SkinMamba: A Precision Skin Lesion Segmentation Architecture with Cross-Scale Global State Modeling and Frequency Boundary Guidance

Skin lesion segmentation is a crucial method for identifying early skin cancer. In recent years, both convolutional neural network (CNN) and Transformer-based methods have been widely applied. Moreover, combining CNN and Transformer effectively integrates global and local relationships, but remains limited by the quadratic complexity of Transformer. To address this, we propose a hybrid architecture based on Mamba and CNN, called SkinMamba. It maintains linear complexity while offering powerful long-range dependency modeling and local feature extraction capabilities. Specifically, we introduce the Scale Residual State Space Block (SRSSB), which captures global contextual relationships and cross-scale information exchange at a macro level, enabling expert communication in a global state. This effectively addresses challenges in skin lesion segmentation related to varying lesion sizes and inconspicuous target areas. Additionally, to mitigate boundary blurring and information loss during model downsampling, we introduce the Frequency Boundary Guided Module (FBGM), providing sufficient boundary priors to guide precise boundary segmentation, while also using the retained information to assist the decoder in the decoding process. Finally, we conducted comparative and ablation experiments on two public lesion segmentation datasets (ISIC2017 and ISIC2018), and the results demonstrate the strong competitiveness of SkinMamba in skin lesion segmentation tasks. The code is available at https://github.com/zs1314/SkinMamba.

OCTAMamba: A State-Space Model Approach for Precision OCTA Vasculature Segmentation

Optical Coherence Tomography Angiography (OCTA) is a crucial imaging technique for visualizing retinal vasculature and diagnosing eye diseases such as diabetic retinopathy and glaucoma. However, precise segmentation of OCTA vasculature remains challenging due to the multi-scale vessel structures and noise from poor image quality and eye lesions. In this study, we proposed OCTAMamba, a novel U-shaped network based on the Mamba architecture, designed to segment vasculature in OCTA accurately. OCTAMamba integrates a Quad Stream Efficient Mining Embedding Module for local feature extraction, a Multi-Scale Dilated Asymmetric Convolution Module to capture multi-scale vasculature, and a Focused Feature Recalibration Module to filter noise and highlight target areas. Our method achieves efficient global modeling and local feature extraction while maintaining linear complexity, making it suitable for low-computation medical applications. Extensive experiments on the OCTA 3M, OCTA 6M, and ROSSA datasets demonstrated that OCTAMamba outperforms state-of-the-art methods, providing a new reference for efficient OCTA segmentation. Code is available at https://github.com/zs1314/OCTAMamba

Microscopic-Mamba: Revealing the Secrets of Microscopic Images with Just 4M Parameters

In the field of medical microscopic image classification (MIC), CNN-based and Transformer-based models have been extensively studied. However, CNNs struggle with modeling long-range dependencies, limiting their ability to fully utilize semantic information in images. Conversely, Transformers are hampered by the complexity of quadratic computations. To address these challenges, we propose a model based on the Mamba architecture: Microscopic-Mamba. Specifically, we designed the Partially Selected Feed-Forward Network (PSFFN) to replace the last linear layer of the Visual State Space Module (VSSM), enhancing Mamba's local feature extraction capabilities. Additionally, we introduced the Modulation Interaction Feature Aggregation (MIFA) module to effectively modulate and dynamically aggregate global and local features. We also incorporated a parallel VSSM mechanism to improve inter-channel information interaction while reducing the number of parameters. Extensive experiments have demonstrated that our method achieves state-of-the-art performance on five public datasets. Code is available at https://github.com/zs1314/Microscopic-Mamba