Devil in the Tail: A Multi-Modal Framework for Drug-Drug Interaction Prediction in Long Tail Distinction

Drug-drug interaction (DDI) identification is a crucial aspect of pharmacology research. There are many DDI types (hundreds), and they are not evenly distributed with equal chance to occur. Some of the rarely occurred DDI types are often high risk and could be life-critical if overlooked, exemplifying the long-tailed distribution problem. Existing models falter against this distribution challenge and overlook the multi-faceted nature of drugs in DDI prediction. In this paper, a novel multi-modal deep learning-based framework, namely TFDM, is introduced to leverage multiple properties of a drug to achieve DDI classification. The proposed framework fuses multimodal features of drugs, including graph-based, molecular structure, Target and Enzyme, for DDI identification. To tackle the challenge posed by the distribution skewness across categories, a novel loss function called Tailed Focal Loss is introduced, aimed at further enhancing the model performance and address gradient vanishing problem of focal loss in extremely long-tailed dataset. Intensive experiments over 4 challenging long-tailed dataset demonstrate that the TFMD outperforms the most recent SOTA methods in long-tailed DDI classification tasks. The source code is released to reproduce our experiment results: https://github.com/IcurasLW/TFMD_Longtailed_DDI.git

Irregularity-Informed Time Series Analysis: Adaptive Modelling of Spatial and Temporal Dynamics

Irregular Time Series Data (IRTS) has shown increasing prevalence in real-world applications. We observed that IRTS can be divided into two specialized types: Natural Irregular Time Series (NIRTS) and Accidental Irregular Time Series (AIRTS). Various existing methods either ignore the impacts of irregular patterns or statically learn the irregular dynamics of NIRTS and AIRTS data and suffer from limited data availability due to the sparsity of IRTS. We proposed a novel transformer-based framework for general irregular time series data that treats IRTS from four views: Locality, Time, Spatio and Irregularity to motivate the data usage to the highest potential. Moreover, we design a sophisticated irregularity-gate mechanism to adaptively select task-relevant information from irregularity, which improves the generalization ability to various IRTS data. We implement extensive experiments to demonstrate the resistance of our work to three highly missing ratio datasets (88.4\%, 94.9\%, 60\% missing value) and investigate the significance of the irregularity information for both NIRTS and AIRTS by additional ablation study. We release our implementation in https://github.com/IcurasLW/MTSFormer-Irregular_Time_Series.git

Revisited Large Language Model for Time Series Analysis through Modality Alignment

Large Language Models have demonstrated impressive performance in many pivotal web applications such as sensor data analysis. However, since LLMs are not designed for time series tasks, simpler models like linear regressions can often achieve comparable performance with far less complexity. In this study, we perform extensive experiments to assess the effectiveness of applying LLMs to key time series tasks, including forecasting, classification, imputation, and anomaly detection. We compare the performance of LLMs against simpler baseline models, such as single-layer linear models and randomly initialized LLMs. Our results reveal that LLMs offer minimal advantages for these core time series tasks and may even distort the temporal structure of the data. In contrast, simpler models consistently outperform LLMs while requiring far fewer parameters. Furthermore, we analyze existing reprogramming techniques and show, through data manifold analysis, that these methods fail to effectively align time series data with language and display pseudo-alignment behaviour in embedding space. Our findings suggest that the performance of LLM-based methods in time series tasks arises from the intrinsic characteristics and structure of time series data, rather than any meaningful alignment with the language model architecture.

Boosting Certificate Robustness for Time Series Classification with Efficient Self-Ensemble

Recently, the issue of adversarial robustness in the time series domain has garnered significant attention. However, the available defense mechanisms remain limited, with adversarial training being the predominant approach, though it does not provide theoretical guarantees. Randomized Smoothing has emerged as a standout method due to its ability to certify a provable lower bound on robustness radius under $\ell_p$-ball attacks. Recognizing its success, research in the time series domain has started focusing on these aspects. However, existing research predominantly focuses on time series forecasting, or under the non-$\ell_p$ robustness in statistic feature augmentation for time series classification~(TSC). Our review found that Randomized Smoothing performs modestly in TSC, struggling to provide effective assurances on datasets with poor robustness. Therefore, we propose a self-ensemble method to enhance the lower bound of the probability confidence of predicted labels by reducing the variance of classification margins, thereby certifying a larger radius. This approach also addresses the computational overhead issue of Deep Ensemble~(DE) while remaining competitive and, in some cases, outperforming it in terms of robustness. Both theoretical analysis and experimental results validate the effectiveness of our method, demonstrating superior performance in robustness testing compared to baseline approaches.

Rethinking Transformer-based Multi-document Summarization: An Empirical Investigation

The utilization of Transformer-based models prospers the growth of multi-document summarization (MDS). Given the huge impact and widespread adoption of Transformer-based models in various natural language processing tasks, investigating their performance and behaviors in the context of MDS becomes crucial for advancing the field and enhancing the quality of summary. To thoroughly examine the behaviours of Transformer-based MDS models, this paper presents five empirical studies on (1) measuring the impact of document boundary separators quantitatively; (2) exploring the effectiveness of different mainstream Transformer structures; (3) examining the sensitivity of the encoder and decoder; (4) discussing different training strategies; and (5) discovering the repetition in a summary generation. The experimental results on prevalent MDS datasets and eleven evaluation metrics show the influence of document boundary separators, the granularity of different level features and different model training strategies. The results also reveal that the decoder exhibits greater sensitivity to noises compared to the encoder. This underscores the important role played by the decoder, suggesting a potential direction for future research in MDS. Furthermore, the experimental results indicate that the repetition problem in the generated summaries has correlations with the high uncertainty scores.

Distractor Generation for Multiple-Choice Questions: A Survey of Methods, Datasets, and Evaluation

Distractors are important in learning evaluation. This paper surveys distractor generation tasks using English multiple-choice question datasets for textual and multimodal contexts. In particular, this paper presents a thorough literature review of the recent studies on distractor generation tasks, discusses multiple choice components and their characteristics, analyzes the related datasets, and summarizes the evaluation metrics of distractor generation. Our investigation reveals that more than half of datasets are human-generated from educational sources in specific domains such as Science and English, which are largely text-based, with a lack of open domain and multimodal datasets.

When Large Language Models Meet Citation: A Survey

Citations in scholarly work serve the essential purpose of acknowledging and crediting the original sources of knowledge that have been incorporated or referenced. Depending on their surrounding textual context, these citations are used for different motivations and purposes. Large Language Models (LLMs) could be helpful in capturing these fine-grained citation information via the corresponding textual context, thereby enabling a better understanding towards the literature. Furthermore, these citations also establish connections among scientific papers, providing high-quality inter-document relationships and human-constructed knowledge. Such information could be incorporated into LLMs pre-training and improve the text representation in LLMs. Therefore, in this paper, we offer a preliminary review of the mutually beneficial relationship between LLMs and citation analysis. Specifically, we review the application of LLMs for in-text citation analysis tasks, including citation classification, citation-based summarization, and citation recommendation. We then summarize the research pertinent to leveraging citation linkage knowledge to improve text representations of LLMs via citation prediction, network structure information, and inter-document relationship. We finally provide an overview of these contemporary methods and put forth potential promising avenues in combining LLMs and citation analysis for further investigation.

SWAP: Exploiting Second-Ranked Logits for Adversarial Attacks on Time Series

Time series classification (TSC) has emerged as a critical task in various domains, and deep neural models have shown superior performance in TSC tasks. However, these models are vulnerable to adversarial attacks, where subtle perturbations can significantly impact the prediction results. Existing adversarial methods often suffer from over-parameterization or random logit perturbation, hindering their effectiveness. Additionally, increasing the attack success rate (ASR) typically involves generating more noise, making the attack more easily detectable. To address these limitations, we propose SWAP, a novel attacking method for TSC models. SWAP focuses on enhancing the confidence of the second-ranked logits while minimizing the manipulation of other logits. This is achieved by minimizing the Kullback-Leibler divergence between the target logit distribution and the predictive logit distribution. Experimental results demonstrate that SWAP achieves state-of-the-art performance, with an ASR exceeding 50% and an 18% increase compared to existing methods.

Learning to Select the Relevant History Turns in Conversational Question Answering

The increasing demand for the web-based digital assistants has given a rapid rise in the interest of the Information Retrieval (IR) community towards the field of conversational question answering (ConvQA). However, one of the critical aspects of ConvQA is the effective selection of conversational history turns to answer the question at hand. The dependency between relevant history selection and correct answer prediction is an intriguing but under-explored area. The selected relevant context can better guide the system so as to where exactly in the passage to look for an answer. Irrelevant context, on the other hand, brings noise to the system, thereby resulting in a decline in the model's performance. In this paper, we propose a framework, DHS-ConvQA (Dynamic History Selection in Conversational Question Answering), that first generates the context and question entities for all the history turns, which are then pruned on the basis of similarity they share in common with the question at hand. We also propose an attention-based mechanism to re-rank the pruned terms based on their calculated weights of how useful they are in answering the question. In the end, we further aid the model by highlighting the terms in the re-ranked conversational history using a binary classification task and keeping the useful terms (predicted as 1) and ignoring the irrelevant terms (predicted as 0). We demonstrate the efficacy of our proposed framework with extensive experimental results on CANARD and QuAC -- the two popularly utilized datasets in ConvQA. We demonstrate that selecting relevant turns works better than rewriting the original question. We also investigate how adding the irrelevant history turns negatively impacts the model's performance and discuss the research challenges that demand more attention from the IR community.

Keeping the Questions Conversational: Using Structured Representations to Resolve Dependency in Conversational Question Answering

Having an intelligent dialogue agent that can engage in conversational question answering (ConvQA) is now no longer limited to Sci-Fi movies only and has, in fact, turned into a reality. These intelligent agents are required to understand and correctly interpret the sequential turns provided as the context of the given question. However, these sequential questions are sometimes left implicit and thus require the resolution of some natural language phenomena such as anaphora and ellipsis. The task of question rewriting has the potential to address the challenges of resolving dependencies amongst the contextual turns by transforming them into intent-explicit questions. Nonetheless, the solution of rewriting the implicit questions comes with some potential challenges such as resulting in verbose questions and taking conversational aspect out of the scenario by generating self-contained questions. In this paper, we propose a novel framework, CONVSR (CONVQA using Structured Representations) for capturing and generating intermediate representations as conversational cues to enhance the capability of the QA model to better interpret the incomplete questions. We also deliberate how the strengths of this task could be leveraged in a bid to design more engaging and eloquent conversational agents. We test our model on the QuAC and CANARD datasets and illustrate by experimental results that our proposed framework achieves a better F1 score than the standard question rewriting model.