Assessment of Developmental Dysgraphia Utilising a Display Tablet

Even though the computerised assessment of developmental dysgraphia (DD) based on online handwriting processing has increasing popularity, most of the solutions are based on a setup, where a child writes on a paper fixed to a digitizing tablet that is connected to a computer. Although this approach enables the standard way of writing using an inking pen, it is difficult to be administered by children themselves. The main goal of this study is thus to explore, whether the quantitative analysis of online handwriting recorded via a display screen tablet could sufficiently support the assessment of DD as well. For the purpose of this study, we enrolled 144 children (attending the 3rd and 4th class of a primary school), whose handwriting proficiency was assessed by a special education counsellor, and who assessed themselves by the Handwriting Proficiency Screening Questionnaires for Children (HPSQ C). Using machine learning models based on a gradient-boosting algorithm, we were able to support the DD diagnosis with up to 83.6% accuracy. The HPSQ C total score was estimated with a minimum error equal to 10.34 %. Children with DD spent significantly higher time in-air, they had a higher number of pen elevations, a bigger height of on-surface strokes, a lower in-air tempo, and a higher variation in the angular velocity. Although this study shows a promising impact of DD assessment via display tablets, it also accents the fact that modelling of subjective scores is challenging and a complex and data-driven quantification of DD manifestations is needed.

Graphomotor and Handwriting Disabilities Rating Scale (GHDRS):towards complex and objective assessment

Graphomotor and handwriting disabilities (GD and HD, respectively) could significantly reduce children's quality of life. Effective remediation depends on proper diagnosis; however, current approaches to diagnosis and assessment of GD and HD have several limitations and knowledge gaps, e.g. they are subjective, they do not facilitate identification of specific manifestations, etc. The aim of this work is to introduce a new scale (GHDRS Graphomotor and Handwriting Disabilities Rating Scale) that will enable experts to perform objective and complex computeraided diagnosis and assessment of GD and HD. The scale supports quantification of 17 manifestations associated with the process/product of drawing/ handwriting. The whole methodology of GHDRS design is made maximally transparent so that it could be adapted for other languages.

Deep Learning for In-Orbit Cloud Segmentation and Classification in Hyperspectral Satellite Data

This article explores the latest Convolutional Neural Networks (CNNs) for cloud detection aboard hyperspectral satellites. The performance of the latest 1D CNN (1D-Justo-LiuNet) and two recent 2D CNNs (nnU-net and 2D-Justo-UNet-Simple) for cloud segmentation and classification is assessed. Evaluation criteria include precision and computational efficiency for in-orbit deployment. Experiments utilize NASA's EO-1 Hyperion data, with varying spectral channel numbers after Principal Component Analysis. Results indicate that 1D-Justo-LiuNet achieves the highest accuracy, outperforming 2D CNNs, while maintaining compactness with larger spectral channel sets, albeit with increased inference times. However, the performance of 1D CNN degrades with significant channel reduction. In this context, the 2D-Justo-UNet-Simple offers the best balance for in-orbit deployment, considering precision, memory, and time costs. While nnU-net is suitable for on-ground processing, deployment of lightweight 1D-Justo-LiuNet is recommended for high-precision applications. Alternatively, lightweight 2D-Justo-UNet-Simple is recommended for balanced costs between timing and precision in orbit.

Exploration of Various Fractional Order Derivatives in Parkinson's Disease Dysgraphia Analysis

Parkinson's disease (PD) is a common neurodegenerative disorder with a prevalence rate estimated to 2.0% for people aged over 65 years. Cardinal motor symptoms of PD such as rigidity and bradykinesia affect the muscles involved in the handwriting process resulting in handwriting abnormalities called PD dysgraphia. Nowadays, online handwritten signal (signal with temporal information) acquired by the digitizing tablets is the most advanced approach of graphomotor difficulties analysis. Although the basic kinematic features were proved to effectively quantify the symptoms of PD dysgraphia, a recent research identified that the theory of fractional calculus can be used to improve the graphomotor difficulties analysis. Therefore, in this study, we follow up on our previous research, and we aim to explore the utilization of various approaches of fractional order derivative (FD) in the analysis of PD dysgraphia. For this purpose, we used the repetitive loops task from the Parkinson's disease handwriting database (PaHaW). Handwritten signals were parametrized by the kinematic features employing three FD approximations: Gr\"unwald-Letnikov's, Riemann-Liouville's, and Caputo's. Results of the correlation analysis revealed a significant relationship between the clinical state and the handwriting features based on the velocity. The extracted features by Caputo's FD approximation outperformed the rest of the analyzed FD approaches. This was also confirmed by the results of the classification analysis, where the best model trained by Caputo's handwriting features resulted in a balanced accuracy of 79.73% with a sensitivity of 83.78% and a specificity of 75.68%.

Prodromal Diagnosis of Lewy Body Diseases Based on the Assessment of Graphomotor and Handwriting Difficulties

To this date, studies focusing on the prodromal diagnosis of Lewy body diseases (LBDs) based on quantitative analysis of graphomotor and handwriting difficulties are missing. In this work, we enrolled 18 subjects diagnosed with possible or probable mild cognitive impairment with Lewy bodies (MCI-LB), 7 subjects having more than 50% probability of developing Parkinson's disease (PD), 21 subjects with both possible/probable MCI-LB and probability of PD > 50%, and 37 age- and gender-matched healthy controls (HC). Each participant performed three tasks: Archimedean spiral drawing (to quantify graphomotor difficulties), sentence writing task (to quantify handwriting difficulties), and pentagon copying test (to quantify cognitive decline). Next, we parameterized the acquired data by various temporal, kinematic, dynamic, spatial, and task-specific features. And finally, we trained classification models for each task separately as well as a model for their combination to estimate the predictive power of the features for the identification of LBDs. Using this approach we were able to identify prodromal LBDs with 74% accuracy and showed the promising potential of computerized objective and non-invasive diagnosis of LBDs based on the assessment of graphomotor and handwriting difficulties.

Perceptual Features as Markers of Parkinson's Disease: The Issue of Clinical Interpretability

Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) which is also manifested in the field of phonation. Clinical signs of HD like monoloudness, monopitch or hoarse voice are usually quantified by conventional clinical interpretable features (jitter, shimmer, harmonic-to-noise ratio, etc.). This paper provides large and robust insight into perceptual analysis of 5 Czech vowels of 84 PD patients and proves that despite the clinical inexplicability the perceptual features outperform the conventional ones, especially in terms of discrimination power (classification accuracy ACC = 92 %, sensitivity SEN = 93 %, specificity SPE = 92 %) and partial correlation with clinical scores like UPDRS (Unified Parkinson's disease rating scale), MMSE (Mini-mental state examination) or FOG (Freezing of gait questionnaire), where p < 0.0001.

Identification of Hypokinetic Dysarthria Using Acoustic Analysis of Poem Recitation

Up to 90 % of patients with Parkinson's disease (PD) suffer from hypokinetic dysarthria (HD). In this work, we analysed the power of conventional speech features quantifying imprecise articulation, dysprosody, speech dysfluency and speech quality deterioration extracted from a specialized poem recitation task to discriminate dysarthric and healthy speech. For this purpose, 152 speakers (53 healthy speakers, 99 PD patients) were examined. Only mildly strong correlation between speech features and clinical status of the speakers was observed. In the case of univariate classification analysis, sensitivity of 62.63% (imprecise articulation), 61.62% (dysprosody), 71.72% (speech dysfluency) and 59.60% (speech quality deterioration) was achieved. Multivariate classification analysis improved the classification performance. Sensitivity of 83.42% using only two features describing imprecise articulation and speech quality deterioration in HD was achieved. We showed the promising potential of the selected speech features and especially the use of poem recitation task to quantify and identify HD in PD.

Assessing Progress of Parkinson s Disease Using Acoustic Analysis of Phonation

This paper deals with a complex acoustic analysis of phonation in patients with Parkinson's disease (PD) with a special focus on estimation of disease progress that is described by 7 different clinical scales ,e. g. Unified Parkinson's disease rating scale or Beck depression inventory. The analysis is based on parametrization of 5 Czech vowels pronounced by 84 PD patients. Using classification and regression trees we estimated all clinical scores with maximal error lower or equal to 13 %. Best estimation was observed in the case of Mini-mental state examination (MAE = 0.77, estimation error 5.50 %. Finally, we proposed a binary classification based on random forests that is able to identify Parkinson's disease with sensitivity SEN = 92.86 % (SPE = 85.71 %). The parametrization process was based on extraction of 107 speech features quantifying different clinical signs of hypokinetic dysarthria present in PD.

Towards Robust Voice Pathology Detection

Automatic objective non-invasive detection of pathological voice based on computerized analysis of acoustic signals can play an important role in early diagnosis, progression tracking and even effective treatment of pathological voices. In search towards such a robust voice pathology detection system we investigated 3 distinct classifiers within supervised learning and anomaly detection paradigms. We conducted a set of experiments using a variety of input data such as raw waveforms, spectrograms, mel-frequency cepstral coefficients (MFCC) and conventional acoustic (dysphonic) features (AF). In comparison with previously published works, this article is the first to utilize combination of 4 different databases comprising normophonic and pathological recordings of sustained phonation of the vowel /a/ unrestricted to a subset of vocal pathologies. Furthermore, to our best knowledge, this article is the first to explore gradient boosted trees and deep learning for this application. The following best classification performances measured by F1 score on dedicated test set were achieved: XGBoost (0.733) using AF and MFCC, DenseNet (0.621) using MFCC, and Isolation Forest (0.610) using AF. Even though these results are of exploratory character, conducted experiments do show promising potential of gradient boosting and deep learning methods to robustly detect voice pathologies.

Voice Pathology Detection Using Deep Learning: a Preliminary Study

This paper describes a preliminary investigation of Voice Pathology Detection using Deep Neural Networks (DNN). We used voice recordings of sustained vowel /a/ produced at normal pitch from German corpus Saarbruecken Voice Database (SVD). This corpus contains voice recordings and electroglottograph signals of more than 2 000 speakers. The idea behind this experiment is the use of convolutional layers in combination with recurrent Long-Short-Term-Memory (LSTM) layers on raw audio signal. Each recording was split into 64 ms Hamming windowed segments with 30 ms overlap. Our trained model achieved 71.36% accuracy with 65.04% sensitivity and 77.67% specificity on 206 validation files and 68.08% accuracy with 66.75% sensitivity and 77.89% specificity on 874 testing files. This is a promising result in favor of this approach because it is comparable to similar previously published experiment that used different methodology. Further investigation is needed to achieve the state-of-the-art results.