BLS-GAN: A Deep Layer Separation Framework for Eliminating Bone Overlap in Conventional Radiographs

Conventional radiography is the widely used imaging technology in diagnosing, monitoring, and prognosticating musculoskeletal (MSK) diseases because of its easy availability, versatility, and cost-effectiveness. In conventional radiographs, bone overlaps are prevalent, and can impede the accurate assessment of bone characteristics by radiologists or algorithms, posing significant challenges to conventional and computer-aided diagnoses. This work initiated the study of a challenging scenario - bone layer separation in conventional radiographs, in which separate overlapped bone regions enable the independent assessment of the bone characteristics of each bone layer and lay the groundwork for MSK disease diagnosis and its automation. This work proposed a Bone Layer Separation GAN (BLS-GAN) framework that can produce high-quality bone layer images with reasonable bone characteristics and texture. This framework introduced a reconstructor based on conventional radiography imaging principles, which achieved efficient reconstruction and mitigates the recurrent calculations and training instability issues caused by soft tissue in the overlapped regions. Additionally, pre-training with synthetic images was implemented to enhance the stability of both the training process and the results. The generated images passed the visual Turing test, and improved performance in downstream tasks. This work affirms the feasibility of extracting bone layer images from conventional radiographs, which holds promise for leveraging bone layer separation technology to facilitate more comprehensive analytical research in MSK diagnosis, monitoring, and prognosis. Code and dataset will be made available.

From Decision to Action in Surgical Autonomy: Multi-Modal Large Language Models for Robot-Assisted Blood Suction

The rise of Large Language Models (LLMs) has impacted research in robotics and automation. While progress has been made in integrating LLMs into general robotics tasks, a noticeable void persists in their adoption in more specific domains such as surgery, where critical factors such as reasoning, explainability, and safety are paramount. Achieving autonomy in robotic surgery, which entails the ability to reason and adapt to changes in the environment, remains a significant challenge. In this work, we propose a multi-modal LLM integration in robot-assisted surgery for autonomous blood suction. The reasoning and prioritization are delegated to the higher-level task-planning LLM, and the motion planning and execution are handled by the lower-level deep reinforcement learning model, creating a distributed agency between the two components. As surgical operations are highly dynamic and may encounter unforeseen circumstances, blood clots and active bleeding were introduced to influence decision-making. Results showed that using a multi-modal LLM as a higher-level reasoning unit can account for these surgical complexities to achieve a level of reasoning previously unattainable in robot-assisted surgeries. These findings demonstrate the potential of multi-modal LLMs to significantly enhance contextual understanding and decision-making in robotic-assisted surgeries, marking a step toward autonomous surgical systems.

Tri-VQA: Triangular Reasoning Medical Visual Question Answering for Multi-Attribute Analysis

The intersection of medical Visual Question Answering (Med-VQA) is a challenging research topic with advantages including patient engagement and clinical expert involvement for second opinions. However, existing Med-VQA methods based on joint embedding fail to explain whether their provided results are based on correct reasoning or coincidental answers, which undermines the credibility of VQA answers. In this paper, we investigate the construction of a more cohesive and stable Med-VQA structure. Motivated by causal effect, we propose a novel Triangular Reasoning VQA (Tri-VQA) framework, which constructs reverse causal questions from the perspective of "Why this answer?" to elucidate the source of the answer and stimulate more reasonable forward reasoning processes. We evaluate our method on the Endoscopic Ultrasound (EUS) multi-attribute annotated dataset from five centers, and test it on medical VQA datasets. Experimental results demonstrate the superiority of our approach over existing methods. Our codes and pre-trained models are available at https://anonymous.4open.science/r/Tri_VQA.

MDA: An Interpretable Multi-Modal Fusion with Missing Modalities and Intrinsic Noise

Multi-modal fusion is crucial in medical data research, enabling a comprehensive understanding of diseases and improving diagnostic performance by combining diverse modalities. However, multi-modal fusion faces challenges, including capturing interactions between modalities, addressing missing modalities, handling erroneous modal information, and ensuring interpretability. Many existing researchers tend to design different solutions for these problems, often overlooking the commonalities among them. This paper proposes a novel multi-modal fusion framework that achieves adaptive adjustment over the weights of each modality by introducing the Modal-Domain Attention (MDA). It aims to facilitate the fusion of multi-modal information while allowing for the inclusion of missing modalities or intrinsic noise, thereby enhancing the representation of multi-modal data. We provide visualizations of accuracy changes and MDA weights by observing the process of modal fusion, offering a comprehensive analysis of its interpretability. Extensive experiments on various gastrointestinal disease benchmarks, the proposed MDA maintains high accuracy even in the presence of missing modalities and intrinsic noise. One thing worth mentioning is that the visualization of MDA is highly consistent with the conclusions of existing clinical studies on the dependence of different diseases on various modalities. Code and dataset will be made available.

A Realistic Surgical Simulator for Non-Rigid and Contact-Rich Manipulation in Surgeries with the da Vinci Research Kit

Realistic real-time surgical simulators play an increasingly important role in surgical robotics research, such as surgical robot learning and automation, and surgical skills assessment. Although there are a number of existing surgical simulators for research, they generally lack the ability to simulate the diverse types of objects and contact-rich manipulation tasks typically present in surgeries, such as tissue cutting and blood suction. In this work, we introduce CRESSim, a realistic surgical simulator based on PhysX 5 for the da Vinci Research Kit (dVRK) that enables simulating various contact-rich surgical tasks involving different surgical instruments, soft tissue, and body fluids. The real-world dVRK console and the master tool manipulator (MTM) robots are incorporated into the system to allow for teleoperation through virtual reality (VR). To showcase the advantages and potentials of the simulator, we present three examples of surgical tasks, including tissue grasping and deformation, blood suction, and tissue cutting. These tasks are performed using the simulated surgical instruments, including the large needle driver, suction irrigator, and curved scissor, through VR-based teleoperation.

Halo Reduction in Display Systems through Smoothed Local Histogram Equalization and Human Visual System Modeling

Halo artifacts significantly impact display quality. We propose a method to reduce halos in Local Histogram Equalization (LHE) algorithms by separately addressing dark and light variants. This approach results in visually natural images by exploring the relationship between lateral inhibition and halo artifacts in the human visual system.

A Psychological Study: Importance of Contrast and Luminance in Color to Grayscale Mapping

Grayscale images are essential in image processing and computer vision tasks. They effectively emphasize luminance and contrast, highlighting important visual features, while also being easily compatible with other algorithms. Moreover, their simplified representation makes them efficient for storage and transmission purposes. While preserving contrast is important for maintaining visual quality, other factors such as preserving information relevant to the specific application or task at hand may be more critical for achieving optimal performance. To evaluate and compare different decolorization algorithms, we designed a psychological experiment. During the experiment, participants were instructed to imagine color images in a hypothetical "colorless world" and select the grayscale image that best resembled their mental visualization. We conducted a comparison between two types of algorithms: (i) perceptual-based simple color space conversion algorithms, and (ii) spatial contrast-based algorithms, including iteration-based methods. Our experimental findings indicate that CIELAB exhibited superior performance on average, providing further evidence for the effectiveness of perception-based decolorization algorithms. On the other hand, the spatial contrast-based algorithms showed relatively poorer performance, possibly due to factors such as DC-offset and artificial contrast generation. However, these algorithms demonstrated shorter selection times. Notably, no single algorithm consistently outperformed the others across all test images. In this paper, we will delve into a comprehensive discussion on the significance of contrast and luminance in color-to-grayscale mapping based on our experimental results and analysis.

Sparse Anatomical Prompt Semi-Supervised Learning with Masked Image Modeling for CBCT Tooth Segmentation

Accurate tooth identification and segmentation in Cone Beam Computed Tomography (CBCT) dental images can significantly enhance the efficiency and precision of manual diagnoses performed by dentists. However, existing segmentation methods are mainly developed based on large data volumes training, on which their annotations are extremely time-consuming. Meanwhile, the teeth of each class in CBCT dental images being closely positioned, coupled with subtle inter-class differences, gives rise to the challenge of indistinct boundaries when training model with limited data. To address these challenges, this study aims to propose a tasked-oriented Masked Auto-Encoder paradigm to effectively utilize large amounts of unlabeled data to achieve accurate tooth segmentation with limited labeled data. Specifically, we first construct a self-supervised pre-training framework of masked auto encoder to efficiently utilize unlabeled data to enhance the network performance. Subsequently, we introduce a sparse masked prompt mechanism based on graph attention to incorporate boundary information of the teeth, aiding the network in learning the anatomical structural features of teeth. To the best of our knowledge, we are pioneering the integration of the mask pre-training paradigm into the CBCT tooth segmentation task. Extensive experiments demonstrate both the feasibility of our proposed method and the potential of the boundary prompt mechanism.

Sim-to-Real Surgical Robot Learning and Autonomous Planning for Internal Tissue Points Manipulation using Reinforcement Learning

Indirect simultaneous positioning (ISP), where internal tissue points are placed at desired locations indirectly through the manipulation of boundary points, is a type of subtask frequently performed in robotic surgeries. Although challenging due to complex tissue dynamics, automating the task can potentially reduce the workload of surgeons. This paper presents a sim-to-real framework for learning to automate the task without interacting with a real environment, and for planning preoperatively to find the grasping points that minimize local tissue deformation. A control policy is learned using deep reinforcement learning (DRL) in the FEM-based simulation environment and transferred to real-world situation. Grasping points are planned in the simulator by utilizing the trained policy using Bayesian optimization (BO). Inconsistent simulation performance is overcome by formulating the problem as a state augmented Markov decision process (MDP). Experimental results show that the learned policy places the internal tissue points accurately, and that the planned grasping points yield small tissue deformation among the trials. The proposed learning and planning scheme is able to automate internal tissue point manipulation in surgeries and has the potential to be generalized to complex surgical scenarios.

A Deep Registration Method for Accurate Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that results in progressive articular destruction and severe disability. Joint space narrowing (JSN) progression has been regarded as an important indicator for RA progression and has received sustained attention. In the diagnosis and monitoring of RA, radiology plays a crucial role to monitor joint space. A new framework for monitoring joint space by quantifying JSN progression through image registration in radiographic images has been developed. This framework offers the advantage of high accuracy, however, challenges do exist in reducing mismatches and improving reliability. In this work, a deep intra-subject rigid registration network is proposed to automatically quantify JSN progression in the early stage of RA. In our experiments, the mean-square error of Euclidean distance between moving and fixed image is 0.0031, standard deviation is 0.0661 mm, and the mismatching rate is 0.48\%. The proposed method has sub-pixel level accuracy, exceeding manual measurements by far, and is equipped with immune to noise, rotation, and scaling of joints. Moreover, this work provides loss visualization, which can aid radiologists and rheumatologists in assessing quantification reliability, with important implications for possible future clinical applications. As a result, we are optimistic that this proposed work will make a significant contribution to the automatic quantification of JSN progression in RA.