Electrocardiogram and Clinical Risk Factors

Type 2 Diabetes Mellitus (T2DM) remains a global health challenge, underscoring the need for early and accurate risk prediction. This study presents ECG-DiaNet, a multimodal deep learning model that integrates electrocardiogram (ECG) features with clinical risk factors (CRFs) to enhance T2DM onset prediction. Using data from Qatar Biobank (QBB), we trained and validated models on a development cohort (n=2043) and evaluated performance on a longitudinal test set (n=395) with five-year follow-up. ECG-DiaNet outperformed unimodal ECG-only and CRF-only models, achieving a higher AUROC (0.845 vs 0.8217) than the CRF-only model, with statistical significance (DeLong p<0.001). Reclassification metrics further confirmed improvements: Net Reclassification Improvement (NRI=0.0153) and Integrated Discrimination Improvement (IDI=0.0482). Risk stratification into low-, medium-, and high-risk groups showed ECG-DiaNet achieved superior positive predictive value (PPV) in high-risk individuals. The model's reliance on non-invasive and widely available ECG signals supports its feasibility in clinical and community health settings. By combining cardiac electrophysiology and systemic risk profiles, ECG-DiaNet addresses the multifactorial nature of T2DM and supports precision prevention. These findings highlight the value of multimodal AI in advancing early detection and prevention strategies for T2DM, particularly in underrepresented Middle Eastern populations.

Cross Modality Medical Image Synthesis for Improving Liver Segmentation

Deep learning-based computer-aided diagnosis (CAD) of medical images requires large datasets. However, the lack of large publicly available labeled datasets limits the development of deep learning-based CAD systems. Generative Adversarial Networks (GANs), in particular, CycleGAN, can be used to generate new cross-domain images without paired training data. However, most CycleGAN-based synthesis methods lack the potential to overcome alignment and asymmetry between the input and generated data. We propose a two-stage technique for the synthesis of abdominal MRI using cross-modality translation of abdominal CT. We show that the synthetic data can help improve the performance of the liver segmentation network. We increase the number of abdominal MRI images through cross-modality image transformation of unpaired CT images using a CycleGAN inspired deformation invariant network called EssNet. Subsequently, we combine the synthetic MRI images with the original MRI images and use them to improve the accuracy of the U-Net on a liver segmentation task. We train the U-Net on real MRI images and then on real and synthetic MRI images. Consequently, by comparing both scenarios, we achieve an improvement in the performance of U-Net. In summary, the improvement achieved in the Intersection over Union (IoU) is 1.17%. The results show potential to address the data scarcity challenge in medical imaging.

Deep Learning for Surgical Instrument Recognition and Segmentation in Robotic-Assisted Surgeries: A Systematic Review

Applying deep learning (DL) for annotating surgical instruments in robot-assisted minimally invasive surgeries (MIS) represents a significant advancement in surgical technology. This systematic review examines 48 studies that and advanced DL methods and architectures. These sophisticated DL models have shown notable improvements in the precision and efficiency of detecting and segmenting surgical tools. The enhanced capabilities of these models support various clinical applications, including real-time intraoperative guidance, comprehensive postoperative evaluations, and objective assessments of surgical skills. By accurately identifying and segmenting surgical instruments in video data, DL models provide detailed feedback to surgeons, thereby improving surgical outcomes and reducing complication risks. Furthermore, the application of DL in surgical education is transformative. The review underscores the significant impact of DL on improving the accuracy of skill assessments and the overall quality of surgical training programs. However, implementing DL in surgical tool detection and segmentation faces challenges, such as the need for large, accurately annotated datasets to train these models effectively. The manual annotation process is labor-intensive and time-consuming, posing a significant bottleneck. Future research should focus on automating the detection and segmentation process and enhancing the robustness of DL models against environmental variations. Expanding the application of DL models across various surgical specialties will be essential to fully realize this technology's potential. Integrating DL with other emerging technologies, such as augmented reality (AR), also offers promising opportunities to further enhance the precision and efficacy of surgical procedures.

MemeMind at ArAIEval Shared Task: Spotting Persuasive Spans in Arabic Text with Persuasion Techniques Identification

This paper focuses on detecting propagandistic spans and persuasion techniques in Arabic text from tweets and news paragraphs. Each entry in the dataset contains a text sample and corresponding labels that indicate the start and end positions of propaganda techniques within the text. Tokens falling within a labeled span were assigned "B" (Begin) or "I" (Inside), "O", corresponding to the specific propaganda technique. Using attention masks, we created uniform lengths for each span and assigned BIO tags to each token based on the provided labels. Then, we used AraBERT-base pre-trained model for Arabic text tokenization and embeddings with a token classification layer to identify propaganda techniques. Our training process involves a two-phase fine-tuning approach. First, we train only the classification layer for a few epochs, followed by full model fine-tuning, updating all parameters. This methodology allows the model to adapt to the specific characteristics of the propaganda detection task while leveraging the knowledge captured by the pre-trained AraBERT model. Our approach achieved an F1 score of 0.2774, securing the 3rd position in the leaderboard of Task 1.

An Early Investigation into the Utility of Multimodal Large Language Models in Medical Imaging

Recent developments in multimodal large language models (MLLMs) have spurred significant interest in their potential applications across various medical imaging domains. On the one hand, there is a temptation to use these generative models to synthesize realistic-looking medical image data, while on the other hand, the ability to identify synthetic image data in a pool of data is also significantly important. In this study, we explore the potential of the Gemini (\textit{gemini-1.0-pro-vision-latest}) and GPT-4V (gpt-4-vision-preview) models for medical image analysis using two modalities of medical image data. Utilizing synthetic and real imaging data, both Gemini AI and GPT-4V are first used to classify real versus synthetic images, followed by an interpretation and analysis of the input images. Experimental results demonstrate that both Gemini and GPT-4 could perform some interpretation of the input images. In this specific experiment, Gemini was able to perform slightly better than the GPT-4V on the classification task. In contrast, responses associated with GPT-4V were mostly generic in nature. Our early investigation presented in this work provides insights into the potential of MLLMs to assist with the classification and interpretation of retinal fundoscopy and lung X-ray images. We also identify key limitations associated with the early investigation study on MLLMs for specialized tasks in medical image analysis.

Pushing Boundaries: Exploring Zero Shot Object Classification with Large Multimodal Models

$ $The synergy of language and vision models has given rise to Large Language and Vision Assistant models (LLVAs), designed to engage users in rich conversational experiences intertwined with image-based queries. These comprehensive multimodal models seamlessly integrate vision encoders with Large Language Models (LLMs), expanding their applications in general-purpose language and visual comprehension. The advent of Large Multimodal Models (LMMs) heralds a new era in Artificial Intelligence (AI) assistance, extending the horizons of AI utilization. This paper takes a unique perspective on LMMs, exploring their efficacy in performing image classification tasks using tailored prompts designed for specific datasets. We also investigate the LLVAs zero-shot learning capabilities. Our study includes a benchmarking analysis across four diverse datasets: MNIST, Cats Vs. Dogs, Hymnoptera (Ants Vs. Bees), and an unconventional dataset comprising Pox Vs. Non-Pox skin images. The results of our experiments demonstrate the model's remarkable performance, achieving classification accuracies of 85\%, 100\%, 77\%, and 79\% for the respective datasets without any fine-tuning. To bolster our analysis, we assess the model's performance post fine-tuning for specific tasks. In one instance, fine-tuning is conducted over a dataset comprising images of faces of children with and without autism. Prior to fine-tuning, the model demonstrated a test accuracy of 55\%, which significantly improved to 83\% post fine-tuning. These results, coupled with our prior findings, underscore the transformative potential of LLVAs and their versatile applications in real-world scenarios.

Can ChatGPT be Your Personal Medical Assistant?

The advanced large language model (LLM) ChatGPT has shown its potential in different domains and remains unbeaten due to its characteristics compared to other LLMs. This study aims to evaluate the potential of using a fine-tuned ChatGPT model as a personal medical assistant in the Arabic language. To do so, this study uses publicly available online questions and answering datasets in Arabic language. There are almost 430K questions and answers for 20 disease-specific categories. GPT-3.5-turbo model was fine-tuned with a portion of this dataset. The performance of this fine-tuned model was evaluated through automated and human evaluation. The automated evaluations include perplexity, coherence, similarity, and token count. Native Arabic speakers with medical knowledge evaluated the generated text by calculating relevance, accuracy, precision, logic, and originality. The overall result shows that ChatGPT has a bright future in medical assistance.

Improving diagnosis and prognosis of lung cancer using vision transformers: A scoping review

Vision transformer-based methods are advancing the field of medical artificial intelligence and cancer imaging, including lung cancer applications. Recently, many researchers have developed vision transformer-based AI methods for lung cancer diagnosis and prognosis. This scoping review aims to identify the recent developments on vision transformer-based AI methods for lung cancer imaging applications. It provides key insights into how vision transformers complemented the performance of AI and deep learning methods for lung cancer. Furthermore, the review also identifies the datasets that contributed to advancing the field. Of the 314 retrieved studies, this review included 34 studies published from 2020 to 2022. The most commonly addressed task in these studies was the classification of lung cancer types, such as lung squamous cell carcinoma versus lung adenocarcinoma, and identifying benign versus malignant pulmonary nodules. Other applications included survival prediction of lung cancer patients and segmentation of lungs. The studies lacked clear strategies for clinical transformation. SWIN transformer was a popular choice of the researchers; however, many other architectures were also reported where vision transformer was combined with convolutional neural networks or UNet model. It can be concluded that vision transformer-based models are increasingly in popularity for developing AI methods for lung cancer applications. However, their computational complexity and clinical relevance are important factors to be considered for future research work. This review provides valuable insights for researchers in the field of AI and healthcare to advance the state-of-the-art in lung cancer diagnosis and prognosis. We provide an interactive dashboard on lung-cancer.onrender.com/.

Artificial Intelligence-Based Methods for Precision Medicine: Diabetes Risk Prediction

The rising prevalence of type 2 diabetes mellitus (T2DM) necessitates the development of predictive models for T2DM risk assessment. Artificial intelligence (AI) models are being extensively used for this purpose, but a comprehensive review of their advancements and challenges is lacking. This scoping review analyzes existing literature on AI-based models for T2DM risk prediction. Forty studies were included, mainly published in the past four years. Traditional machine learning models were more prevalent than deep learning models. Electronic health records were the most commonly used data source. Unimodal AI models relying on EHR data were prominent, while only a few utilized multimodal models. Both unimodal and multimodal models showed promising performance, with the latter outperforming the former. Internal validation was common, while external validation was limited. Interpretability methods were reported in half of the studies. Few studies reported novel biomarkers, and open-source code availability was limited. This review provides insights into the current state and limitations of AI-based T2DM risk prediction models and highlights challenges for their development and clinical implementation.