MDA: An Interpretable Multi-Modal Fusion with Missing Modalities and Intrinsic Noise

Multi-modal fusion is crucial in medical data research, enabling a comprehensive understanding of diseases and improving diagnostic performance by combining diverse modalities. However, multi-modal fusion faces challenges, including capturing interactions between modalities, addressing missing modalities, handling erroneous modal information, and ensuring interpretability. Many existing researchers tend to design different solutions for these problems, often overlooking the commonalities among them. This paper proposes a novel multi-modal fusion framework that achieves adaptive adjustment over the weights of each modality by introducing the Modal-Domain Attention (MDA). It aims to facilitate the fusion of multi-modal information while allowing for the inclusion of missing modalities or intrinsic noise, thereby enhancing the representation of multi-modal data. We provide visualizations of accuracy changes and MDA weights by observing the process of modal fusion, offering a comprehensive analysis of its interpretability. Extensive experiments on various gastrointestinal disease benchmarks, the proposed MDA maintains high accuracy even in the presence of missing modalities and intrinsic noise. One thing worth mentioning is that the visualization of MDA is highly consistent with the conclusions of existing clinical studies on the dependence of different diseases on various modalities. Code and dataset will be made available.